VIPR2 (vasoactive intestinal peptide receptor 2)

2012-01-01  

Identity

HGNC
LOCATION
7q36.3
LOCUSID
ALIAS
C16DUPq36.3,DUP7q36.3,PACAP-R-3,PACAP-R3,VIP-R-2,VPAC2,VPAC2R,VPCAP2R
FUSION GENES

Other Information

Locus ID:

NCBI: 7434
MIM: 601970
HGNC: 12695
Ensembl: ENSG00000106018

Variants:

dbSNP: 7434
ClinVar: 7434
TCGA: ENSG00000106018
COSMIC: VIPR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106018ENST00000262178P41587
ENSG00000106018ENST00000262178X5D7Q6
ENSG00000106018ENST00000377633P41587
ENSG00000106018ENST00000402066C9JCP7
ENSG00000106018ENST00000421760E9PCR5

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
205546942010Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.45
194701682009NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.42
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
183833832008Differential expression of vasoactive intestinal peptide and its functional receptors in human osteoarthritic and rheumatoid synovial fibroblasts.27
150900462004Transgenic approach reveals expression of the VPAC2 receptor in phenotypically defined neurons in the mouse suprachiasmatic nucleus and in its efferent target sites.23
170771782006Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis.23
263040332016Methylomic analysis of salivary DNA in childhood ADHD identifies altered DNA methylation in VIPR2.23
203791462010Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.22
206917432010Nuclear localization of vasoactive intestinal peptide (VIP) receptors in human breast cancer.21

Citation

Dessen P

VIPR2 (vasoactive intestinal peptide receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52563/vipr2