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VAPA (VAMP associated protein A)

Identity

Alias_namesVAMP (vesicle-associated membrane protein)-associated protein A (33kD)
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
Alias_symbol (synonym)hVAP-33
VAP-A
Other aliasVAP-33
VAP33
HGNC (Hugo) VAPA
LocusID (NCBI) 9218
Atlas_Id 54766
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 9913958 and ends at 9960021 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HNRNPH1 (5q35.3) / VAPA (18p11.22)LOC100507412 (-) / VAPA (18p11.22)RAB31 (18p11.22) / VAPA (18p11.22)
TMEM38B (9q31.2) / VAPA (18p11.22)VAPA (18p11.22) / RAB31 (18p11.22)VAPA (18p11.22) / SEC11A (15q25.3)
VAPA (18p11.22) / VAPA (18p11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)VAPA   12648
Cards
Entrez_Gene (NCBI)VAPA  9218  VAMP associated protein A
AliasesVAP-33; VAP-A; VAP33; hVAP-33
GeneCards (Weizmann)VAPA
Ensembl hg19 (Hinxton)ENSG00000101558 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101558 [Gene_View]  chr18:9913958-9960021 [Contig_View]  VAPA [Vega]
ICGC DataPortalENSG00000101558
TCGA cBioPortalVAPA
AceView (NCBI)VAPA
Genatlas (Paris)VAPA
WikiGenes9218
SOURCE (Princeton)VAPA
Genetics Home Reference (NIH)VAPA
Genomic and cartography
GoldenPath hg38 (UCSC)VAPA  -     chr18:9913958-9960021 +  18p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VAPA  -     18p11.22   [Description]    (hg19-Feb_2009)
EnsemblVAPA - 18p11.22 [CytoView hg19]  VAPA - 18p11.22 [CytoView hg38]
Mapping of homologs : NCBIVAPA [Mapview hg19]  VAPA [Mapview hg38]
OMIM605703   
Gene and transcription
Genbank (Entrez)AF044670 AF057358 AF086627 AF154847 AK024299
RefSeq transcript (Entrez)NM_003574 NM_194434
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VAPA
Cluster EST : UnigeneHs.165195 [ NCBI ]
CGAP (NCI)Hs.165195
Alternative Splicing GalleryENSG00000101558
Gene ExpressionVAPA [ NCBI-GEO ]   VAPA [ EBI - ARRAY_EXPRESS ]   VAPA [ SEEK ]   VAPA [ MEM ]
Gene Expression Viewer (FireBrowse)VAPA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9218
GTEX Portal (Tissue expression)VAPA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P0L0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P0L0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P0L0
Splice isoforms : SwissVarQ9P0L0
PhosPhoSitePlusQ9P0L0
Domaine pattern : Prosite (Expaxy)MSP (PS50202)   
Domains : Interpro (EBI)MSP_dom    PapD-like    VAP    VAPA   
Domain families : Pfam (Sanger)Motile_Sperm (PF00635)   
Domain families : Pfam (NCBI)pfam00635   
Conserved Domain (NCBI)VAPA
DMDM Disease mutations9218
Blocks (Seattle)VAPA
PDB (SRS)2RR3   
PDB (PDBSum)2RR3   
PDB (IMB)2RR3   
PDB (RSDB)2RR3   
Structural Biology KnowledgeBase2RR3   
SCOP (Structural Classification of Proteins)2RR3   
CATH (Classification of proteins structures)2RR3   
SuperfamilyQ9P0L0
Human Protein AtlasENSG00000101558
Peptide AtlasQ9P0L0
HPRD09299
IPIIPI00170692   IPI00374657   
Protein Interaction databases
DIP (DOE-UCLA)Q9P0L0
IntAct (EBI)Q9P0L0
FunCoupENSG00000101558
BioGRIDVAPA
STRING (EMBL)VAPA
ZODIACVAPA
Ontologies - Pathways
QuickGOQ9P0L0
Ontology : AmiGOGolgi membrane  signal transducer activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  bicellular tight junction  ER to Golgi vesicle-mediated transport  endoplasmic reticulum organization  signal transduction  microtubule binding  cell death  microtubule cytoskeleton  integral component of membrane  protein domain specific binding  sphingolipid biosynthetic process  neuron projection development  nuclear membrane  vesicle  FFAT motif binding  protein folding in endoplasmic reticulum  azurophil granule membrane  positive regulation of I-kappaB kinase/NF-kappaB signaling  neutrophil degranulation  positive regulation by host of viral release from host cell  negative regulation by host of viral genome replication  positive regulation by host of viral genome replication  cadherin binding  protein heterodimerization activity  perinuclear region of cytoplasm  membrane fusion  endoplasmic reticulum exit site  protein localization to endoplasmic reticulum  COPII-coated vesicle budding  
Ontology : EGO-EBIGolgi membrane  signal transducer activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  bicellular tight junction  ER to Golgi vesicle-mediated transport  endoplasmic reticulum organization  signal transduction  microtubule binding  cell death  microtubule cytoskeleton  integral component of membrane  protein domain specific binding  sphingolipid biosynthetic process  neuron projection development  nuclear membrane  vesicle  FFAT motif binding  protein folding in endoplasmic reticulum  azurophil granule membrane  positive regulation of I-kappaB kinase/NF-kappaB signaling  neutrophil degranulation  positive regulation by host of viral release from host cell  negative regulation by host of viral genome replication  positive regulation by host of viral genome replication  cadherin binding  protein heterodimerization activity  perinuclear region of cytoplasm  membrane fusion  endoplasmic reticulum exit site  protein localization to endoplasmic reticulum  COPII-coated vesicle budding  
Pathways : KEGGTight junction   
NDEx NetworkVAPA
Atlas of Cancer Signalling NetworkVAPA
Wikipedia pathwaysVAPA
Orthology - Evolution
OrthoDB9218
GeneTree (enSembl)ENSG00000101558
Phylogenetic Trees/Animal Genes : TreeFamVAPA
HOVERGENQ9P0L0
HOGENOMQ9P0L0
Homologs : HomoloGeneVAPA
Homology/Alignments : Family Browser (UCSC)VAPA
Gene fusions - Rearrangements
Fusion : MitelmanHNRNPH1/VAPA [5q35.3/18p11.22]  [t(5;18)(q35;p11)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVAPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VAPA
dbVarVAPA
ClinVarVAPA
1000_GenomesVAPA 
Exome Variant ServerVAPA
ExAC (Exome Aggregation Consortium)VAPA (select the gene name)
Genetic variants : HAPMAP9218
Genomic Variants (DGV)VAPA [DGVbeta]
DECIPHERVAPA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVAPA 
Mutations
ICGC Data PortalVAPA 
TCGA Data PortalVAPA 
Broad Tumor PortalVAPA
OASIS PortalVAPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVAPA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVAPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VAPA
DgiDB (Drug Gene Interaction Database)VAPA
DoCM (Curated mutations)VAPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VAPA (select a term)
intoGenVAPA
Cancer3DVAPA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605703   
Orphanet
MedgenVAPA
Genetic Testing Registry VAPA
NextProtQ9P0L0 [Medical]
TSGene9218
GENETestsVAPA
Target ValidationVAPA
Huge Navigator VAPA [HugePedia]
snp3D : Map Gene to Disease9218
BioCentury BCIQVAPA
ClinGenVAPA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9218
Chemical/Pharm GKB GenePA37272
Clinical trialVAPA
Miscellaneous
canSAR (ICR)VAPA (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVAPA
EVEXVAPA
GoPubMedVAPA
iHOPVAPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:02:22 CEST 2017

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