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VARS2 (valyl-tRNA synthetase 2, mitochondrial)

Identity

Other namesG7a
VARS2L
VARSL
HGNC (Hugo) VARS2
LocusID (NCBI) 57176
Location 6p21.33
Location_base_pair Starts at 30881982 and ends at 30894235 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)VARS2   21642
Entrez_Gene (NCBI)VARS2  57176  valyl-tRNA synthetase 2, mitochondrial
Cards
GeneCards (Weizmann)VARS2
Ensembl (Hinxton)ENSG00000137411 [Gene_View]  chr6:30881982-30894235 [Contig_View]  VARS2 [Vega]
AceView (NCBI)VARS2
Genatlas (Paris)VARS2
SOURCE (Stanford)NM_001167733 NM_001167734 NM_020442
Genomic and cartography
GoldenPath (UCSC)VARS2  -  6p21.33   chr6:30881982-30894235 +  6p21.33   [Description]    (hg19-Feb_2009)
EnsemblVARS2 - 6p21.33 [CytoView]
Mapping of homologs : NCBIVARS2 [Mapview]
OMIM612802   
Gene and transcription
Genbank (Entrez)AB067472 AK000511 AK025618 AK026063 AK094483
RefSeq transcript (SRS)NM_001167733 NM_001167734 NM_020442
RefSeq transcript (Entrez)NM_001167733 NM_001167734 NM_020442
RefSeq genomic (SRS)AC_000138 NC_000006 NC_018917 NT_007592 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NW_001838980 NW_004078026
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_007592 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NW_001838980 NW_004078026
Consensus coding sequences : CCDS (NCBI)VARS2
Cluster EST : UnigeneHs.597526 [ SRS ] Hs.597526 [ NCBI ]
CGAP (NCI)Hs.597526
Alternative Splicing : Fast-db (Paris)GSHG0033990
Alternative Splicing GalleryENSG00000137411
Gene ExpressionVARS2 [ NCBI-GEO ]   VARS2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5ST30 (SRS) Q5ST30 (Uniprot)
NextProtQ5ST30
With graphics : InterProQ5ST30
Splice isoforms : SwissVarQ5ST30(Swissvar)
Domaine pattern : Prosite (SRS)AA_TRNA_LIGASE_I (PS00178)   
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (SRS)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ia    Rossmann-like_a/b/a_fold    tRNAsynth_1a_anticodon-bd    V/L/I-tRNA-synth_anticodon-bd    Val/Leu/Ile-tRNA-synth_edit    Valyl-tRNA_ligase   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ia    Rossmann-like_a/b/a_fold    tRNAsynth_1a_anticodon-bd    V/L/I-tRNA-synth_anticodon-bd    Val/Leu/Ile-tRNA-synth_edit    Valyl-tRNA_ligase   
Related proteins : CluSTrQ5ST30
Domain families : Pfam (SRS)Anticodon_1 (PF08264)    tRNA-synt_1 (PF00133)   
Domain families : Pfam (Sanger)Anticodon_1 (PF08264)    tRNA-synt_1 (PF00133)   
Domain families : Pfam (NCBI)pfam08264    pfam00133   
DMDM57176
Blocks (Seattle)Q5ST30
Human Protein AtlasENSG00000137411
HPRD11670
IPIIPI00644468   IPI00895822   IPI00873561   IPI00640597   IPI00965955   IPI00792104   IPI00647631   
Protein Interaction databases
DIP (DOE-UCLA)Q5ST30
IntAct (EBI)Q5ST30
FunCoupENSG00000137411
REACTOMEVARS2
Protein Interaction Database57176
BioGRIDVARS2
InParanoidQ5ST30
Interologous Interaction database Q5ST30
IntegromeDBVARS2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)VARS2
SNP (GeneSNP Utah)VARS2
SNP : HGBaseVARS2
Genetic variants : HAPMAPVARS2
Somatic Mutations in Cancer : COSMICVARS2 
CONAN: Copy Number AnalysisVARS2 
Mutations and Diseases : HGMDVARS2
OMIM612802   
GENETests612802   
Disease Genetic AssociationVARS2
Huge Navigator VARS2 [HugePedia]  VARS2 [HugeCancerGEM]
Genomic VariantsVARS2  VARS2 [DGVbeta]
snp3D : Map Gene to Disease57176
General knowledge
Homologs : HomoloGeneVARS2
Homology/Alignments : Family Browser (UCSC)VARS2
Phylogenetic Trees/Animal Genes : TreeFamVARS2
Catalytic activity : Enzyme6.1.1.9 [ Enzyme-Expasy ]   6.1.1.9 [ Enzyme-SRS ]   6.1.1.9 [ IntEnz-EBI ]   6.1.1.9 [ BRENDA ]   6.1.1.9 [ KEGG ]   
Chemical/Protein Interactions : CTD57176
Chemical/Pharm GKB GenePA164742816
Clinical trialVARS2
Cancer Resource (Charite)ENSG00000137411
Ontology : AmiGOaminoacyl-tRNA editing activity  valine-tRNA ligase activity  ATP binding  mitochondrion  tRNA aminoacylation for protein translation  valyl-tRNA aminoacylation  gene expression  
Ontology : EGO-EBIaminoacyl-tRNA editing activity  valine-tRNA ligase activity  ATP binding  mitochondrion  tRNA aminoacylation for protein translation  valyl-tRNA aminoacylation  gene expression  
Other databases
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
PubGeneVARS2
iHOPVARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:32:20 CEST 2013
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