VEGFA (vascular endothelial growth factor A)

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VEGFA (vascular endothelial growth factor A)

Identity

Other names	MVCD1
	VEGF
	VPF
HGNC (Hugo)	VEGFA
LocusID (NCBI)	7422
Location	6p21.1
Location_base_pair	Starts at 43737946 and ends at 43754223 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	VEGFA 12680
Entrez_Gene (NCBI)	VEGFA 7422 vascular endothelial growth factor A
	Cards
GeneCards (Weizmann)	VEGFA
Ensembl (Hinxton)	ENSG00000112715 [Gene_View] chr6:43737946-43754223 [Contig_View] VEGFA [Vega]
AceView (NCBI)	VEGFA
Genatlas (Paris)	VEGFA
SOURCE (Stanford)	NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_001204384 NM_001204385 NM_003376
	Genomic and cartography
GoldenPath (UCSC)	VEGFA - 6p21.1 chr6:43737946-43754223 + 6p21.1 [Description] (hg19-Feb_2009)
Ensembl	VEGFA - 6p21.1 [CytoView]
Mapping of homologs : NCBI	VEGFA [Mapview]
OMIM	125853 192240 603933
	Gene and transcription
Genbank (Entrez)	AB021221 AB209485 AB451322 AB451451 AF022375
RefSeq transcript (SRS)	NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_001204384 NM_001204385 NM_003376
RefSeq transcript (Entrez)	NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_001204384 NM_001204385 NM_003376
RefSeq genomic (SRS)	AC_000138 NC_000006 NC_018917 NG_008732 NT_007592 NW_001838981 NW_004078026
RefSeq genomic (Entrez)	AC_000138 NC_000006 NC_018917 NG_008732 NT_007592 NW_001838981 NW_004078026
Consensus coding sequences : CCDS (NCBI)	VEGFA
Cluster EST : Unigene	Hs.73793 [ SRS ] Hs.73793 [ NCBI ]
CGAP (NCI)	Hs.73793
Alternative Splicing : Fast-db (Paris)	GSHG0025760
Alternative Splicing Gallery	ENSG00000112715
Gene Expression	VEGFA [ NCBI-GEO ] VEGFA [ EBI - ARRAY_EXPRESS ]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P15692 (SRS) P15692 (Uniprot)
NextProt	P15692
With graphics : InterPro	P15692
Splice isoforms : SwissVar	P15692(Swissvar)
Domaine pattern : Prosite (SRS)	PDGF_1 (PS00249) PDGF_2 (PS50278)
Domaine pattern : Prosite (Expaxy)	PDGF_1 (PS00249) PDGF_2 (PS50278)
Domains : Interpro (SRS)	PD_growth_factor PD_growth_factor_CS
Domains : Interpro (EBI)	PD_growth_factor PD_growth_factor_CS
Related proteins : CluSTr	P15692
Domain families : Pfam (SRS)	PDGF (PF00341)
Domain families : Pfam (Sanger)	PDGF (PF00341)
Domain families : Pfam (NCBI)	pfam00341
Domain families : Smart (EMBL)	PDGF (SM00141)
DMDM	7422
Blocks (Seattle)	P15692
PDB (SRS)	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS
PDB (PDBSum)	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS
PDB (IMB)	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS
PDB (RSDB)	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS
Human Protein Atlas	ENSG00000112715
HPRD	01889
IPI	IPI00954880 IPI00954917 IPI00374772 IPI00852889 IPI00216553 IPI00012567 IPI00940477 IPI00954971 IPI00829762 IPI00954943 IPI00216555 IPI00955048 IPI00607893 IPI00555908 IPI00436015 IPI01017982 IPI00216554 IPI00064652 IPI00607783 IPI00954902 IPI00984701 IPI00976032 IPI00982395
	Protein Interaction databases
DIP (DOE-UCLA)	P15692
IntAct (EBI)	P15692
FunCoup	ENSG00000112715
REACTOME	VEGFA
Protein Interaction Database	7422
BioGRID	VEGFA
InParanoid	P15692
Interologous Interaction database	P15692
IntegromeDB	VEGFA
	Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)	VEGFA
SNP (GeneSNP Utah)	VEGFA
SNP : HGBase	VEGFA
Genetic variants : HAPMAP	VEGFA
Somatic Mutations in Cancer : COSMIC	VEGFA
CONAN: Copy Number Analysis	VEGFA
Mutations and Diseases : HGMD	VEGFA
OMIM	125853 192240 603933
GENETests	125853 192240 603933
Disease Genetic Association	VEGFA
Huge Navigator	VEGFA [HugePedia] VEGFA [HugeCancerGEM]
Genomic Variants	VEGFA VEGFA [DGVbeta]
snp3D : Map Gene to Disease	7422
	General knowledge
Homologs : HomoloGene	VEGFA
Homology/Alignments : Family Browser (UCSC)	VEGFA
Phylogenetic Trees/Animal Genes : TreeFam	VEGFA
Chemical/Protein Interactions : CTD	7422
Chemical/Pharm GKB Gene	PA37302
Clinical trial	VEGFA
Cancer Resource (Charite)	ENSG00000112715
