VKORC1 (vitamin K epoxide reductase complex subunit 1)

2009-03-01 Affiliation

Identity

HGNC

VKORC1

LOCATION

16p11.2

LOCUSID

79001

ALIAS

EDTP308,MST134,MST576,VKCFD2,VKOR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79001
MIM: 608547
HGNC: 23663
Ensembl: ENSG00000167397

Variants:

dbSNP: 79001
ClinVar: 79001
TCGA: ENSG00000167397
COSMIC: VKORC1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000167397	ENST00000300851	F8W9H0
ENSG00000167397	ENST00000319788	Q9BQB6
ENSG00000167397	ENST00000354895	Q9BQB6
ENSG00000167397	ENST00000354895	A0A0S2Z5X7
ENSG00000167397	ENST00000394971	A8MV79
ENSG00000167397	ENST00000394975	Q9BQB6
ENSG00000167397	ENST00000394975	A0A0S2Z6I4
ENSG00000167397	ENST00000420057	H0YF24
ENSG00000167397	ENST00000472468	I3L1P9
ENSG00000167397	ENST00000498155	F2Z3Q2

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquinone and other terpenoid-quinone biosynthesis	KEGG	ko00130
Ubiquinone and other terpenoid-quinone biosynthesis	KEGG	hsa00130
Metabolism	REACTOME	R-HSA-1430728
Metabolism of vitamins and cofactors	REACTOME	R-HSA-196854
Metabolism of fat-soluble vitamins	REACTOME	R-HSA-6806667
Metabolism of vitamin K	REACTOME	R-HSA-6806664

