Atlas of Genetics and Cytogenetics in Oncology and Haematology

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VPS18 (VPS18 core subunit of CORVET and HOPS complexes)

Identity

Alias (NCBI)PEP3
HGNC (Hugo) VPS18
HGNC Alias symbKIAA1475
PEP3
HGNC Previous namevacuolar protein sorting protein 18
 vacuolar protein sorting 18 homolog (S. cerevisiae)
LocusID (NCBI) 57617
Atlas_Id 75628
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 40894430 and ends at 40903975 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
VPS18 (15q15.1) / VPS18 (15q15.1)VPS18 (15q15.1) / ZFYVE19 (15q15.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)VPS18   15972
Cards
Entrez_Gene (NCBI)VPS18  57617  VPS18 core subunit of CORVET and HOPS complexes
AliasesPEP3
GeneCards (Weizmann)VPS18
Ensembl hg19 (Hinxton)ENSG00000104142 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104142 [Gene_View]  ENSG00000104142 [Sequence]  chr15:40894430-40903975 [Contig_View]  VPS18 [Vega]
ICGC DataPortalENSG00000104142
TCGA cBioPortalVPS18
AceView (NCBI)VPS18
Genatlas (Paris)VPS18
WikiGenes57617
SOURCE (Princeton)VPS18
Genetics Home Reference (NIH)VPS18
Genomic and cartography
GoldenPath hg38 (UCSC)VPS18  -     chr15:40894430-40903975 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VPS18  -     15q15.1   [Description]    (hg19-Feb_2009)
GoldenPathVPS18 - 15q15.1 [CytoView hg19]  VPS18 - 15q15.1 [CytoView hg38]
ImmunoBaseENSG00000104142
genome Data Viewer NCBIVPS18 [Mapview hg19]  
OMIM608551   
Gene and transcription
Genbank (Entrez)AB040908 AF308802 AL713725 BC001513
RefSeq transcript (Entrez)NM_020857
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VPS18
Alternative Splicing GalleryENSG00000104142
Gene ExpressionVPS18 [ NCBI-GEO ]   VPS18 [ EBI - ARRAY_EXPRESS ]   VPS18 [ SEEK ]   VPS18 [ MEM ]
Gene Expression Viewer (FireBrowse)VPS18 [ Firebrowse - Broad ]
GenevisibleExpression of VPS18 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57617
GTEX Portal (Tissue expression)VPS18
Human Protein AtlasENSG00000104142-VPS18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P253   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P253  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P253
Splice isoforms : SwissVarQ9P253
PhosPhoSitePlusQ9P253
Domaine pattern : Prosite (Expaxy)CHCR (PS50236)   
Domains : Interpro (EBI)Clathrin_H-chain/VPS_repeat    Pep3_Vps18   
Domain families : Pfam (Sanger)Clathrin (PF00637)    Pep3_Vps18 (PF05131)   
Domain families : Pfam (NCBI)pfam00637    pfam05131   
Conserved Domain (NCBI)VPS18
DMDM Disease mutations57617
Blocks (Seattle)VPS18
SuperfamilyQ9P253
Human Protein Atlas [tissue]ENSG00000104142-VPS18 [tissue]
Peptide AtlasQ9P253
HPRD09776
IPIIPI00001985   
Protein Interaction databases
DIP (DOE-UCLA)Q9P253
IntAct (EBI)Q9P253
FunCoupENSG00000104142
BioGRIDVPS18
STRING (EMBL)VPS18
ZODIACVPS18
Ontologies - Pathways
QuickGOQ9P253
Ontology : AmiGOactin binding  protein binding  lysosome  lysosomal membrane  endosome  early endosome  late endosome  autophagosome  actin filament  intracellular protein transport  vesicle docking involved in exocytosis  autophagy  endosome organization  endosome organization  vacuole organization  lysosome organization  lysosome organization  endosome to lysosome transport  syntaxin binding  AP-3 adaptor complex  clathrin-coated vesicle  protein binding, bridging  HOPS complex  HOPS complex  late endosome membrane  CORVET complex  regulation of SNARE complex assembly  viral entry into host cell  metal ion binding  presynapse  glutamatergic synapse  glutamatergic synapse  glutamatergic synapse  regulation of synaptic vesicle exocytosis  regulation of synaptic vesicle exocytosis  regulation of synaptic vesicle exocytosis  
Ontology : EGO-EBIactin binding  protein binding  lysosome  lysosomal membrane  endosome  early endosome  late endosome  autophagosome  actin filament  intracellular protein transport  vesicle docking involved in exocytosis  autophagy  endosome organization  endosome organization  vacuole organization  lysosome organization  lysosome organization  endosome to lysosome transport  syntaxin binding  AP-3 adaptor complex  clathrin-coated vesicle  protein binding, bridging  HOPS complex  HOPS complex  late endosome membrane  CORVET complex  regulation of SNARE complex assembly  viral entry into host cell  metal ion binding  presynapse  glutamatergic synapse  glutamatergic synapse  glutamatergic synapse  regulation of synaptic vesicle exocytosis  regulation of synaptic vesicle exocytosis  regulation of synaptic vesicle exocytosis  
NDEx NetworkVPS18
Atlas of Cancer Signalling NetworkVPS18
Wikipedia pathwaysVPS18
Orthology - Evolution
OrthoDB57617
GeneTree (enSembl)ENSG00000104142
Phylogenetic Trees/Animal Genes : TreeFamVPS18
HOGENOMQ9P253
Homologs : HomoloGeneVPS18
Homology/Alignments : Family Browser (UCSC)VPS18
Gene fusions - Rearrangements
Fusion : QuiverVPS18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVPS18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VPS18
dbVarVPS18
ClinVarVPS18
1000_GenomesVPS18 
Exome Variant ServerVPS18
GNOMAD BrowserENSG00000104142
Varsome BrowserVPS18
Genetic variants : HAPMAP57617
Genomic Variants (DGV)VPS18 [DGVbeta]
DECIPHERVPS18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVPS18 
Mutations
ICGC Data PortalVPS18 
TCGA Data PortalVPS18 
Broad Tumor PortalVPS18
OASIS PortalVPS18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVPS18  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVPS18
Mutations and Diseases : HGMDVPS18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VPS18
DgiDB (Drug Gene Interaction Database)VPS18
DoCM (Curated mutations)VPS18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VPS18 (select a term)
intoGenVPS18
Cancer3DVPS18(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608551   
Orphanet
DisGeNETVPS18
MedgenVPS18
Genetic Testing Registry VPS18
NextProtQ9P253 [Medical]
TSGene57617
GENETestsVPS18
Target ValidationVPS18
Huge Navigator VPS18 [HugePedia]
snp3D : Map Gene to Disease57617
BioCentury BCIQVPS18
ClinGenVPS18
Clinical trials, drugs, therapy
Protein Interactions : CTD57617
Pharm GKB GenePA38069
Clinical trialVPS18
Miscellaneous
canSAR (ICR)VPS18 (select the gene name)
HarmonizomeVPS18
DataMed IndexVPS18
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVPS18
EVEXVPS18
GoPubMedVPS18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:35:11 CEST 2020
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