Atlas of Genetics and Cytogenetics in Oncology and Haematology


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VKORC1 (vitamin K epoxide reductase complex subunit 1)

Identity

Alias_namesVKCFD2
vitamin K dependent clotting factors deficiency 2
Other aliasEDTP308
MST134
MST576
VKOR
HGNC (Hugo) VKORC1
LocusID (NCBI) 79001
Atlas_Id 50786
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31102163 and ends at 31106320 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)VKORC1   23663
LRG (Locus Reference Genomic)LRG_582
Cards
Entrez_Gene (NCBI)VKORC1  79001  vitamin K epoxide reductase complex subunit 1
AliasesEDTP308; MST134; MST576; VKCFD2; 
VKOR
GeneCards (Weizmann)VKORC1
Ensembl hg19 (Hinxton)ENSG00000167397 [Gene_View]  chr16:31102163-31106320 [Contig_View]  VKORC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167397 [Gene_View]  chr16:31102163-31106320 [Contig_View]  VKORC1 [Vega]
ICGC DataPortalENSG00000167397
TCGA cBioPortalVKORC1
AceView (NCBI)VKORC1
Genatlas (Paris)VKORC1
WikiGenes79001
SOURCE (Princeton)VKORC1
Genetics Home Reference (NIH)VKORC1
Genomic and cartography
GoldenPath hg19 (UCSC)VKORC1  -     chr16:31102163-31106320 -  16p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)VKORC1  -     16p11.2   [Description]    (hg38-Dec_2013)
EnsemblVKORC1 - 16p11.2 [CytoView hg19]  VKORC1 - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBIVKORC1 [Mapview hg19]  VKORC1 [Mapview hg38]
OMIM122700   607473   608547   
Gene and transcription
Genbank (Entrez)AF176924 AK125618 AK129513 AK289790 AK312005
RefSeq transcript (Entrez)NM_001311311 NM_024006 NM_206824
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_011564 NT_187260 NW_004929400
Consensus coding sequences : CCDS (NCBI)VKORC1
Cluster EST : UnigeneHs.324844 [ NCBI ]
CGAP (NCI)Hs.324844
Alternative Splicing GalleryENSG00000167397
Gene ExpressionVKORC1 [ NCBI-GEO ]   VKORC1 [ EBI - ARRAY_EXPRESS ]   VKORC1 [ SEEK ]   VKORC1 [ MEM ]
Gene Expression Viewer (FireBrowse)VKORC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79001
GTEX Portal (Tissue expression)VKORC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQB6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQB6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQB6
Splice isoforms : SwissVarQ9BQB6
PhosPhoSitePlusQ9BQB6
Domains : Interpro (EBI)VKOR   
Domain families : Pfam (Sanger)VKOR (PF07884)   
Domain families : Pfam (NCBI)pfam07884   
Domain families : Smart (EMBL)VKc (SM00756)  
Conserved Domain (NCBI)VKORC1
DMDM Disease mutations79001
Blocks (Seattle)VKORC1
SuperfamilyQ9BQB6
Human Protein AtlasENSG00000167397
Peptide AtlasQ9BQB6
HPRD10540
IPIIPI00031000   IPI00384902   IPI00410112   IPI00797868   IPI00797645   IPI00796570   IPI00983113   IPI00984432   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQB6
IntAct (EBI)Q9BQB6
FunCoupENSG00000167397
BioGRIDVKORC1
STRING (EMBL)VKORC1
ZODIACVKORC1
Ontologies - Pathways
QuickGOQ9BQB6
Ontology : AmiGOendoplasmic reticulum membrane  blood coagulation  integral component of membrane  drug metabolic process  peptidyl-glutamic acid carboxylation  vitamin K metabolic process  vitamin K metabolic process  vitamin-K-epoxide reductase (warfarin-sensitive) activity  vitamin-K-epoxide reductase (warfarin-sensitive) activity  quinone binding  oxidation-reduction process  bone development  
Ontology : EGO-EBIendoplasmic reticulum membrane  blood coagulation  integral component of membrane  drug metabolic process  peptidyl-glutamic acid carboxylation  vitamin K metabolic process  vitamin K metabolic process  vitamin-K-epoxide reductase (warfarin-sensitive) activity  vitamin-K-epoxide reductase (warfarin-sensitive) activity  quinone binding  oxidation-reduction process  bone development  
Pathways : KEGGUbiquinone and other terpenoid-quinone biosynthesis   
NDEx NetworkVKORC1
Atlas of Cancer Signalling NetworkVKORC1
Wikipedia pathwaysVKORC1
Orthology - Evolution
OrthoDB79001
GeneTree (enSembl)ENSG00000167397
Phylogenetic Trees/Animal Genes : TreeFamVKORC1
HOVERGENQ9BQB6
HOGENOMQ9BQB6
Homologs : HomoloGeneVKORC1
Homology/Alignments : Family Browser (UCSC)VKORC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVKORC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VKORC1
dbVarVKORC1
ClinVarVKORC1
1000_GenomesVKORC1 
Exome Variant ServerVKORC1
ExAC (Exome Aggregation Consortium)VKORC1 (select the gene name)
Genetic variants : HAPMAP79001
Genomic Variants (DGV)VKORC1 [DGVbeta]
DECIPHER (Syndromes)16:31102163-31106320  ENSG00000167397
CONAN: Copy Number AnalysisVKORC1 
Mutations
ICGC Data PortalVKORC1 
TCGA Data PortalVKORC1 
Broad Tumor PortalVKORC1
OASIS PortalVKORC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVKORC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVKORC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VKORC1
DgiDB (Drug Gene Interaction Database)VKORC1
DoCM (Curated mutations)VKORC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VKORC1 (select a term)
intoGenVKORC1
Cancer3DVKORC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM122700    607473    608547   
Orphanet23060    23062    13451   
MedgenVKORC1
Genetic Testing Registry VKORC1
NextProtQ9BQB6 [Medical]
TSGene79001
GENETestsVKORC1
Huge Navigator VKORC1 [HugePedia]
snp3D : Map Gene to Disease79001
BioCentury BCIQVKORC1
ClinGenVKORC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79001
Chemical/Pharm GKB GenePA133787052
Clinical trialVKORC1
Miscellaneous
canSAR (ICR)VKORC1 (select the gene name)
Probes
Litterature
PubMed342 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVKORC1
EVEXVKORC1
GoPubMedVKORC1
iHOPVKORC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:24:47 CEST 2017

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