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VIL1 (villin 1)

Identity

Alias_namesVIL
Alias_symbol (synonym)D2S1471
Other alias
HGNC (Hugo) VIL1
LocusID (NCBI) 7429
Atlas_Id 51351
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 219283838 and ends at 219314248 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PLCD4 (2q35) / VIL1 (2q35)VIL1 (2q35) / VIL1 (2q35)PLCD4 2q35 / VIL1 2q35

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)VIL1   12690
Cards
Entrez_Gene (NCBI)VIL1  7429  villin 1
AliasesD2S1471; VIL
GeneCards (Weizmann)VIL1
Ensembl hg19 (Hinxton)ENSG00000127831 [Gene_View]  chr2:219283838-219314248 [Contig_View]  VIL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000127831 [Gene_View]  chr2:219283838-219314248 [Contig_View]  VIL1 [Vega]
ICGC DataPortalENSG00000127831
TCGA cBioPortalVIL1
AceView (NCBI)VIL1
Genatlas (Paris)VIL1
WikiGenes7429
SOURCE (Princeton)VIL1
Genetics Home Reference (NIH)VIL1
Genomic and cartography
GoldenPath hg19 (UCSC)VIL1  -     chr2:219283838-219314248 +  2q35   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)VIL1  -     2q35   [Description]    (hg38-Dec_2013)
EnsemblVIL1 - 2q35 [CytoView hg19]  VIL1 - 2q35 [CytoView hg38]
Mapping of homologs : NCBIVIL1 [Mapview hg19]  VIL1 [Mapview hg38]
OMIM193040   
Gene and transcription
Genbank (Entrez)A14103 AK223398 AK300965 AK313709 BC017303
RefSeq transcript (Entrez)NM_007127
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)VIL1
Cluster EST : UnigeneHs.654595 [ NCBI ]
CGAP (NCI)Hs.654595
Alternative Splicing GalleryENSG00000127831
Gene ExpressionVIL1 [ NCBI-GEO ]   VIL1 [ EBI - ARRAY_EXPRESS ]   VIL1 [ SEEK ]   VIL1 [ MEM ]
Gene Expression Viewer (FireBrowse)VIL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7429
GTEX Portal (Tissue expression)VIL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09327   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09327  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09327
Splice isoforms : SwissVarP09327
PhosPhoSitePlusP09327
Domaine pattern : Prosite (Expaxy)HP (PS51089)   
Domains : Interpro (EBI)ADF-H/Gelsolin-like_dom    Gelsolin-like_dom    Villin    Villin/Gelsolin    Villin_headpiece   
Domain families : Pfam (Sanger)Gelsolin (PF00626)    VHP (PF02209)   
Domain families : Pfam (NCBI)pfam00626    pfam02209   
Domain families : Smart (EMBL)GEL (SM00262)  VHP (SM00153)  
Conserved Domain (NCBI)VIL1
DMDM Disease mutations7429
Blocks (Seattle)VIL1
PDB (SRS)1UNC    3FG7   
PDB (PDBSum)1UNC    3FG7   
PDB (IMB)1UNC    3FG7   
PDB (RSDB)1UNC    3FG7   
Structural Biology KnowledgeBase1UNC    3FG7   
SCOP (Structural Classification of Proteins)1UNC    3FG7   
CATH (Classification of proteins structures)1UNC    3FG7   
SuperfamilyP09327
Human Protein AtlasENSG00000127831
Peptide AtlasP09327
HPRD01898
IPIIPI00218852   IPI00926721   IPI00742948   IPI00927249   IPI00926559   
Protein Interaction databases
DIP (DOE-UCLA)P09327
IntAct (EBI)P09327
FunCoupENSG00000127831
BioGRIDVIL1
STRING (EMBL)VIL1
ZODIACVIL1
Ontologies - Pathways
QuickGOP09327
Ontology : AmiGOruffle  intestinal D-glucose absorption  calcium ion binding  calcium ion binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  nucleoplasm  cytoplasm  plasma membrane  microvillus  brush border  protein complex assembly  epidermal growth factor receptor signaling pathway  regulation of cell shape  response to bacterium  positive regulation of epithelial cell migration  positive regulation of epithelial cell migration  positive regulation of epithelial cell migration  lamellipodium  actin filament polymerization  actin filament depolymerization  filopodium  positive regulation of cell migration  positive regulation of actin filament depolymerization  epithelial cell differentiation  positive regulation of actin filament bundle assembly  actin filament bundle  filopodium tip  regulation of microvillus length  lysophosphatidic acid binding  cellular response to hepatocyte growth factor stimulus  positive regulation of multicellular organism growth  identical protein binding  protein homodimerization activity  