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VCL (vinculin)

Identity

Other aliasCMD1W
CMH15
HEL114
MV
MVCL
HGNC (Hugo) VCL
LocusID (NCBI) 7414
Atlas_Id 42785
Location 10q22.2  [Link to chromosome band 10q22]
Location_base_pair Starts at 73998114 and ends at 74120156 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C10orf11 (10q22.2) / VCL (10q22.2)KIF1C (17p13.2) / VCL (10q22.2)PPP1R10 (6p21.33) / VCL (10q22.2)
SLC44A2 (19p13.2) / VCL (10q22.2)VCL (10q22.2) / ABCC8 (11p15.1)VCL (10q22.2) / ADK (10q22.2)
VCL (10q22.2) / ALK (2p23.2)VCL (10q22.2) / FGFR2 (10q26.13)VCL (10q22.2) / NTRK2 (9q21.33)
VCL (10q22.2) / SEC24C (10q22.2)VCL (10q22.2) / SFTPD (10q22.3)VCL (10q22.2) / VCL (10q22.2)
VCL (10q22.2) / ZSWIM8 (10q22.2)VCL 10q22.2 / ALK 2p23.2C10orf11 10q22.2 / VCL 10q22.2
VCL 10q22.2 / FGFR2 10q26.13VCL 10q22.2 KIAA0913VCL 10q22.2 / SEC24C 10q22.2
VCL 10q22.2 / SFTPD 10q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]

Solid Tumors ALKrenalCellCarcID6279 TT_t0910q21q22ID108268 TT_t1010q22q22ID100218 TT_t1010q22q22ID100219 TT_t1010q22q22ID100220
TT_t1010q22q26ID100227 TT_t1011q22p15ID100321

External links

Nomenclature
HGNC (Hugo)VCL   12665
LRG (Locus Reference Genomic)LRG_383
Cards
Entrez_Gene (NCBI)VCL  7414  vinculin
AliasesCMD1W; CMH15; HEL114; MV; 
MVCL
GeneCards (Weizmann)VCL
Ensembl hg19 (Hinxton)ENSG00000035403 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000035403 [Gene_View]  ENSG00000035403 [Sequence]  chr10:73998114-74120156 [Contig_View]  VCL [Vega]
ICGC DataPortalENSG00000035403
TCGA cBioPortalVCL
AceView (NCBI)VCL
Genatlas (Paris)VCL
WikiGenes7414
SOURCE (Princeton)VCL
Genetics Home Reference (NIH)VCL
Genomic and cartography
GoldenPath hg38 (UCSC)VCL  -     chr10:73998114-74120156 +  10q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VCL  -     10q22.2   [Description]    (hg19-Feb_2009)
GoldenPathVCL - 10q22.2 [CytoView hg19]  VCL - 10q22.2 [CytoView hg38]
ImmunoBaseENSG00000035403
Mapping of homologs : NCBIVCL [Mapview hg19]  VCL [Mapview hg38]
OMIM193065   611407   613255   
Gene and transcription
Genbank (Entrez)AA368699 AI290052 AK126978 AK296509 AK300280
RefSeq transcript (Entrez)NM_003373 NM_014000
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VCL
Alternative Splicing GalleryENSG00000035403
Gene ExpressionVCL [ NCBI-GEO ]   VCL [ EBI - ARRAY_EXPRESS ]   VCL [ SEEK ]   VCL [ MEM ]
Gene Expression Viewer (FireBrowse)VCL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)7414
GTEX Portal (Tissue expression)VCL
Human Protein AtlasENSG00000035403-VCL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)VCL
DMDM Disease mutations7414
Blocks (Seattle)VCL
Human Protein Atlas [tissue]ENSG00000035403-VCL [tissue]
HPRD01900
IPIIPI00307162   IPI00291175   IPI00384973   IPI00909711   IPI01011952   IPI00910496   IPI01014113   
Protein Interaction databases
FunCoupENSG00000035403
BioGRIDVCL
STRING (EMBL)VCL
ZODIACVCL
Ontologies - Pathways
Huge Navigator VCL [HugePedia]
snp3D : Map Gene to Disease7414
BioCentury BCIQVCL
ClinGenVCL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7414
Chemical/Pharm GKB GenePA37288
Clinical trialVCL
Miscellaneous
canSAR (ICR)VCL (select the gene name)
DataMed IndexVCL
Probes
Litterature
PubMed214 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVCL
EVEXVCL
GoPubMedVCL
iHOPVCL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 19 17:16:09 CET 2020
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