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VEGFB (vascular endothelial growth factor B)

Identity

Alias_namesVRF
Alias_symbol (synonym)VEGFL
Other alias
HGNC (Hugo) VEGFB
LocusID (NCBI) 7423
Atlas_Id 42788
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64002056 and ends at 64006736 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PLCB3 (11q13.1) / VEGFB (11q13.1)VEGFB (11q13.1) / VEGFB (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)VEGFB   12681
Cards
Entrez_Gene (NCBI)VEGFB  7423  vascular endothelial growth factor B
AliasesVEGFL; VRF
GeneCards (Weizmann)VEGFB
Ensembl hg19 (Hinxton)ENSG00000173511 [Gene_View]  chr11:64002056-64006736 [Contig_View]  VEGFB [Vega]
Ensembl hg38 (Hinxton)ENSG00000173511 [Gene_View]  chr11:64002056-64006736 [Contig_View]  VEGFB [Vega]
ICGC DataPortalENSG00000173511
TCGA cBioPortalVEGFB
AceView (NCBI)VEGFB
Genatlas (Paris)VEGFB
WikiGenes7423
SOURCE (Princeton)VEGFB
Genetics Home Reference (NIH)VEGFB
Genomic and cartography
GoldenPath hg19 (UCSC)VEGFB  -     chr11:64002056-64006736 +  11q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)VEGFB  -     11q13.1   [Description]    (hg38-Dec_2013)
EnsemblVEGFB - 11q13.1 [CytoView hg19]  VEGFB - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIVEGFB [Mapview hg19]  VEGFB [Mapview hg38]
OMIM601398   
Gene and transcription
Genbank (Entrez)BC008818 BG031449 BM694361 BU730521 DQ892633
RefSeq transcript (Entrez)NM_001243733 NM_003377
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_029823 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)VEGFB
Cluster EST : UnigeneHs.732095 [ NCBI ]
CGAP (NCI)Hs.732095
Alternative Splicing GalleryENSG00000173511
Gene ExpressionVEGFB [ NCBI-GEO ]   VEGFB [ EBI - ARRAY_EXPRESS ]   VEGFB [ SEEK ]   VEGFB [ MEM ]
Gene Expression Viewer (FireBrowse)VEGFB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7423
GTEX Portal (Tissue expression)VEGFB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49765   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49765  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49765
Splice isoforms : SwissVarP49765
PhosPhoSitePlusP49765
Domaine pattern : Prosite (Expaxy)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domains : Interpro (EBI)Cystine-knot_cytokine    PD_growth_factor_CS    PDGF/VEGF_dom   
Domain families : Pfam (Sanger)PDGF (PF00341)   
Domain families : Pfam (NCBI)pfam00341   
Domain families : Smart (EMBL)PDGF (SM00141)  
Conserved Domain (NCBI)VEGFB
DMDM Disease mutations7423
Blocks (Seattle)VEGFB
PDB (SRS)2C7W    2VWE    2XAC   
PDB (PDBSum)2C7W    2VWE    2XAC   
PDB (IMB)2C7W    2VWE    2XAC   
PDB (RSDB)2C7W    2VWE    2XAC   
Structural Biology KnowledgeBase2C7W    2VWE    2XAC   
SCOP (Structural Classification of Proteins)2C7W    2VWE    2XAC   
CATH (Classification of proteins structures)2C7W    2VWE    2XAC   
SuperfamilyP49765
Human Protein AtlasENSG00000173511
Peptide AtlasP49765
HPRD03237
IPIIPI00028075   IPI00219686   IPI01015098   
Protein Interaction databases
DIP (DOE-UCLA)P49765
IntAct (EBI)P49765
FunCoupENSG00000173511
BioGRIDVEGFB
STRING (EMBL)VEGFB
ZODIACVEGFB
Ontologies - Pathways
QuickGOP49765
Ontology : AmiGOangiogenesis  positive regulation of endothelial cell proliferation  platelet degranulation  protein binding  extracellular region  extracellular space  protein O-linked glycosylation  growth factor activity  heparin binding  negative regulation of gene expression  membrane  positive regulation of vascular endothelial growth factor receptor signaling pathway  platelet alpha granule lumen  positive regulation of vascular wound healing  chemoattractant activity  response to drug  protein homodimerization activity  negative regulation of apoptotic process  positive regulation of vascular permeability  vascular endothelial growth factor receptor 1 binding  negative regulation of neuron apoptotic process  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  induction of positive chemotaxis  positive regulation of cell division  positive regulation of protein kinase B signaling  cardiac muscle contraction  positive regulation of mast cell chemotaxis  coronary vasculature development  positive regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIangiogenesis  positive regulation of endothelial cell proliferation  platelet degranulation  protein binding  extracellular region  extracellular space  protein O-linked glycosylation  growth factor activity  heparin binding  negative regulation of gene expression  membrane  positive regulation of vascular endothelial growth factor receptor signaling pathway  platelet alpha granule lumen  positive regulation of vascular wound healing  chemoattractant activity  response to drug  protein homodimerization activity  negative regulation of apoptotic process  positive regulation of vascular permeability  vascular endothelial growth factor receptor 1 binding  negative regulation of neuron apoptotic process  protein heterodimerization activity  vascular endothelial growth factor receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  induction of positive chemotaxis  positive regulation of cell division  positive regulation of protein kinase B signaling  cardiac muscle contraction  positive regulation of mast cell chemotaxis  coronary vasculature development  positive regulation of ERK1 and ERK2 cascade  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Cytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Focal adhesion    Pathways in cancer   
NDEx NetworkVEGFB
Atlas of Cancer Signalling NetworkVEGFB
Wikipedia pathwaysVEGFB
Orthology - Evolution
OrthoDB7423
GeneTree (enSembl)ENSG00000173511
Phylogenetic Trees/Animal Genes : TreeFamVEGFB
HOVERGENP49765
HOGENOMP49765
Homologs : HomoloGeneVEGFB
Homology/Alignments : Family Browser (UCSC)VEGFB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVEGFB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VEGFB
dbVarVEGFB
ClinVarVEGFB
1000_GenomesVEGFB 
Exome Variant ServerVEGFB
ExAC (Exome Aggregation Consortium)VEGFB (select the gene name)
Genetic variants : HAPMAP7423
Genomic Variants (DGV)VEGFB [DGVbeta]
DECIPHER (Syndromes)11:64002056-64006736  ENSG00000173511
CONAN: Copy Number AnalysisVEGFB 
Mutations
ICGC Data PortalVEGFB 
TCGA Data PortalVEGFB 
Broad Tumor PortalVEGFB
OASIS PortalVEGFB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVEGFB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVEGFB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VEGFB
DgiDB (Drug Gene Interaction Database)VEGFB
DoCM (Curated mutations)VEGFB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VEGFB (select a term)
intoGenVEGFB
Cancer3DVEGFB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601398   
Orphanet
MedgenVEGFB
Genetic Testing Registry VEGFB
NextProtP49765 [Medical]
TSGene7423
GENETestsVEGFB
Huge Navigator VEGFB [HugePedia]
snp3D : Map Gene to Disease7423
BioCentury BCIQVEGFB
ClinGenVEGFB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7423
Chemical/Pharm GKB GenePA37303
Clinical trialVEGFB
Miscellaneous
canSAR (ICR)VEGFB (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVEGFB
EVEXVEGFB
GoPubMedVEGFB
iHOPVEGFB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:33:50 CET 2017

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