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VEGFA (vascular endothelial growth factor A)

Identity

Alias_namesVEGF
vascular endothelial growth factor
Alias_symbol (synonym)VEGF-A
VPF
Other aliasMVCD1
HGNC (Hugo) VEGFA
LocusID (NCBI) 7422
Atlas_Id 42787
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 43770209 and ends at 43786486 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
VEGFA (6p21.1) / DDX27 (20q13.13)VEGFA (6p21.1) / KIF6 (6p21.2)VEGFA (6p21.1) / SUZ12P1 (17q11.2)
VEGFA (6p21.1) / TRBV20-1 ()VEGFA (6p21.1) / VEGFA (6p21.1)VEGFA 6p21.1 / DDX27 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Multiple Myeloma
t(1;9)(p13;p12) PAX5/HIPK1
t(14;16)(q32;q23) IGH/MAF


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 9 ]
  Thyroid: Anaplastic (undifferentiated) carcinoma
Neuro-Endocrine/Endocrine system: Carcinoid tumors
Colon: Colorectal adenocarcinoma
Head and Neck: Ear: Endolymphatic Sac Tumor (ELST)
Eye tumors: an overview
Thyroid: Medullary carcinoma
Head and neck: Retinoblastoma
Head and Neck: Thymus: Thymoma: an overview
t(6;20)(p21;q13) VEGFA/DDX27


External links

Nomenclature
HGNC (Hugo)VEGFA   12680
Cards
Entrez_Gene (NCBI)VEGFA  7422  vascular endothelial growth factor A
AliasesMVCD1; VEGF; VPF
GeneCards (Weizmann)VEGFA
Ensembl hg19 (Hinxton)ENSG00000112715 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112715 [Gene_View]  ENSG00000112715 [Sequence]  chr6:43770209-43786486 [Contig_View]  VEGFA [Vega]
ICGC DataPortalENSG00000112715
TCGA cBioPortalVEGFA
AceView (NCBI)VEGFA
Genatlas (Paris)VEGFA
WikiGenes7422
SOURCE (Princeton)VEGFA
Genetics Home Reference (NIH)VEGFA
Genomic and cartography
GoldenPath hg38 (UCSC)VEGFA  -     chr6:43770209-43786486 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VEGFA  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblVEGFA - 6p21.1 [CytoView hg19]  VEGFA - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIVEGFA [Mapview hg19]  VEGFA [Mapview hg38]
OMIM192240   603933   
Gene and transcription
Genbank (Entrez)AB021221 AB209485 AB451322 AB451451 AF022375
RefSeq transcript (Entrez)NM_001025366 NM_001025367 NM_001025368 NM_001025369 NM_001025370 NM_001033756 NM_001171622 NM_001171623 NM_001171624 NM_001171625 NM_001171626 NM_001171627 NM_001171628 NM_001171629 NM_001171630 NM_001204384 NM_001204385 NM_001287044 NM_001317010 NM_003376
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VEGFA
Cluster EST : UnigeneHs.73793 [ NCBI ]
CGAP (NCI)Hs.73793
Alternative Splicing GalleryENSG00000112715
Gene ExpressionVEGFA [ NCBI-GEO ]   VEGFA [ EBI - ARRAY_EXPRESS ]   VEGFA [ SEEK ]   VEGFA [ MEM ]
Gene Expression Viewer (FireBrowse)VEGFA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7422
GTEX Portal (Tissue expression)VEGFA
Human Protein AtlasENSG00000112715-VEGFA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15692   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15692  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15692
Splice isoforms : SwissVarP15692
PhosPhoSitePlusP15692
Domaine pattern : Prosite (Expaxy)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domains : Interpro (EBI)Cystine-knot_cytokine    PD_growth_factor_CS    PDGF/VEGF_dom    VEGF_C    VEGF_C_sf   
Domain families : Pfam (Sanger)PDGF (PF00341)    VEGF_C (PF14554)   
Domain families : Pfam (NCBI)pfam00341    pfam14554   
Domain families : Smart (EMBL)PDGF (SM00141)  
Conserved Domain (NCBI)VEGFA
DMDM Disease mutations7422
Blocks (Seattle)VEGFA
PDB (SRS)1BJ1    1CZ8    1FLT    1KAT    1KMX    1MJV    1MKG    1MKK    1QTY    1TZH    1TZI    1VGH    1VPF    1VPP    2FJG    2FJH    2QR0    2VGH    2VPF    3BDY    3P9W    3QTK    3S1B    3S1K    3V2A    4DEQ    4GLN    4GLS    4KZN    4QAF    4WPB    4ZFF    5DN2    5FV1    5FV2    5HHC    5HHD    5O4E    5T89   
PDB (PDBSum)1BJ1    1CZ8    1FLT    1KAT    1KMX    1MJV    1MKG    1MKK    1QTY    1TZH    1TZI    1VGH    1VPF    1VPP    2FJG    2FJH    2QR0    2VGH    2VPF    3BDY    3P9W    3QTK    3S1B    3S1K    3V2A    4DEQ    4GLN    4GLS    4KZN    4QAF    4WPB    4ZFF    5DN2    5FV1    5FV2    5HHC    5HHD    5O4E    5T89   
PDB (IMB)1BJ1    1CZ8    1FLT    1KAT    1KMX    1MJV    1MKG    1MKK    1QTY    1TZH    1TZI    1VGH    1VPF    1VPP    2FJG    2FJH    2QR0    2VGH    2VPF    3BDY    3P9W    3QTK    3S1B    3S1K    3V2A    4DEQ    4GLN    4GLS    4KZN    4QAF    4WPB    4ZFF    5DN2    5FV1    5FV2    5HHC    5HHD    5O4E    5T89   
PDB (RSDB)1BJ1    1CZ8    1FLT    1KAT    1KMX    1MJV    1MKG    1MKK    1QTY    1TZH    1TZI    1VGH    1VPF    1VPP    2FJG    2FJH    2QR0    2VGH    2VPF    3BDY    3P9W    3QTK    3S1B    3S1K    3V2A    4DEQ    4GLN    4GLS    4KZN    4QAF    4WPB    4ZFF    5DN2    5FV1    5FV2    5HHC    5HHD    5O4E    5T89   
