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VEGFC (vascular endothelial growth factor C)

Identity

Alias_symbol (synonym)VRP
Other aliasFlt4-L
LMPH1D
HGNC (Hugo) VEGFC
LocusID (NCBI) 7424
Atlas_Id 42789
Location 4q34.3  [Link to chromosome band 4q34]
Location_base_pair Starts at 177604685 and ends at 177713899 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
VEGFC (4q34.3) / GALNTL6 (4q34.1)VEGFC (4q34.3) / VEGFC (4q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)VEGFC   12682
Cards
Entrez_Gene (NCBI)VEGFC  7424  vascular endothelial growth factor C
AliasesFlt4-L; LMPH1D; VRP
GeneCards (Weizmann)VEGFC
Ensembl hg19 (Hinxton)ENSG00000150630 [Gene_View]  chr4:177604685-177713899 [Contig_View]  VEGFC [Vega]
Ensembl hg38 (Hinxton)ENSG00000150630 [Gene_View]  chr4:177604685-177713899 [Contig_View]  VEGFC [Vega]
ICGC DataPortalENSG00000150630
TCGA cBioPortalVEGFC
AceView (NCBI)VEGFC
Genatlas (Paris)VEGFC
WikiGenes7424
SOURCE (Princeton)VEGFC
Genetics Home Reference (NIH)VEGFC
Genomic and cartography
GoldenPath hg19 (UCSC)VEGFC  -     chr4:177604685-177713899 -  4q34.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)VEGFC  -     4q34.3   [Description]    (hg38-Dec_2013)
EnsemblVEGFC - 4q34.3 [CytoView hg19]  VEGFC - 4q34.3 [CytoView hg38]
Mapping of homologs : NCBIVEGFC [Mapview hg19]  VEGFC [Mapview hg38]
OMIM601528   615907   
Gene and transcription
Genbank (Entrez)AK313879 AW294939 BC035212 BC063685 BF528469
RefSeq transcript (Entrez)NM_005429
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_034216 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)VEGFC
Cluster EST : UnigeneHs.435215 [ NCBI ]
CGAP (NCI)Hs.435215
Alternative Splicing GalleryENSG00000150630
Gene ExpressionVEGFC [ NCBI-GEO ]   VEGFC [ EBI - ARRAY_EXPRESS ]   VEGFC [ SEEK ]   VEGFC [ MEM ]
Gene Expression Viewer (FireBrowse)VEGFC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7424
GTEX Portal (Tissue expression)VEGFC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49767   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49767  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49767
Splice isoforms : SwissVarP49767
PhosPhoSitePlusP49767
Domaine pattern : Prosite (Expaxy)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domains : Interpro (EBI)CXCXC_repeat    Cystine-knot_cytokine    PD_growth_factor_CS    PDGF/VEGF_dom   
Domain families : Pfam (Sanger)CXCXC (PF03128)    PDGF (PF00341)   
Domain families : Pfam (NCBI)pfam03128    pfam00341   
Domain families : Smart (EMBL)PDGF (SM00141)  
Conserved Domain (NCBI)VEGFC
DMDM Disease mutations7424
Blocks (Seattle)VEGFC
PDB (SRS)2X1W    2X1X    4BSK   
PDB (PDBSum)2X1W    2X1X    4BSK   
PDB (IMB)2X1W    2X1X    4BSK   
PDB (RSDB)2X1W    2X1X    4BSK   
Structural Biology KnowledgeBase2X1W    2X1X    4BSK   
SCOP (Structural Classification of Proteins)2X1W    2X1X    4BSK   
CATH (Classification of proteins structures)2X1W    2X1X    4BSK   
SuperfamilyP49767
Human Protein AtlasENSG00000150630
Peptide AtlasP49767
HPRD03317
IPIIPI00028076   
Protein Interaction databases
DIP (DOE-UCLA)P49767
IntAct (EBI)P49767
FunCoupENSG00000150630
BioGRIDVEGFC
STRING (EMBL)VEGFC
ZODIACVEGFC
Ontologies - Pathways
QuickGOP49767
Ontology : AmiGOangiogenesis  positive regulation of cell-matrix adhesion  positive regulation of neuroblast proliferation  platelet degranulation  protein binding  extracellular region  extracellular space  substrate-dependent cell migration  signal transduction  growth factor activity  positive regulation of cell proliferation  negative regulation of cell proliferation  organ morphogenesis  membrane  morphogenesis of embryonic epithelium  regulation of vascular endothelial growth factor receptor signaling pathway  platelet alpha granule lumen  positive regulation of protein autophosphorylation  chemoattractant activity  response