Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

VPS33A (VPS33A core subunit of CORVET and HOPS complexes)

Identity

Alias (NCBI)MPSPS
HGNC (Hugo) VPS33A
HGNC Previous namevacuolar protein sorting 33A (yeast)
 vacuolar protein sorting 33 homolog A (S. cerevisiae)
 VPS33A, CORVET/HOPS core subunit
LocusID (NCBI) 65082
Atlas_Id 52644
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 122229564 and ends at 122266494 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
VPS33A (12q24.31) / MPHOSPH9 (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dup(12)(q24q24) VPS33A/MPHOSPH9


External links

Nomenclature
HGNC (Hugo)VPS33A   18179
Cards
Entrez_Gene (NCBI)VPS33A    VPS33A core subunit of CORVET and HOPS complexes
AliasesMPSPS
GeneCards (Weizmann)VPS33A
Ensembl hg19 (Hinxton)ENSG00000139719 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139719 [Gene_View]  ENSG00000139719 [Sequence]  chr12:122229564-122266494 [Contig_View]  VPS33A [Vega]
ICGC DataPortalENSG00000139719
TCGA cBioPortalVPS33A
AceView (NCBI)VPS33A
Genatlas (Paris)VPS33A
SOURCE (Princeton)VPS33A
Genetics Home Reference (NIH)VPS33A
Genomic and cartography
GoldenPath hg38 (UCSC)VPS33A  -     chr12:122229564-122266494 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VPS33A  -     12q24.31   [Description]    (hg19-Feb_2009)
GoldenPathVPS33A - 12q24.31 [CytoView hg19]  VPS33A - 12q24.31 [CytoView hg38]
ImmunoBaseENSG00000139719
genome Data Viewer NCBIVPS33A [Mapview hg19]  
OMIM610034   617303   
Gene and transcription
Genbank (Entrez)AF439857 AI830457 AK026048 AK026840 AK315545
RefSeq transcript (Entrez)NM_001351018 NM_001351019 NM_001351020 NM_001351021 NM_022916
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VPS33A
Alternative Splicing GalleryENSG00000139719
Gene ExpressionVPS33A [ NCBI-GEO ]   VPS33A [ EBI - ARRAY_EXPRESS ]   VPS33A [ SEEK ]   VPS33A [ MEM ]
Gene Expression Viewer (FireBrowse)VPS33A [ Firebrowse - Broad ]
GenevisibleExpression of VPS33A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)65082
GTEX Portal (Tissue expression)VPS33A
Human Protein AtlasENSG00000139719-VPS33A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96AX1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96AX1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96AX1
Splice isoforms : SwissVarQ96AX1
PhosPhoSitePlusQ96AX1
Domains : Interpro (EBI)Sec-1-like_dom1    Sec-1-like_dom2    Sec-1-like_dom3a    Sec1-like    Sec1-like_sf    VPS33    VPS33_dom3b   
Domain families : Pfam (Sanger)Sec1 (PF00995)   
Domain families : Pfam (NCBI)pfam00995   
Conserved Domain (NCBI)VPS33A
Blocks (Seattle)VPS33A
PDB (RSDB)4BX8    4BX9   
PDB Europe4BX8    4BX9   
PDB (PDBSum)4BX8    4BX9   
PDB (IMB)4BX8    4BX9   
Structural Biology KnowledgeBase4BX8    4BX9   
SCOP (Structural Classification of Proteins)4BX8    4BX9   
CATH (Classification of proteins structures)4BX8    4BX9   
SuperfamilyQ96AX1
Human Protein Atlas [tissue]ENSG00000139719-VPS33A [tissue]
Peptide AtlasQ96AX1
HPRD15651
IPIIPI00073179   IPI00795814   IPI01014453   IPI01014346   
Protein Interaction databases
DIP (DOE-UCLA)Q96AX1
IntAct (EBI)Q96AX1
BioGRIDVPS33A
STRING (EMBL)VPS33A
ZODIACVPS33A
Ontologies - Pathways
QuickGOQ96AX1
Ontology : AmiGOprotein binding  lysosome  lysosomal membrane  early endosome  late endosome  autophagosome  intracellular protein transport  vesicle docking involved in exocytosis  endosome to lysosome transport  vesicle-mediated transport  vesicle-mediated transport  AP-3 adaptor complex  clathrin-coated vesicle  platelet formation  HOPS complex  late endosome membrane  melanosome localization  lysosome localization  CORVET complex  regulation of lysosomal lumen pH  regulation of developmental pigmentation  perinuclear region of cytoplasm  clathrin complex  autophagosome maturation  
Ontology : EGO-EBIprotein binding  lysosome  lysosomal membrane  early endosome  late endosome  autophagosome  intracellular protein transport  vesicle docking involved in exocytosis  endosome to lysosome transport  vesicle-mediated transport  vesicle-mediated transport  AP-3 adaptor complex  clathrin-coated vesicle  platelet formation  HOPS complex  late endosome membrane  melanosome localization  lysosome localization  CORVET complex  regulation of lysosomal lumen pH  regulation of developmental pigmentation  perinuclear region of cytoplasm  clathrin complex  autophagosome maturation  
NDEx NetworkVPS33A
Atlas of Cancer Signalling NetworkVPS33A
Wikipedia pathwaysVPS33A
Orthology - Evolution
OrthoDB65082
GeneTree (enSembl)ENSG00000139719
Phylogenetic Trees/Animal Genes : TreeFamVPS33A
HOGENOMQ96AX1
Homologs : HomoloGeneVPS33A
Homology/Alignments : Family Browser (UCSC)VPS33A
Gene fusions - Rearrangements
Fusion : MitelmanVPS33A/MPHOSPH9 [12q24.31/12q24.31]  
Fusion : QuiverVPS33A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVPS33A [hg38]
dbVarVPS33A
ClinVarVPS33A
MonarchVPS33A
1000_GenomesVPS33A 
Exome Variant ServerVPS33A
GNOMAD BrowserENSG00000139719
Varsome BrowserVPS33A
Genomic Variants (DGV)VPS33A [DGVbeta]
DECIPHERVPS33A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVPS33A 
Mutations
ICGC Data PortalVPS33A 
TCGA Data PortalVPS33A 
Broad Tumor PortalVPS33A
OASIS PortalVPS33A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVPS33A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVPS33A
Mutations and Diseases : HGMDVPS33A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VPS33A
DgiDB (Drug Gene Interaction Database)VPS33A
DoCM (Curated mutations)VPS33A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VPS33A (select a term)
intoGenVPS33A
Cancer3DVPS33A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610034    617303   
Orphanet
DisGeNETVPS33A
MedgenVPS33A
Genetic Testing Registry VPS33A
NextProtQ96AX1 [Medical]
GENETestsVPS33A
Target ValidationVPS33A
Huge Navigator VPS33A [HugePedia]
ClinGenVPS33A
Clinical trials, drugs, therapy
MyCancerGenomeVPS33A
Protein Interactions : CTD
Pharm GKB GenePA38306
PharosQ96AX1
Clinical trialVPS33A
Miscellaneous
canSAR (ICR)VPS33A (select the gene name)
HarmonizomeVPS33A
DataMed IndexVPS33A
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXVPS33A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:52:41 CET 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.