Structural Biology KnowledgeBase1BJ1    1CZ8    1FLT    1KAT    1KMX    1MJV    1MKG    1MKK    1QTY    1TZH    1TZI    1VGH    1VPF    1VPP    2FJG    2FJH    2QR0    2VGH    2VPF    3BDY    3P9W    3QTK    3S1B    3S1K    3V2A    4DEQ    4GLN    4GLS    4KZN    4QAF    4WPB    4ZFF    5DN2    5FV1    5FV2    5HHC    5HHD    5O4E    5T89   
SCOP (Structural Classification of Proteins)1BJ1    1CZ8    1FLT    1KAT    1KMX    1MJV    1MKG    1MKK    1QTY    1TZH    1TZI    1VGH    1VPF    1VPP    2FJG    2FJH    2QR0    2VGH    2VPF    3BDY    3P9W    3QTK    3S1B    3S1K    3V2A    4DEQ    4GLN    4GLS    4KZN    4QAF    4WPB    4ZFF    5DN2    5FV1    5FV2    5HHC    5HHD    5O4E    5T89   
CATH (Classification of proteins structures)1BJ1    1CZ8    1FLT    1KAT    1KMX    1MJV    1MKG    1MKK    1QTY    1TZH    1TZI    1VGH    1VPF    1VPP    2FJG    2FJH    2QR0    2VGH    2VPF    3BDY    3P9W    3QTK    3S1B    3S1K    3V2A    4DEQ    4GLN    4GLS    4KZN    4QAF    4WPB    4ZFF    5DN2    5FV1    5FV2    5HHC    5HHD    5O4E    5T89   
SuperfamilyP15692
Human Protein Atlas [tissue]ENSG00000112715-VEGFA [tissue]
Peptide AtlasP15692
HPRD01889
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)P15692
IntAct (EBI)P15692
FunCoupENSG00000112715
BioGRIDVEGFA
STRING (EMBL)VEGFA
ZODIACVEGFA
Ontologies - Pathways
QuickGOP15692
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  angiogenesis  angiogenesis  ovarian follicle development  branching involved in blood vessel morphogenesis  vasculogenesis  response to hypoxia  response to hypoxia  in utero embryonic development  kidney development  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  fibronectin binding  sprouting angiogenesis  cell migration involved in sprouting angiogenesis  positive regulation of neuroblast proliferation  positive regulation of mesenchymal cell proliferation  positive regulation of receptor internalization  platelet degranulation  positive regulation of leukocyte migration  heart morphogenesis  outflow tract morphogenesis  coronary vein morphogenesis  cytokine activity  cytokine activity  platelet-derived growth factor receptor binding  vascular endothelial growth factor receptor binding  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  cytoplasm  regulation of transcription by RNA polymerase II  nervous system development  mesoderm development  lactation  growth factor activity  growth factor activity  growth factor activity  heparin binding  heparin binding  positive regulation of cell proliferation  positive regulation of cell proliferation  regulation of cell shape  cell surface  regulation of signaling receptor activity  positive regulation of endothelial cell migration  positive regulation of gene expression  negative regulation of gene expression  membrane  cytokine-mediated signaling pathway  secretory granule  monocyte differentiation  macrophage differentiation  lung development  positive regulation of cell migration  epithelial cell differentiation  positive regulation of vascular endothelial growth factor receptor signaling pathway  extracellular matrix  post-embryonic camera-type eye development  platelet alpha granule lumen  positive regulation of protein complex assembly  positive regulation of protein autophosphorylation  activation of protein kinase activity  positive regulation of CREB transcription factor activity  positive regulation of peptidyl-serine phosphorylation  tube formation  endothelial cell chemotaxis  cellular response to vascular endothelial growth factor stimulus  lymph vessel morphogenesis  positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor signaling pathway  positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  VEGF-activated neuropilin signaling pathway  chemoattractant activity  chemoattractant activity  eye photoreceptor cell development  positive regulation of tyrosine phosphorylation of STAT protein  identical protein binding  protein homodimerization activity  negative regulation of apoptotic process  surfactant homeostasis  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  vascular endothelial growth factor receptor 1 binding  vascular endothelial growth factor receptor 1 binding  vascular endothelial growth factor receptor 2 binding  vascular endothelial growth factor receptor 2 binding  vascular endothelial growth factor receptor 3 binding  positive regulation of MAP kinase activity  positive regulation of blood vessel endothelial cell migration  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of cell adhesion  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  receptor ligand activity  