Ontology : AmiGO	negative regulation of transcription from RNA polymerase II promoter angiogenesis ovarian follicle development patterning of blood vessels vasculogenesis response to hypoxia in utero embryonic development kidney development positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation fibronectin binding blood vessel remodeling cell migration involved in sprouting angiogenesis positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation positive regulation of receptor internalization basophil chemotaxis platelet degranulation positive regulation of leukocyte migration heart morphogenesis outflow tract morphogenesis coronary vein morphogenesis cytokine activity cytokine activity platelet-derived growth factor receptor binding vascular endothelial growth factor receptor binding protein binding extracellular region proteinaceous extracellular matrix basement membrane extracellular space extracellular space cytoplasm regulation of transcription from RNA polymerase II promoter nervous system development mesoderm development lactation blood coagulation behavior growth factor activity growth factor activity heparin binding heparin binding cell proliferation positive regulation of cell proliferation regulation of cell shape response to cold cell surface positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of intracellular protein kinase cascade membrane secretory granule platelet activation monocyte differentiation macrophage differentiation lung development positive regulation of cell migration epithelial cell differentiation positive regulation of vascular endothelial growth factor receptor signaling pathway post-embryonic camera-type eye development platelet alpha granule lumen positive regulation of protein complex assembly positive regulation of protein autophosphorylation activation of protein kinase activity positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation cellular response to stress endothelial cell chemotaxis cellular response to vascular endothelial growth factor stimulus lymph vessel morphogenesis positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway growth chemoattractant activity T-helper 1 type immune response eye photoreceptor cell development identical protein binding protein homodimerization activity negative regulation of apoptotic process positive regulation of vascular permeability positive regulation of vascular permeability surfactant homeostasis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process vascular endothelial growth factor receptor 1 binding vascular endothelial growth factor receptor 2 binding positive regulation of MAP kinase activity cell surface binding positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of angiogenesis negative regulation of bone resorption positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity vascular endothelial growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway receptor agonist activity mRNA stabilization lung alveolus development cell maturation camera-type eye morphogenesis positive regulation of smooth muscle cell proliferation cardiac muscle fiber development branching morphogenesis of a tube artery morphogenesis positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation extracellular matrix binding positive chemotaxis positive regulation of positive chemotaxis induction of positive chemotaxis induction of positive chemotaxis positive regulation of cellular component movement positive regulation of cell division positive regulation of focal adhesion assembly primitive erythrocyte differentiation mammary gland alveolus development positive regulation of mast cell chemotaxis cardiac vascular smooth muscle cell development coronary artery morphogenesis regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to hypoxia cellular response to hypoxia dopaminergic neuron differentiation positive regulation of protein kinase C signaling cascade positive regulation of cell migration involved in sprouting angiogenesis positive regulation of branching involved in ureteric bud morphogenesis positive regulation of peptidyl-tyrosine autophosphorylation positive regulation of p38MAPK cascade positive regulation of histone deacetylase activity
Ontology : EGO-EBI	negative regulation of transcription from RNA polymerase II promoter angiogenesis ovarian follicle development patterning of blood vessels vasculogenesis response to hypoxia in utero embryonic development kidney development positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation fibronectin binding blood vessel remodeling cell migration involved in sprouting angiogenesis positive regulation of neuroblast proliferation positive regulation of mesenchymal cell proliferation positive regulation of receptor internalization basophil chemotaxis platelet degranulation positive regulation of leukocyte migration heart morphogenesis outflow tract morphogenesis coronary vein morphogenesis cytokine activity cytokine activity platelet-derived growth factor receptor binding vascular endothelial growth factor receptor binding protein