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA126	CYP2C9	Gene	DataAnnotation, VipGene	associated			12931134, 14765194, 14765195, 15358623, 15597574, 15865594, 15930419, 15938684, 16888441, 16960144, 16983400, 17124101, 9684798, 11926893
PA153619833	Peripheral Vascular Diseases	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA165816542	CYP2C9*1	Haplotype	LabelAnnotation	associated
PA165816543	CYP2C9*2	Haplotype	GuidelineAnnotation, LabelAnnotation	associated
PA165816544	CYP2C9*3	Haplotype	GuidelineAnnotation, LabelAnnotation	associated
PA165816546	CYP2C9*5	Haplotype	GuidelineAnnotation	associated
PA165816547	CYP2C9*6	Haplotype	GuidelineAnnotation	associated
PA165816549	CYP2C9*8	Haplotype	GuidelineAnnotation	associated
PA165816552	CYP2C9*11	Haplotype	GuidelineAnnotation	associated
PA165816594	VKORC1*1	Haplotype	VipGene	associated			16270629
PA165816595	VKORC1*2	Haplotype	VipGene	associated			16270629, 15930419
PA165816596	VKORC1*3	Haplotype	VipGene	associated			15930419, 16270629, 15358623
PA165816597	VKORC1*4	Haplotype	VipGene	associated			15930419, 16270629, 16676068, 15358623
PA165980614	fluindione	Chemical	ClinicalAnnotation, GuidelineAnnotation	associated		PD	21883387
PA166123298	over-anticoagulation	Disease	ClinicalAnnotation	associated		PD	18690342, 19794411, 21318593, 22571356, 22990331, 23104259, 23279643, 23602689, 23932037, 25769357, 26445138, 28049362
PA166129531	time in therapeutic range	Disease	ClinicalAnnotation	associated		PD	18690342, 22592842, 29396738
PA166154157	rs12777823	Variant	GuidelineAnnotation	associated
PA166154977	rs7294	Variant	VipGene	associated			15883587, 16270629, 16424822, 16432637, 16580898, 16676068, 16879214, 17031720, 17049586, 15358623
PA166155091	rs9923231	Variant	GuidelineAnnotation, LabelAnnotation, VipGene	associated			15883587, 15888487, 15930419, 15947090, 16141794, 16270629, 16432637, 16580898, 16611310, 16890578, 17049586, 17161452, 15790782
PA166155096	rs9934438	Variant	GuidelineAnnotation, VipGene	associated			15790782, 15883587, 16270629, 16424822, 16432637, 16676068, 16700826, 16815313, 16879214, 16890578, 17031720, 17049586, 17111199, 15358623
PA166155381	rs2108622	Variant	GuidelineAnnotation	associated
PA27121	CYP4F2	Gene	DataAnnotation	associated
PA28660	GGCX	Gene	DataAnnotation	associated
PA443425	Arteriosclerosis	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA443459	Atrial Fibrillation	Disease	ClinicalAnnotation, VipGene	associated		PD	18574025, 18690342, 18950464, 21148049, 22571356, 22592842, 23423913, 23602689, 23774101, 24474498, 24919870, 25001883, 25244877, 25521356, 25769357, 26445138, 26777610, 27262824, 27488176, 27581200, 28033245, 28689179, 29432897, 29577257
PA444368	Heart Diseases	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA444417	Hemorrhage	Disease	ClinicalAnnotation, VipGene	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA445465	Pulmonary Embolism	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA445848	Thromboembolism	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21883387, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA446021	Vascular Diseases	Disease	VipGene	associated
PA446900	Coagulation Protein Disorders	Disease	VipGene	associated
PA446969	Venous Thrombosis	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA446997	Intracranial Hemorrhages	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 19077919, 19177029, 20585834, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 23159229, 23183958, 24019055, 25026456, 25989350, 26223945, 26257249, 26433837, 27121899, 28262345, 29054760, 31653973
PA447054	Stroke	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 18574025, 18690342, 18950464, 19077919, 19177029, 20585834, 21148049, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 22571356, 22592842, 23159229, 23183958, 23423913, 23602689, 23774101, 24019055, 24474498, 24919870, 25001883, 25026456, 25244877, 25521356, 25769357, 25989350, 26223945, 26257249, 26433837, 26445138, 26777610, 27121899, 27262824, 27488176, 27581200, 28033245, 28262345, 28689179, 29054760, 29432897, 29577257, 31653973
PA447298	venous thromboembolism	Disease	ClinicalAnnotation	associated	PK	PD	15358623, 15883587, 16270629, 16432637, 16676068, 16821005, 17031720, 17111199, 17329985, 17391071, 17989110, 18030307, 18240904, 18574025, 18690342, 18950464, 19077919, 19177029, 20585834, 21148049, 21176721, 21273734, 21326313, 21981797, 22075505, 22248286, 22534826, 22549502, 22571356, 22592842, 23159229, 23183958, 23423913, 23602689, 23774101, 24019055, 24474498, 24919870, 25001883, 25026456, 25244877, 25521356, 25769357, 25989350, 26223945, 26257249, 26433837, 26445138, 26777610, 27121899, 27262824, 27488176, 27581200, 28033245, 28262345, 28689179, 29054760, 29432897, 29577257, 31653973
PA450921	phenprocoumon	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, MultilinkAnnotation, VipGene	associated		PD	16611310, 16815313, 17596133, 18574025, 18629445, 18690342, 18698879, 18781852, 18950464, 19018719, 19225451, 19270263, 19277427, 19875892, 20020283, 20376629, 20833980, 21057703, 21110013, 21148049, 21636598, 22486182, 22571356, 22592842, 22629463, 22911785, 22920394, 23159639, 23299853, 23423913, 23473641, 23481074, 23602689, 23651023, 23774101, 23774941, 24108193, 24224579, 24474498, 24919870, 24956252, 25001883, 25042728, 25089947, 25244877, 25519826, 25521356, 25769357, 26445138, 26777610, 26984978, 27262824, 27335128, 27488176, 27581200, 28033245, 28689179, 29432897, 29577257, 30983536
PA451906	warfarin	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation, VipGene	associated	PK	PD	11926893, 12931134, 14676821, 14765194, 14765195, 15358623, 15597574, 15790782, 15865594, 15883587, 15888487, 15930419, 15938684, 15947090, 16141794, 16270629, 16432637, 16493479, 16580898, 16611310, 16676068, 16815312, 16815313, 16847429, 16888441, 16890578, 16960144, 16983400, 17015052, 17042764, 17049586, 17111199, 17112295, 17124101, 17161452, 17189218, 17906972, 9684798, 11127854, 14765194, 15358623, 15883587, 15888487, 15930419, 15947090, 16270629, 16432637, 16493479, 16580898, 16611750, 16676068, 16821005, 16890578, 16983400, 17031720, 17049586, 17110455, 17111199, 17329985, 17391071, 17456829, 17510308, 17989110, 18030307, 18234403, 18240904, 18466099, 18542936, 18574025, 18690342, 18698879, 18752379, 18950464, 19077919, 19135231, 19177029, 19297219, 19387626, 19582440, 19745563, 19794411, 19874474, 19875892, 20072124, 20203262, 20339978, 20386359, 20410877, 20421126, 20585834, 20615525, 20833655, 20833980, 21110192, 21148049, 21174619, 21176721, 21185752, 21273734, 21318593, 21326313, 21383771, 21635147, 21900891, 21981797, 22010099, 22040439, 22075505, 22248286, 22349464, 22528326, 22534826, 22549502, 22571356, 22592842, 22616655, 22676192, 22854539, 22990331, 23061746, 23104259, 23159229, 23183958, 23208322, 23279643, 23423913, 23602689, 23774101, 23932037, 23949431, 24019055, 24029542, 24330000, 24474498, 24728385, 24919870, 25001883, 25026456, 25042728, 25084205, 25244877, 25312789, 25519826, 25521356, 25594941, 25769357, 25989350, 26219158, 26223945, 26257249, 26433837, 26445138, 26777610, 27121899, 27262824, 27488176, 27581200, 28033245, 28049362, 28262345, 28382498, 28429387, 28689179, 29054760, 29298995, 29396738, 29432897, 29577257, 29781049, 31395958, 31653973
PA452632	acenocoumarol	Chemical	ClinicalAnnotation, DataAnnotation, GuidelineAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene	associated		PD	16611310, 16815313, 17596133, 18574025, 18629445, 18690342, 18698879, 18781852, 18950464, 19018719, 19225451, 19270263, 19277427, 19875892, 20020283, 20376629, 20833980, 21057703, 21110013, 21148049, 21636598, 22486182, 22571356, 22592842, 22629463, 22911785, 22920394, 23159639, 23299853, 23423913, 23473641, 23481074, 23602689, 23651023, 23774101, 23774941, 24108193, 24224579, 24474498, 24919870, 24956252, 25001883, 25042728, 25089947, 25244877, 25519826, 25521356, 25769357, 26445138, 26777610, 26984978, 27262824, 27335128, 27488176, 27581200, 28033245, 28689179, 29432897, 29479633, 29577257, 30983536
PA55	APOE	Gene	DataAnnotation	associated