cell maturation  camera-type eye morphogenesis  cardiac muscle fiber development  branching morphogenesis of an epithelial tube  positive regulation of axon extension involved in axon guidance  artery morphogenesis  positive regulation of epithelial cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  extracellular matrix binding  positive chemotaxis  positive regulation of positive chemotaxis  induction of positive chemotaxis  induction of positive chemotaxis  positive regulation of cellular component movement  positive regulation of cell division  positive regulation of focal adhesion assembly  primitive erythrocyte differentiation  mammary gland alveolus development  positive regulation of mast cell chemotaxis  cardiac vascular smooth muscle cell development  coronary artery morphogenesis  regulation of transcription from RNA polymerase II promoter in response to hypoxia  positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  cellular response to hypoxia  dopaminergic neuron differentiation  commissural neuron axon guidance  positive regulation of protein kinase C signaling  positive regulation of cell migration involved in sprouting angiogenesis  positive regulation of cell migration involved in sprouting angiogenesis  positive regulation of cell migration involved in sprouting angiogenesis  positive regulation of branching involved in ureteric bud morphogenesis  regulation of retinal ganglion cell axon guidance  motor neuron migration  cellular stress response to acid chemical  positive regulation of peptidyl-tyrosine autophosphorylation  positive regulation of p38MAPK cascade  positive regulation of histone deacetylase activity  positive regulation of retinal ganglion cell axon guidance  positive regulation of protein kinase D signaling  positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  positive regulation of sprouting angiogenesis  positive regulation of sprouting angiogenesis  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  angiogenesis  angiogenesis  ovarian follicle development  branching involved in blood vessel morphogenesis  vasculogenesis  response to hypoxia  response to hypoxia  in utero embryonic development  kidney development  positive regulation of protein phosphorylation  positive regulation of protein phosphorylation  positive regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  fibronectin binding  sprouting angiogenesis  cell migration involved in sprouting angiogenesis  positive regulation of neuroblast proliferation  positive regulation of mesenchymal cell proliferation  positive regulation of receptor internalization  platelet degranulation  positive regulation of leukocyte migration  heart morphogenesis  outflow tract morphogenesis  coronary vein morphogenesis  cytokine activity  cytokine activity  platelet-derived growth factor receptor binding  vascular endothelial growth factor receptor binding  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  cytoplasm  regulation of transcription by RNA polymerase II  nervous system development  mesoderm development  lactation  growth factor activity  growth factor activity  growth factor activity  heparin binding  heparin binding  positive regulation of cell proliferation  positive regulation of cell proliferation  regulation of cell shape  cell surface  regulation of signaling receptor activity  positive regulation of endothelial cell migration  positive regulation of gene expression  negative regulation of gene expression  membrane  cytokine-mediated signaling pathway  secretory granule  monocyte differentiation  macrophage differentiation  lung development  positive regulation of cell migration  epithelial cell differentiation  positive regulation of vascular endothelial growth factor receptor signaling pathway  extracellular matrix  post-embryonic camera-type eye development  platelet alpha granule lumen  positive regulation of protein complex assembly  positive regulation of protein autophosphorylation  activation of protein kinase activity  positive regulation of CREB transcription factor activity  positive regulation of peptidyl-serine phosphorylation  tube formation  endothelial cell chemotaxis  cellular response to vascular endothelial growth factor stimulus  lymph vessel morphogenesis  positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor signaling pathway  positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway  VEGF-activated neuropilin signaling pathway  chemoattractant activity  chemoattractant activity  eye photoreceptor cell development  positive regulation of tyrosine phosphorylation of STAT protein  identical protein binding  protein homodimerization activity  negative regulation of