VAPA (VAMP associated protein A)

2014-08-01  

Identity

HGNC
LOCATION
18p11.22
LOCUSID
ALIAS
VAMP-A,VAP-33,VAP-A,VAP33,hVAP-33
FUSION GENES

Other Information

Locus ID:

NCBI: 9218
MIM: 605703
HGNC: 12648
Ensembl: ENSG00000101558

Variants:

dbSNP: 9218
ClinVar: 9218
TCGA: ENSG00000101558
COSMIC: VAPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101558ENST00000340541Q9P0L0
ENSG00000101558ENST00000400000Q9P0L0
ENSG00000101558ENST00000585042J3QKM9

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150168712004Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft.141
274198712016Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P.74
241052632013STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER.69
281085262017VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis.56
219571242012Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33.39
192894702009Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.29
187138372008FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation.23
254472042015OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.20
245699962014Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells.19
201789912010Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies.18

Citation

Dessen P

VAPA (VAMP associated protein A)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54766/vapa