References

Pubmed ID	Year	Title	Citations
38056237	2024	New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/PD model.	0
38674033	2024	Is a Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism a Risk Factor for Nephrolithiasis in Sarcoidosis?	0
38056237	2024	New insights into the role of VKORC1 polymorphisms for optimal warfarin dose selection in Caribbean Hispanic patients through an external validation of a population PK/PD model.	0
38674033	2024	Is a Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism a Risk Factor for Nephrolithiasis in Sarcoidosis?	0
36125842	2023	Association of VKORC1 polymorphisms and major bleedings in patients who are treated with vitamin K antagonists.	2
36508285	2023	Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state.	1
36942299	2023	The role of CYP2C92, CYP2C93 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study.	3
37419479	2023	FREQUENCY OF VKORC1 AND CYP2C9 GENES POLYMORPHISM IN ABKHAZIAN POPULATION.	0
37505171	2023	Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.	0
37653796	2023	Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke.	0
36125842	2023	Association of VKORC1 polymorphisms and major bleedings in patients who are treated with vitamin K antagonists.	2
36508285	2023	Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state.	1
36942299	2023	The role of CYP2C92, CYP2C93 and VKORC1-1639 variants on the susceptibility of upper gastrointestinal bleeding: A full case-control study.	3
37419479	2023	FREQUENCY OF VKORC1 AND CYP2C9 GENES POLYMORPHISM IN ABKHAZIAN POPULATION.	0
37505171	2023	Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.	0

Citation

Dessen P

VKORC1 (vitamin K epoxide reductase complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50786/vkorc1

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