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VPS37A (VPS37A, ESCRT-I subunit)

Identity

Other namesHCRP1
PQBP2
SPG53
HGNC (Hugo) VPS37A
LocusID (NCBI) 137492
Atlas_Id 40605
Location 8p22
Location_base_pair Starts at 17104401 and ends at 17155533 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MSANTD4 (11q22.3) / VPS37A (8p22)PDGFRL (8p22) / VPS37A (8p22)VPS37A (8p22) / SLC4A5 (2p13.1)
VPS37A (8p22) / VCAM1 (1p21.2)VPS37A (8p22) / VPS37A (8p22)PDGFRL 8p22 / VPS37A 8p22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)VPS37A   24928
Cards
Entrez_Gene (NCBI)VPS37A  137492  VPS37A, ESCRT-I subunit
AliasesHCRP1; PQBP2; SPG53
GeneCards (Weizmann)VPS37A
Ensembl hg19 (Hinxton)ENSG00000155975 [Gene_View]  chr8:17104401-17155533 [Contig_View]  VPS37A [Vega]
Ensembl hg38 (Hinxton)ENSG00000155975 [Gene_View]  chr8:17104401-17155533 [Contig_View]  VPS37A [Vega]
ICGC DataPortalENSG00000155975
TCGA cBioPortalVPS37A
AceView (NCBI)VPS37A
Genatlas (Paris)VPS37A
WikiGenes137492
SOURCE (Princeton)VPS37A
Genomic and cartography
GoldenPath hg19 (UCSC)VPS37A  -     chr8:17104401-17155533 +  8p22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)VPS37A  -     8p22   [Description]    (hg38-Dec_2013)
EnsemblVPS37A - 8p22 [CytoView hg19]  VPS37A - 8p22 [CytoView hg38]
Mapping of homologs : NCBIVPS37A [Mapview hg19]  VPS37A [Mapview hg38]
OMIM609927   614898   
Gene and transcription
Genbank (Entrez)AF547097 AK057204 AK090607 AK124607 AY033079
RefSeq transcript (Entrez)NM_001145152 NM_152415
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_032996 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)VPS37A
Cluster EST : UnigeneHs.343873 [ NCBI ]
CGAP (NCI)Hs.343873
Alternative Splicing GalleryENSG00000155975
Gene ExpressionVPS37A [ NCBI-GEO ]   VPS37A [ EBI - ARRAY_EXPRESS ]   VPS37A [ SEEK ]   VPS37A [ MEM ]
Gene Expression Viewer (FireBrowse)VPS37A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)137492
GTEX Portal (Tissue expression)VPS37A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NEZ2 (Uniprot)
NextProtQ8NEZ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NEZ2
Splice isoforms : SwissVarQ8NEZ2 (Swissvar)
PhosPhoSitePlusQ8NEZ2
Domaine pattern : Prosite (Expaxy)VPS37_C (PS51314)   
Domains : Interpro (EBI)Mod_r    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)Mod_r (PF07200)   
Domain families : Pfam (NCBI)pfam07200   
DMDM Disease mutations137492
Blocks (Seattle)VPS37A
SuperfamilyQ8NEZ2
Human Protein AtlasENSG00000155975
Peptide AtlasQ8NEZ2
HPRD13410
IPIIPI00302660   IPI00845460   IPI00166536   IPI00973879   IPI00974327   IPI00792298   IPI00973942   IPI00976087   
Protein Interaction databases
DIP (DOE-UCLA)Q8NEZ2
IntAct (EBI)Q8NEZ2
FunCoupENSG00000155975
BioGRIDVPS37A
STRING (EMBL)VPS37A
ZODIACVPS37A
Ontologies - Pathways
QuickGOQ8NEZ2
Ontology : AmiGOESCRT I complex  ESCRT I complex  protein binding  nucleoplasm  cytoplasm  centrosome  autophagy  endosome membrane  protein transport  endosomal transport  viral life cycle  late endosome membrane  multivesicular body assembly  viral budding via host ESCRT complex  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  intracellular membrane-bounded organelle  intracellular transport of virus  
Ontology : EGO-EBIESCRT I complex  ESCRT I complex  protein binding  nucleoplasm  cytoplasm  centrosome  autophagy  endosome membrane  protein transport  endosomal transport  viral life cycle  late endosome membrane  multivesicular body assembly  viral budding via host ESCRT complex  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  intracellular membrane-bounded organelle  intracellular transport of virus  
Pathways : KEGGEndocytosis   
NDEx Network
Atlas of Cancer Signalling NetworkVPS37A
Wikipedia pathwaysVPS37A
Orthology - Evolution
OrthoDB137492
GeneTree (enSembl)ENSG00000155975
Phylogenetic Trees/Animal Genes : TreeFamVPS37A
Homologs : HomoloGeneVPS37A
Homology/Alignments : Family Browser (UCSC)VPS37A
Gene fusions - Rearrangements
Fusion: TCGAPDGFRL 8p22 VPS37A 8p22 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerVPS37A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VPS37A
dbVarVPS37A
ClinVarVPS37A
1000_GenomesVPS37A 
Exome Variant ServerVPS37A
ExAC (Exome Aggregation Consortium)VPS37A (select the gene name)
Genetic variants : HAPMAP137492
Genomic Variants (DGV)VPS37A [DGVbeta]
Mutations
ICGC Data PortalVPS37A 
TCGA Data PortalVPS37A 
Broad Tumor PortalVPS37A
OASIS PortalVPS37A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVPS37A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VPS37A
DgiDB (Drug Gene Interaction Database)VPS37A
DoCM (Curated mutations)VPS37A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VPS37A (select a term)
intoGenVPS37A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:17104401-17155533  ENSG00000155975
CONAN: Copy Number AnalysisVPS37A 
Mutations and Diseases : HGMDVPS37A
OMIM609927    614898   
MedgenVPS37A
Genetic Testing Registry VPS37A
NextProtQ8NEZ2 [Medical]
TSGene137492
GENETestsVPS37A
Huge Navigator VPS37A [HugePedia]
snp3D : Map Gene to Disease137492
BioCentury BCIQVPS37A
ClinGenVPS37A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD137492
Chemical/Pharm GKB GenePA142670615
Clinical trialVPS37A
Miscellaneous
canSAR (ICR)VPS37A (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVPS37A
EVEXVPS37A
GoPubMedVPS37A
iHOPVPS37A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:27:15 CEST 2016

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