binding extracellular region proteinaceous extracellular matrix basement membrane extracellular space extracellular space cytoplasm regulation of transcription from RNA polymerase II promoter nervous system development mesoderm development lactation blood coagulation behavior growth factor activity growth factor activity heparin binding heparin binding cell proliferation positive regulation of cell proliferation regulation of cell shape response to cold cell surface positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of intracellular protein kinase cascade membrane secretory granule platelet activation monocyte differentiation macrophage differentiation lung development positive regulation of cell migration epithelial cell differentiation positive regulation of vascular endothelial growth factor receptor signaling pathway post-embryonic camera-type eye development platelet alpha granule lumen positive regulation of protein complex assembly positive regulation of protein autophosphorylation activation of protein kinase activity positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation cellular response to stress endothelial cell chemotaxis cellular response to vascular endothelial growth factor stimulus lymph vessel morphogenesis positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway growth chemoattractant activity T-helper 1 type immune response eye photoreceptor cell development identical protein binding protein homodimerization activity negative regulation of apoptotic process positive regulation of vascular permeability positive regulation of vascular permeability surfactant homeostasis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process vascular endothelial growth factor receptor 1 binding vascular endothelial growth factor receptor 2 binding positive regulation of MAP kinase activity cell surface binding positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis positive regulation of angiogenesis negative regulation of bone resorption positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter protein heterodimerization activity vascular endothelial growth factor receptor signaling pathway vascular endothelial growth factor receptor signaling pathway receptor agonist activity mRNA stabilization lung alveolus development cell maturation camera-type eye morphogenesis positive regulation of smooth muscle cell proliferation cardiac muscle fiber development branching morphogenesis of a tube artery morphogenesis positive regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation extracellular matrix binding positive chemotaxis positive regulation of positive chemotaxis induction of positive chemotaxis induction of positive chemotaxis positive regulation of cellular component movement positive regulation of cell division positive regulation of focal adhesion assembly primitive erythrocyte differentiation mammary gland alveolus development positive regulation of mast cell chemotaxis cardiac vascular smooth muscle cell development coronary artery morphogenesis regulation of transcription from RNA polymerase II promoter in response to hypoxia positive regulation of transcription from RNA polymerase II promoter in response to hypoxia cellular response to hypoxia cellular response to hypoxia dopaminergic neuron differentiation positive regulation of protein kinase C signaling cascade positive regulation of cell migration involved in sprouting angiogenesis positive regulation of branching involved in ureteric bud morphogenesis positive regulation of peptidyl-tyrosine autophosphorylation positive regulation of p38MAPK cascade positive regulation of histone deacetylase activity
Pathways : BIOCARTA	VEGF, Hypoxia, and Angiogenesis [Genes] Hypoxia-Inducible Factor in the Cardiovascular System [Genes] Actions of Nitric Oxide in the Heart [Genes]
Pathways : KEGG	Cytokine-cytokine receptor interaction Focal adhesion VEGF signaling pathway mTOR signaling pathway
	Other databases
	Probes
	Litterature
PubMed	499 Pubmed reference(s) in Entrez
PubGene	VEGFA
iHOP	VEGFA

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	01-2013	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:19:30 CEST 2013

Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Case Reports Journals Portal Teaching

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jlhuret@AtlasGeneticsOncology.org.

Atlas of Genetics and Cytogenetics in Oncology and Haematology

VEGFA (vascular endothelial growth factor A)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute