Atlas of Genetics and Cytogenetics in Oncology and Haematology


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VPS36 (vacuolar protein sorting 36 homolog)

Identity

Alias (NCBI)C13orf9
CGI-145
EAP45
HGNC (Hugo) VPS36
HGNC Alias symbCGI-145
Eap45
HGNC Previous nameC13orf9
HGNC Previous namechromosome 13 open reading frame 9
 vacuolar protein sorting 36 homolog (yeast)
 vacuolar protein sorting 36 homolog (S. cerevisiae)
LocusID (NCBI) 51028
Atlas_Id 54767
Location 13q14.3  [Link to chromosome band 13q14]
Location_base_pair Starts at 52412606 and ends at 52450634 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC122 (13q14.11) / VPS36 (13q14.3)VPS36 (13q14.3) / PAIP2B (2p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(13)(q14q14) CCDC122/VPS36


External links

Nomenclature
HGNC (Hugo)VPS36   20312
Cards
Entrez_Gene (NCBI)VPS36    vacuolar protein sorting 36 homolog
AliasesC13orf9; CGI-145; EAP45
GeneCards (Weizmann)VPS36
Ensembl hg19 (Hinxton)ENSG00000136100 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136100 [Gene_View]  ENSG00000136100 [Sequence]  chr13:52412606-52450634 [Contig_View]  VPS36 [Vega]
ICGC DataPortalENSG00000136100
TCGA cBioPortalVPS36
AceView (NCBI)VPS36
Genatlas (Paris)VPS36
SOURCE (Princeton)VPS36
Genetics Home Reference (NIH)VPS36
Genomic and cartography
GoldenPath hg38 (UCSC)VPS36  -     chr13:52412606-52450634 -  13q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VPS36  -     13q14.3   [Description]    (hg19-Feb_2009)
GoldenPathVPS36 - 13q14.3 [CytoView hg19]  VPS36 - 13q14.3 [CytoView hg38]
ImmunoBaseENSG00000136100
genome Data Viewer NCBIVPS36 [Mapview hg19]  
OMIM610903   
Gene and transcription
Genbank (Entrez)AB208956 AF151903 AI221133 AI352102 AK022911
RefSeq transcript (Entrez)NM_001282168 NM_001282169 NM_016075
Consensus coding sequences : CCDS (NCBI)VPS36
Alternative Splicing GalleryENSG00000136100
Gene ExpressionVPS36 [ NCBI-GEO ]   VPS36 [ EBI - ARRAY_EXPRESS ]   VPS36 [ SEEK ]   VPS36 [ MEM ]
Gene Expression Viewer (FireBrowse)VPS36 [ Firebrowse - Broad ]
GenevisibleExpression of VPS36 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51028
GTEX Portal (Tissue expression)VPS36
Human Protein AtlasENSG00000136100-VPS36 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VN1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VN1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VN1
PhosPhoSitePlusQ86VN1
Domaine pattern : Prosite (Expaxy)GLUE (PS51495)   
Domains : Interpro (EBI)GLUE_dom    PH-like_dom_sf    Snf8/Vps36    Vps36    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)EAP30 (PF04157)    Vps36_ESCRT-II (PF11605)   
Domain families : Pfam (NCBI)pfam04157    pfam11605   
Conserved Domain (NCBI)VPS36
PDB (RSDB)2HTH    2ZME    3CUQ   
PDB Europe2HTH    2ZME    3CUQ   
PDB (PDBSum)2HTH    2ZME    3CUQ   
PDB (IMB)2HTH    2ZME    3CUQ   
Structural Biology KnowledgeBase2HTH    2ZME    3CUQ   
SCOP (Structural Classification of Proteins)2HTH    2ZME    3CUQ   
CATH (Classification of proteins structures)2HTH    2ZME    3CUQ   
SuperfamilyQ86VN1
AlphaFold pdb e-kbQ86VN1   
Human Protein Atlas [tissue]ENSG00000136100-VPS36 [tissue]
HPRD12620
Protein Interaction databases
DIP (DOE-UCLA)Q86VN1
IntAct (EBI)Q86VN1
BioGRIDVPS36
STRING (EMBL)VPS36
ZODIACVPS36
Ontologies - Pathways
QuickGOQ86VN1
Ontology : AmiGOESCRT II complex  ESCRT II complex  ESCRT II complex  protein binding  nucleus  endosome  cytosol  cytosol  protein C-terminus binding  endosomal transport  macroautophagy  late endosome membrane  late endosome membrane  phosphatidylinositol-3-phosphate binding  multivesicular body assembly  ubiquitin binding  ubiquitin binding  protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  extracellular exosome  
Ontology : EGO-EBIESCRT II complex  ESCRT II complex  ESCRT II complex  protein binding  nucleus  endosome  cytosol  cytosol  protein C-terminus binding  endosomal transport  macroautophagy  late endosome membrane  late endosome membrane  phosphatidylinositol-3-phosphate binding  multivesicular body assembly  ubiquitin binding  ubiquitin binding  protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  extracellular exosome  
Pathways : KEGGEndocytosis   
NDEx NetworkVPS36
Atlas of Cancer Signalling NetworkVPS36
Wikipedia pathwaysVPS36
Orthology - Evolution
OrthoDB51028
GeneTree (enSembl)ENSG00000136100
Phylogenetic Trees/Animal Genes : TreeFamVPS36
Homologs : HomoloGeneVPS36
Homology/Alignments : Family Browser (UCSC)VPS36
Gene fusions - Rearrangements
Fusion : MitelmanCCDC122/VPS36 [13q14.11/13q14.3]  
Fusion : QuiverVPS36
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVPS36 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VPS36
dbVarVPS36
ClinVarVPS36
MonarchVPS36
1000_GenomesVPS36 
Exome Variant ServerVPS36
GNOMAD BrowserENSG00000136100
Varsome BrowserVPS36
Genomic Variants (DGV)VPS36 [DGVbeta]
DECIPHERVPS36 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVPS36 
Mutations
ICGC Data PortalVPS36 
TCGA Data PortalVPS36 
Broad Tumor PortalVPS36
OASIS PortalVPS36 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVPS36  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVPS36
Mutations and Diseases : HGMDVPS36
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch VPS36
DgiDB (Drug Gene Interaction Database)VPS36
DoCM (Curated mutations)VPS36 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VPS36 (select a term)
Cancer3DVPS36(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610903   
Orphanet
DisGeNETVPS36
MedgenVPS36
Genetic Testing Registry VPS36
NextProtQ86VN1 [Medical]
GENETestsVPS36
Target ValidationVPS36
Huge Navigator VPS36 [HugePedia]
ClinGenVPS36
Clinical trials, drugs, therapy
MyCancerGenomeVPS36
Protein Interactions : CTDVPS36
Pharm GKB GenePA134990943
PharosQ86VN1
Clinical trialVPS36
Miscellaneous
canSAR (ICR)VPS36
HarmonizomeVPS36
DataMed IndexVPS36
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXVPS36
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:43:44 CEST 2021

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