to drug  vascular endothelial growth factor receptor 3 binding  positive regulation of blood vessel endothelial cell migration  positive regulation of angiogenesis  negative regulation of blood pressure  vascular endothelial growth factor receptor signaling pathway  positive regulation of epithelial cell proliferation  positive regulation of protein secretion  positive regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  induction of positive chemotaxis  positive regulation of cell division  positive regulation of mast cell chemotaxis  positive regulation of lymphangiogenesis  
Ontology : EGO-EBIangiogenesis  positive regulation of cell-matrix adhesion  positive regulation of neuroblast proliferation  platelet degranulation  protein binding  extracellular region  extracellular space  substrate-dependent cell migration  signal transduction  growth factor activity  positive regulation of cell proliferation  negative regulation of cell proliferation  organ morphogenesis  membrane  morphogenesis of embryonic epithelium  regulation of vascular endothelial growth factor receptor signaling pathway  platelet alpha granule lumen  positive regulation of protein autophosphorylation  chemoattractant activity  response to drug  vascular endothelial growth factor receptor 3 binding  positive regulation of blood vessel endothelial cell migration  positive regulation of angiogenesis  negative regulation of blood pressure  vascular endothelial growth factor receptor signaling pathway  positive regulation of epithelial cell proliferation  positive regulation of protein secretion  positive regulation of peptidyl-tyrosine phosphorylation  positive chemotaxis  induction of positive chemotaxis  positive regulation of cell division  positive regulation of mast cell chemotaxis  positive regulation of lymphangiogenesis  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Cytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Focal adhesion    TNF signaling pathway    Pathways in cancer   
NDEx NetworkVEGFC
Atlas of Cancer Signalling NetworkVEGFC
Wikipedia pathwaysVEGFC
Orthology - Evolution
OrthoDB7424
GeneTree (enSembl)ENSG00000150630
Phylogenetic Trees/Animal Genes : TreeFamVEGFC
HOVERGENP49767
HOGENOMP49767
Homologs : HomoloGeneVEGFC
Homology/Alignments : Family Browser (UCSC)VEGFC
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVEGFC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VEGFC
dbVarVEGFC
ClinVarVEGFC
1000_GenomesVEGFC 
Exome Variant ServerVEGFC
ExAC (Exome Aggregation Consortium)VEGFC (select the gene name)
Genetic variants : HAPMAP7424
Genomic Variants (DGV)VEGFC [DGVbeta]
DECIPHER (Syndromes)4:177604685-177713899  ENSG00000150630
CONAN: Copy Number AnalysisVEGFC 
Mutations
ICGC Data PortalVEGFC 
TCGA Data PortalVEGFC 
Broad Tumor PortalVEGFC
OASIS PortalVEGFC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVEGFC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVEGFC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VEGFC
DgiDB (Drug Gene Interaction Database)VEGFC
DoCM (Curated mutations)VEGFC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VEGFC (select a term)
intoGenVEGFC
Cancer3DVEGFC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601528    615907   
Orphanet11478   
MedgenVEGFC
Genetic Testing Registry VEGFC
NextProtP49767 [Medical]
TSGene7424
GENETestsVEGFC
Huge Navigator VEGFC [HugePedia]
snp3D : Map Gene to Disease7424
BioCentury BCIQVEGFC
ClinGenVEGFC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7424
Chemical/Pharm GKB GenePA37304
Clinical trialVEGFC
Miscellaneous
canSAR (ICR)VEGFC (select the gene name)
Probes
Litterature
PubMed357 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVEGFC
EVEXVEGFC
GoPubMedVEGFC
iHOPVEGFC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:33:50 CET 2017

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