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  actin nucleation  actin filament severing  actin filament binding  barbed-end actin filament capping  regulation of actin nucleation  actin filament capping  cytoplasmic actin-based contraction involved in cell motility  regulation of wound healing  extracellular exosome  cellular response to epidermal growth factor stimulus  positive regulation of establishment of protein localization to plasma membrane  terminal web assembly  regulation of lamellipodium morphogenesis  positive regulation of lamellipodium morphogenesis  positive regulation of lamellipodium morphogenesis  
Ontology : EGO-EBIruffle  intestinal D-glucose absorption  calcium ion binding  calcium ion binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  nucleoplasm  cytoplasm  plasma membrane  microvillus  brush border  protein complex assembly  epidermal growth factor receptor signaling pathway  regulation of cell shape  response to bacterium  positive regulation of epithelial cell migration  positive regulation of epithelial cell migration  positive regulation of epithelial cell migration  lamellipodium  actin filament polymerization  actin filament depolymerization  filopodium  positive regulation of cell migration  positive regulation of actin filament depolymerization  epithelial cell differentiation  positive regulation of actin filament bundle assembly  actin filament bundle  filopodium tip  regulation of microvillus length  lysophosphatidic acid binding  cellular response to hepatocyte growth factor stimulus  positive regulation of multicellular organism growth  identical protein binding  protein homodimerization activity  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  actin nucleation  actin filament severing  actin filament binding  barbed-end actin filament capping  regulation of actin nucleation  actin filament capping  cytoplasmic actin-based contraction involved in cell motility  regulation of wound healing  extracellular exosome  cellular response to epidermal growth factor stimulus  positive regulation of establishment of protein localization to plasma membrane  terminal web assembly  regulation of lamellipodium morphogenesis  positive regulation of lamellipodium morphogenesis  positive regulation of lamellipodium morphogenesis  
NDEx NetworkVIL1
Atlas of Cancer Signalling NetworkVIL1
Wikipedia pathwaysVIL1
Orthology - Evolution
OrthoDB7429
GeneTree (enSembl)ENSG00000127831
Phylogenetic Trees/Animal Genes : TreeFamVIL1
HOVERGENP09327
HOGENOMP09327
Homologs : HomoloGeneVIL1
Homology/Alignments : Family Browser (UCSC)VIL1
Gene fusions - Rearrangements
Fusion: TCGAPLCD4 2q35 VIL1 2q35 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVIL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VIL1
dbVarVIL1
ClinVarVIL1
1000_GenomesVIL1 
Exome Variant ServerVIL1
ExAC (Exome Aggregation Consortium)VIL1 (select the gene name)
Genetic variants : HAPMAP7429
Genomic Variants (DGV)VIL1 [DGVbeta]
DECIPHER (Syndromes)2:219283838-219314248  ENSG00000127831
CONAN: Copy Number AnalysisVIL1 
Mutations
ICGC Data PortalVIL1 
TCGA Data PortalVIL1 
Broad Tumor PortalVIL1
OASIS PortalVIL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVIL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVIL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VIL1
DgiDB (Drug Gene Interaction Database)VIL1
DoCM (Curated mutations)VIL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VIL1 (select a term)
intoGenVIL1
Cancer3DVIL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM193040   
Orphanet
MedgenVIL1
Genetic Testing Registry VIL1
NextProtP09327 [Medical]
TSGene7429
GENETestsVIL1
Huge Navigator VIL1 [HugePedia]
snp3D : Map Gene to Disease7429
BioCentury BCIQVIL1
ClinGenVIL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7429
Chemical/Pharm GKB GenePA37309
Clinical trialVIL1
Miscellaneous
canSAR (ICR)VIL1 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVIL1
EVEXVIL1
GoPubMedVIL1
iHOPVIL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:33:53 CET 2017

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