apoptotic process  surfactant homeostasis  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  vascular endothelial growth factor receptor 1 binding  vascular endothelial growth factor receptor 1 binding  vascular endothelial growth factor receptor 2 binding  vascular endothelial growth factor receptor 2 binding  vascular endothelial growth factor receptor 3 binding  positive regulation of MAP kinase activity  positive regulation of blood vessel endothelial cell migration  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of cell adhesion  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  vascular endothelial growth factor receptor signaling pathway  receptor ligand activity  cell maturation  camera-type eye morphogenesis  cardiac muscle fiber development  branching morphogenesis of an epithelial tube  positive regulation of axon extension involved in axon guidance  artery morphogenesis  positive regulation of epithelial cell proliferation  positive regulation of peptidyl-tyrosine phosphorylation  extracellular matrix binding  positive chemotaxis  positive regulation of positive chemotaxis  induction of positive chemotaxis  induction of positive chemotaxis  positive regulation of cellular component movement  positive regulation of cell division  positive regulation of focal adhesion assembly  primitive erythrocyte differentiation  mammary gland alveolus development  positive regulation of mast cell chemotaxis  cardiac vascular smooth muscle cell development  coronary artery morphogenesis  regulation of transcription from RNA polymerase II promoter in response to hypoxia  positive regulation of transcription from RNA polymerase II promoter in response to hypoxia  cellular response to hypoxia  dopaminergic neuron differentiation  commissural neuron axon guidance  positive regulation of protein kinase C signaling  positive regulation of cell migration involved in sprouting angiogenesis  positive regulation of cell migration involved in sprouting angiogenesis  positive regulation of cell migration involved in sprouting angiogenesis  positive regulation of branching involved in ureteric bud morphogenesis  regulation of retinal ganglion cell axon guidance  motor neuron migration  cellular stress response to acid chemical  positive regulation of peptidyl-tyrosine autophosphorylation  positive regulation of p38MAPK cascade  positive regulation of histone deacetylase activity  positive regulation of retinal ganglion cell axon guidance  positive regulation of protein kinase D signaling  positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  positive regulation of sprouting angiogenesis  positive regulation of sprouting angiogenesis  
Pathways : KEGG   
NDEx NetworkVEGFA
Atlas of Cancer Signalling NetworkVEGFA
Wikipedia pathwaysVEGFA
Orthology - Evolution
OrthoDB7422
GeneTree (enSembl)ENSG00000112715
Phylogenetic Trees/Animal Genes : TreeFamVEGFA
HOVERGENP15692
HOGENOMP15692
Homologs : HomoloGeneVEGFA
Homology/Alignments : Family Browser (UCSC)VEGFA
Gene fusions - Rearrangements
Fusion : MitelmanVEGFA/DDX27 [6p21.1/20q13.13]  
Fusion PortalVEGFA 6p21.1 DDX27 20q13.13 KIRC
Fusion : QuiverVEGFA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVEGFA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VEGFA
dbVarVEGFA
ClinVarVEGFA
1000_GenomesVEGFA 
Exome Variant ServerVEGFA
ExAC (Exome Aggregation Consortium)ENSG00000112715
GNOMAD BrowserENSG00000112715
Varsome BrowserVEGFA
Genetic variants : HAPMAP7422
Genomic Variants (DGV)VEGFA [DGVbeta]
DECIPHERVEGFA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVEGFA 
Mutations
ICGC Data PortalVEGFA 
TCGA Data PortalVEGFA 
Broad Tumor PortalVEGFA
OASIS PortalVEGFA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVEGFA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVEGFA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VEGFA
DgiDB (Drug Gene Interaction Database)VEGFA
DoCM (Curated mutations)VEGFA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VEGFA (select a term)
intoGenVEGFA
Cancer3DVEGFA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM192240    603933   
Orphanet
DisGeNETVEGFA
MedgenVEGFA
Genetic Testing Registry VEGFA
NextProtP15692 [Medical]
TSGene7422
GENETestsVEGFA
Target ValidationVEGFA
Huge Navigator VEGFA [HugePedia]
snp3D : Map Gene to Disease7422
BioCentury BCIQVEGFA
ClinGenVEGFA (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7422
Chemical/Pharm GKB GenePA37302
Clinical trialVEGFA
Miscellaneous
canSAR (ICR)VEGFA (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVEGFA
EVEXVEGFA
GoPubMedVEGFA
iHOPVEGFA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 12:01:19 CEST 2018

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