Identity
HGNC
LOCATION
20q13.32
LOCUSID
ALIAS
ALS8,VAMP-B,VAP-B
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9217
MIM: 605704
HGNC: 12649
Ensembl: ENSG00000124164
Variants:
dbSNP: 9217
ClinVar: 9217
TCGA: ENSG00000124164
COSMIC: VAPB
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000124164 | ENST00000395802 | O95292 |
| ENSG00000124164 | ENST00000475243 | O95292 |
| ENSG00000124164 | ENST00000475243 | Q53XM7 |
| ENSG00000124164 | ENST00000520497 | E5RK64 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37381178 | 2024 | ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis. | 0 |
| 38267577 | 2024 | Motion of VAPB molecules reveals ER-mitochondria contact site subdomains. | 3 |
| 38395965 | 2024 | Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca(2+) and synaptic defects. | 1 |
| 38605278 | 2024 | Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis. | 1 |
| 37381178 | 2024 | ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis. | 0 |
| 38267577 | 2024 | Motion of VAPB molecules reveals ER-mitochondria contact site subdomains. | 3 |
| 38395965 | 2024 | Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca(2+) and synaptic defects. | 1 |
| 38605278 | 2024 | Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis. | 1 |
| 37509182 | 2023 | Yeast Models of Amyotrophic Lateral Sclerosis Type 8 Mimic Phenotypes Seen in Mammalian Cells Expressing Mutant VAPB(P56S). | 0 |
| 37945695 | 2023 | Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma. | 1 |
| 37509182 | 2023 | Yeast Models of Amyotrophic Lateral Sclerosis Type 8 Mimic Phenotypes Seen in Mammalian Cells Expressing Mutant VAPB(P56S). | 0 |
| 37945695 | 2023 | Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma. | 1 |
| 32818383 | 2022 | lncRNA DANCR Promotes Proliferation and Metastasis of Breast Cancer Cells Through Sponging miR-4319 and Upregulating VAPB. | 10 |
| 35019937 | 2022 | Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β. | 18 |
| 35950959 | 2022 | Alteration of Vesicle-Associated Membrane Protein-Binding Protein B in α-Synuclein Aggregates in Lewy Body Disease. | 0 |
Citation
Dessen P
VAPB (VAMP associated protein B and C)
Atlas Genet Cytogenet Oncol Haematol. 2013-03-01
Online version: http://atlasgeneticsoncology.org/gene/53207/vapb
