VPS18 (VPS18 core subunit of CORVET and HOPS complexes)

2014-11-01  

Identity

HGNC
VPS18
LOCATION
15q15.1
LOCUSID
57617
ALIAS
PEP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57617
MIM: 608551
HGNC: 15972
Ensembl: ENSG00000104142

Variants:

dbSNP: 57617
ClinVar: 57617
TCGA: ENSG00000104142
COSMIC: VPS18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104142ENST00000220509Q9P253
ENSG00000104142ENST00000220509A0A024R9R3
ENSG00000104142ENST00000558474H0YMC9
ENSG00000104142ENST00000558855H0YLM6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
169960302006Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability.15
162037302005Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.11
214508272011The cellular factors Vps18 and Mon2 are required for efficient production of infectious HIV-1 particles.8
289317242017VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction.5
310154282019Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling.0

Citation

Dessen P

VPS18 (VPS18 core subunit of CORVET and HOPS complexes)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75628/vps18