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VGLL2 (vestigial like family member 2)

Identity

Alias_namesvestigial like 2 (Drosophila)
vestigial-like family member 2
Other aliasVGL2
VITO1
HGNC (Hugo) VGLL2
LocusID (NCBI) 245806
Atlas_Id 55796
Location 6q22.1  [Link to chromosome band 6q22]
Location_base_pair Starts at 117265558 and ends at 117273565 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(q22;q24) VGLL2/CITED2
t(6;8)(q22;q13) VGLL2/NCOA2


External links

Nomenclature
HGNC (Hugo)VGLL2   20232
Cards
Entrez_Gene (NCBI)VGLL2  245806  vestigial like family member 2
AliasesVGL2; VITO1
GeneCards (Weizmann)VGLL2
Ensembl hg19 (Hinxton)ENSG00000170162 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170162 [Gene_View]  ENSG00000170162 [Sequence]  chr6:117265558-117273565 [Contig_View]  VGLL2 [Vega]
ICGC DataPortalENSG00000170162
TCGA cBioPortalVGLL2
AceView (NCBI)VGLL2
Genatlas (Paris)VGLL2
WikiGenes245806
SOURCE (Princeton)VGLL2
Genetics Home Reference (NIH)VGLL2
Genomic and cartography
GoldenPath hg38 (UCSC)VGLL2  -     chr6:117265558-117273565 +  6q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VGLL2  -     6q22.1   [Description]    (hg19-Feb_2009)
EnsemblVGLL2 - 6q22.1 [CytoView hg19]  VGLL2 - 6q22.1 [CytoView hg38]
Mapping of homologs : NCBIVGLL2 [Mapview hg19]  VGLL2 [Mapview hg38]
OMIM609979   
Gene and transcription
Genbank (Entrez)AJ578053 AK096878 AY056583 BC069316 BC100798
RefSeq transcript (Entrez)NM_153453 NM_182645
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VGLL2
Cluster EST : UnigeneHs.99324 [ NCBI ]
CGAP (NCI)Hs.99324
Alternative Splicing GalleryENSG00000170162
Gene ExpressionVGLL2 [ NCBI-GEO ]   VGLL2 [ EBI - ARRAY_EXPRESS ]   VGLL2 [ SEEK ]   VGLL2 [ MEM ]
Gene Expression Viewer (FireBrowse)VGLL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)245806
GTEX Portal (Tissue expression)VGLL2
Human Protein AtlasENSG00000170162-VGLL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N8G2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N8G2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N8G2
Splice isoforms : SwissVarQ8N8G2
PhosPhoSitePlusQ8N8G2
Domains : Interpro (EBI)Vg_fam   
Domain families : Pfam (Sanger)Vg_Tdu (PF07545)   
Domain families : Pfam (NCBI)pfam07545   
Conserved Domain (NCBI)VGLL2
DMDM Disease mutations245806
Blocks (Seattle)VGLL2
SuperfamilyQ8N8G2
Human Protein Atlas [tissue]ENSG00000170162-VGLL2 [tissue]
Peptide AtlasQ8N8G2
HPRD18282
IPIIPI00167467   IPI00103461   
Protein Interaction databases
DIP (DOE-UCLA)Q8N8G2
IntAct (EBI)Q8N8G2
FunCoupENSG00000170162
BioGRIDVGLL2
STRING (EMBL)VGLL2
ZODIACVGLL2
Ontologies - Pathways
QuickGOQ8N8G2
Ontology : AmiGOtranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription coactivator activity  protein binding  nucleus  cytoplasm  transcription, DNA-templated  skeletal muscle tissue development  protein C-terminus binding  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBItranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding  transcription coactivator activity  protein binding  nucleus  cytoplasm  transcription, DNA-templated  skeletal muscle tissue development  protein C-terminus binding  positive regulation of transcription by RNA polymerase II  
NDEx NetworkVGLL2
Atlas of Cancer Signalling NetworkVGLL2
Wikipedia pathwaysVGLL2
Orthology - Evolution
OrthoDB245806
GeneTree (enSembl)ENSG00000170162
Phylogenetic Trees/Animal Genes : TreeFamVGLL2
HOVERGENQ8N8G2
HOGENOMQ8N8G2
Homologs : HomoloGeneVGLL2
Homology/Alignments : Family Browser (UCSC)VGLL2
Gene fusions - Rearrangements
Fusion : QuiverVGLL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVGLL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VGLL2
dbVarVGLL2
ClinVarVGLL2
1000_GenomesVGLL2 
Exome Variant ServerVGLL2
ExAC (Exome Aggregation Consortium)ENSG00000170162
GNOMAD BrowserENSG00000170162
Genetic variants : HAPMAP245806
Genomic Variants (DGV)VGLL2 [DGVbeta]
DECIPHERVGLL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVGLL2 
Mutations
ICGC Data PortalVGLL2 
TCGA Data PortalVGLL2 
Broad Tumor PortalVGLL2
OASIS PortalVGLL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVGLL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVGLL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VGLL2
DgiDB (Drug Gene Interaction Database)VGLL2
DoCM (Curated mutations)VGLL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VGLL2 (select a term)
intoGenVGLL2
Cancer3DVGLL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609979   
Orphanet
DisGeNETVGLL2
MedgenVGLL2
Genetic Testing Registry VGLL2
NextProtQ8N8G2 [Medical]
TSGene245806
GENETestsVGLL2
Target ValidationVGLL2
Huge Navigator VGLL2 [HugePedia]
snp3D : Map Gene to Disease245806
BioCentury BCIQVGLL2
ClinGenVGLL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD245806
Chemical/Pharm GKB GenePA134881890
Clinical trialVGLL2
Miscellaneous
canSAR (ICR)VGLL2 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVGLL2
EVEXVGLL2
GoPubMedVGLL2
iHOPVGLL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:57:09 CEST 2018

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