VPS26A (VPS26, retromer complex component A)

2014-11-01  

Identity

HGNC
VPS26A
LOCATION
10q22.1
LOCUSID
9559
ALIAS
HB58,Hbeta58,PEP8A,VPS26
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9559
MIM: 605506
HGNC: 12711
Ensembl: ENSG00000122958

Variants:

dbSNP: 9559
ClinVar: 9559
TCGA: ENSG00000122958
COSMIC: VPS26A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122958ENST00000263559O75436
ENSG00000122958ENST00000373382O75436
ENSG00000122958ENST00000395098O75436
ENSG00000122958ENST00000489656S4R2Y3
ENSG00000122958ENST00000489794S4R3Q6

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195315832009Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.135
171017782007Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.81
251361262014A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.61
278892392016Structural Mechanism for Cargo Recognition by the Retromer Complex.44
219200052011Vps26A and Vps26B subunits define distinct retromer complexes.25
222840512012Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function.22
253931102014Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions.18
253673622015Molecular insights into Rab7-mediated endosomal recruitment of core retromer: deciphering the role of Vps26 and Vps35.17
254751422015Genetic variability of the retromer cargo recognition complex in parkinsonism.12
246847912014Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease.11

Citation

Dessen P

VPS26A (VPS26, retromer complex component A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75630/vps26a