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VPS26A (VPS26, retromer complex component A)

Identity

Alias_namesVPS26
vacuolar protein sorting 26 (yeast homolog)
vacuolar protein sorting 26 homolog A (S. pombe)
Alias_symbol (synonym)Hbeta58
PEP8A
Other aliasHB58
HGNC (Hugo) VPS26A
LocusID (NCBI) 9559
Atlas_Id 75630
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 69124153 and ends at 69174416 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GLUD1 (10q23.2) / VPS26A (10q22.1)SPATA1 (1p22.3) / VPS26A (10q22.1)SUPV3L1 (10q22.1) / VPS26A (10q22.1)
TSPAN15 (10q22.1) / VPS26A (10q22.1)VPS26A (10q22.1) / ATAD1 (10q23.31)VPS26A (10q22.1) / GDAP1L1 (20q13.12)
VPS26A (10q22.1) / GYS1 (19q13.33)VPS26A (10q22.1) / KIF1BP (10q22.1)VPS26A (10q22.1) / NIPBL (5p13.2)
VPS26A (10q22.1) / VPS26A (10q22.1)TSPAN15 VPS26ASUPV3L1 VPS26A

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)VPS26A   12711
Cards
Entrez_Gene (NCBI)VPS26A  9559  VPS26, retromer complex component A
AliasesHB58; Hbeta58; PEP8A; VPS26
GeneCards (Weizmann)VPS26A
Ensembl hg19 (Hinxton)ENSG00000122958 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122958 [Gene_View]  chr10:69124153-69174416 [Contig_View]  VPS26A [Vega]
ICGC DataPortalENSG00000122958
TCGA cBioPortalVPS26A
AceView (NCBI)VPS26A
Genatlas (Paris)VPS26A
WikiGenes9559
SOURCE (Princeton)VPS26A
Genetics Home Reference (NIH)VPS26A
Genomic and cartography
GoldenPath hg38 (UCSC)VPS26A  -     chr10:69124153-69174416 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VPS26A  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblVPS26A - 10q22.1 [CytoView hg19]  VPS26A - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBIVPS26A [Mapview hg19]  VPS26A [Mapview hg38]
OMIM605506   
Gene and transcription
Genbank (Entrez)AF054179 AF175266 AK022992 AK290536 AK297142
RefSeq transcript (Entrez)NM_001035260 NM_001318944 NM_001318945 NM_001318946 NM_004896
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VPS26A
Cluster EST : UnigeneHs.499925 [ NCBI ]
CGAP (NCI)Hs.499925
Alternative Splicing GalleryENSG00000122958
Gene ExpressionVPS26A [ NCBI-GEO ]   VPS26A [ EBI - ARRAY_EXPRESS ]   VPS26A [ SEEK ]   VPS26A [ MEM ]
Gene Expression Viewer (FireBrowse)VPS26A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9559
GTEX Portal (Tissue expression)VPS26A
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75436   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75436  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75436
Splice isoforms : SwissVarO75436
PhosPhoSitePlusO75436
Domains : Interpro (EBI)Vps26-related   
Domain families : Pfam (Sanger)Vps26 (PF03643)   
Domain families : Pfam (NCBI)pfam03643   
Conserved Domain (NCBI)VPS26A
DMDM Disease mutations9559
Blocks (Seattle)VPS26A
PDB (SRS)2FAU    5F0J    5F0L    5F0M    5F0P   
PDB (PDBSum)2FAU    5F0J    5F0L    5F0M    5F0P   
PDB (IMB)2FAU    5F0J    5F0L    5F0M    5F0P   
PDB (RSDB)2FAU    5F0J    5F0L    5F0M    5F0P   
Structural Biology KnowledgeBase2FAU    5F0J    5F0L    5F0M    5F0P   
SCOP (Structural Classification of Proteins)2FAU    5F0J    5F0L    5F0M    5F0P   
CATH (Classification of proteins structures)2FAU    5F0J    5F0L    5F0M    5F0P   
SuperfamilyO75436
Human Protein AtlasENSG00000122958
Peptide AtlasO75436
HPRD08385
IPIIPI00411426   IPI01014262   IPI01013003   IPI00656002   
Protein Interaction databases
DIP (DOE-UCLA)O75436
IntAct (EBI)O75436
FunCoupENSG00000122958
BioGRIDVPS26A
STRING (EMBL)VPS26A
ZODIACVPS26A
Ontologies - Pathways
QuickGOO75436
Ontology : AmiGOprotein binding  lysosome  endosome  early endosome  cytosol  cytosol  intracellular protein transport  protein transporter activity  protein transporter activity  endosome membrane  Wnt signaling pathway  regulation of macroautophagy  retromer complex  retromer complex  retromer, cargo-selective complex  retromer, cargo-selective complex  vesicle  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  extracellular exosome  tubular endosome  retrograde transport, endosome to plasma membrane  
Ontology : EGO-EBIprotein binding  lysosome  endosome  early endosome  cytosol  cytosol  intracellular protein transport  protein transporter activity  protein transporter activity  endosome membrane  Wnt signaling pathway  regulation of macroautophagy  retromer complex  retromer complex  retromer, cargo-selective complex  retromer, cargo-selective complex  vesicle  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  extracellular exosome  tubular endosome  retrograde transport, endosome to plasma membrane  
NDEx NetworkVPS26A
Atlas of Cancer Signalling NetworkVPS26A
Wikipedia pathwaysVPS26A
Orthology - Evolution
OrthoDB9559
GeneTree (enSembl)ENSG00000122958
Phylogenetic Trees/Animal Genes : TreeFamVPS26A
HOVERGENO75436
HOGENOMO75436
Homologs : HomoloGeneVPS26A
Homology/Alignments : Family Browser (UCSC)VPS26A
Gene fusions - Rearrangements
Fusion: TCGATSPAN15 VPS26A
Fusion: TCGASUPV3L1 VPS26A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVPS26A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VPS26A
dbVarVPS26A
ClinVarVPS26A
1000_GenomesVPS26A 
Exome Variant ServerVPS26A
ExAC (Exome Aggregation Consortium)VPS26A (select the gene name)
Genetic variants : HAPMAP9559
Genomic Variants (DGV)VPS26A [DGVbeta]
DECIPHERVPS26A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVPS26A 
Mutations
ICGC Data PortalVPS26A 
TCGA Data PortalVPS26A 
Broad Tumor PortalVPS26A
OASIS PortalVPS26A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVPS26A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVPS26A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VPS26A
DgiDB (Drug Gene Interaction Database)VPS26A
DoCM (Curated mutations)VPS26A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VPS26A (select a term)
intoGenVPS26A
Cancer3DVPS26A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605506   
Orphanet
MedgenVPS26A
Genetic Testing Registry VPS26A
NextProtO75436 [Medical]
TSGene9559
GENETestsVPS26A
Target ValidationVPS26A
Huge Navigator VPS26A [HugePedia]
snp3D : Map Gene to Disease9559
BioCentury BCIQVPS26A
ClinGenVPS26A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9559
Chemical/Pharm GKB GenePA37326
Clinical trialVPS26A
Miscellaneous
canSAR (ICR)VPS26A (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVPS26A
EVEXVPS26A
GoPubMedVPS26A
iHOPVPS26A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:43:35 CEST 2017

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