Atlas of Genetics and Cytogenetics in Oncology and Haematology


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VPS37C (VPS37C subunit of ESCRT-I)

Identity

Alias (NCBI)-
HGNC (Hugo) VPS37C
HGNC Alias symbFLJ20847
HGNC Previous namevacuolar protein sorting 37C (yeast)
 vacuolar protein sorting 37 homolog C (S. cerevisiae)
LocusID (NCBI) 55048
Atlas_Id 75635
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61130256 and ends at 61161444 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CMC1 (3p24.1) / VPS37C (11q12.2)LRP5 (11q13.2) / VPS37C (11q12.2)RNF121 (11q13.4) / VPS37C (11q12.2)
RP11-849H4.2 () / VPS37C (11q12.2)VPS37C (11q12.2) / SLC3A2 (11q12.3)ZDHHC21 (9p22.3) / VPS37C (11q12.2)
RNF121 VPS37CRP11-849H4.2 VPS37CCMC1 VPS37C
LRP5 VPS37C

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(3;11)(p24;q12) CMC1/VPS37C
VPS37C/SLC3A2 (11q12)
t(11;11)(q12;q13) LRP5/VPS37C
t(11;11)(q12;q13) RNF121/VPS37C


External links

Nomenclature
HGNC (Hugo)VPS37C   26097
Cards
Entrez_Gene (NCBI)VPS37C  55048  VPS37C subunit of ESCRT-I
Aliases
GeneCards (Weizmann)VPS37C
Ensembl hg19 (Hinxton)ENSG00000167987 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167987 [Gene_View]  ENSG00000167987 [Sequence]  chr11:61130256-61161444 [Contig_View]  VPS37C [Vega]
ICGC DataPortalENSG00000167987
TCGA cBioPortalVPS37C
AceView (NCBI)VPS37C
Genatlas (Paris)VPS37C
WikiGenes55048
SOURCE (Princeton)VPS37C
Genetics Home Reference (NIH)VPS37C
Genomic and cartography
GoldenPath hg38 (UCSC)VPS37C  -     chr11:61130256-61161444 -  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VPS37C  -     11q12.2   [Description]    (hg19-Feb_2009)
GoldenPathVPS37C - 11q12.2 [CytoView hg19]  VPS37C - 11q12.2 [CytoView hg38]
ImmunoBaseENSG00000167987
genome Data Viewer NCBIVPS37C [Mapview hg19]  
OMIM610038   
Gene and transcription
Genbank (Entrez)AK000854 AK097326 AK302384 AL834261 BC005805
RefSeq transcript (Entrez)NM_017966
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VPS37C
Alternative Splicing GalleryENSG00000167987
Gene ExpressionVPS37C [ NCBI-GEO ]   VPS37C [ EBI - ARRAY_EXPRESS ]   VPS37C [ SEEK ]   VPS37C [ MEM ]
Gene Expression Viewer (FireBrowse)VPS37C [ Firebrowse - Broad ]
GenevisibleExpression of VPS37C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55048
GTEX Portal (Tissue expression)VPS37C
Human Protein AtlasENSG00000167987-VPS37C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA5D8V6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA5D8V6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA5D8V6
Splice isoforms : SwissVarA5D8V6
PhosPhoSitePlusA5D8V6
Domaine pattern : Prosite (Expaxy)VPS37_C (PS51314)   
Domains : Interpro (EBI)ESCRT_assembly_dom    Mod_r    Vps37   
Domain families : Pfam (Sanger)Mod_r (PF07200)   
Domain families : Pfam (NCBI)pfam07200   
Conserved Domain (NCBI)VPS37C
DMDM Disease mutations55048
Blocks (Seattle)VPS37C
SuperfamilyA5D8V6
Human Protein Atlas [tissue]ENSG00000167987-VPS37C [tissue]
Peptide AtlasA5D8V6
HPRD15652
IPIIPI00401773   IPI01011695   IPI00305106   
Protein Interaction databases
DIP (DOE-UCLA)A5D8V6
IntAct (EBI)A5D8V6
FunCoupENSG00000167987
BioGRIDVPS37C
STRING (EMBL)VPS37C
ZODIACVPS37C
Ontologies - Pathways
QuickGOA5D8V6
Ontology : AmiGOESCRT I complex  ESCRT I complex  ESCRT I complex  protein binding  protein targeting to membrane  protein targeting to vacuole  endosome membrane  endosomal transport  macroautophagy  viral life cycle  late endosome membrane  endosome transport via multivesicular body sorting pathway  multivesicular body assembly  viral budding via host ESCRT complex  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  intracellular membrane-bounded organelle  host cell  calcium-dependent protein binding  extracellular exosome  intracellular transport of virus  
Ontology : EGO-EBIESCRT I complex  ESCRT I complex  ESCRT I complex  protein binding  protein targeting to membrane  protein targeting to vacuole  endosome membrane  endosomal transport  macroautophagy  viral life cycle  late endosome membrane  endosome transport via multivesicular body sorting pathway  multivesicular body assembly  viral budding via host ESCRT complex  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  intracellular membrane-bounded organelle  host cell  calcium-dependent protein binding  extracellular exosome  intracellular transport of virus  
NDEx NetworkVPS37C
Atlas of Cancer Signalling NetworkVPS37C
Wikipedia pathwaysVPS37C
Orthology - Evolution
OrthoDB55048
GeneTree (enSembl)ENSG00000167987
Phylogenetic Trees/Animal Genes : TreeFamVPS37C
HOGENOMA5D8V6
Homologs : HomoloGeneVPS37C
Homology/Alignments : Family Browser (UCSC)VPS37C
Gene fusions - Rearrangements
Fusion PortalRNF121 VPS37C
Fusion PortalRP11-849H4.2 VPS37C
Fusion PortalCMC1 VPS37C
Fusion PortalLRP5 VPS37C
Fusion : QuiverVPS37C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVPS37C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VPS37C
dbVarVPS37C
ClinVarVPS37C
1000_GenomesVPS37C 
Exome Variant ServerVPS37C
GNOMAD BrowserENSG00000167987
Varsome BrowserVPS37C
Genetic variants : HAPMAP55048
Genomic Variants (DGV)VPS37C [DGVbeta]
DECIPHERVPS37C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVPS37C 
Mutations
ICGC Data PortalVPS37C 
TCGA Data PortalVPS37C 
Broad Tumor PortalVPS37C
OASIS PortalVPS37C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVPS37C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVPS37C
Mutations and Diseases : HGMDVPS37C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VPS37C
DgiDB (Drug Gene Interaction Database)VPS37C
DoCM (Curated mutations)VPS37C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VPS37C (select a term)
intoGenVPS37C
Cancer3DVPS37C(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610038   
Orphanet
DisGeNETVPS37C
MedgenVPS37C
Genetic Testing Registry VPS37C
NextProtA5D8V6 [Medical]
TSGene55048
GENETestsVPS37C
Target ValidationVPS37C
Huge Navigator VPS37C [HugePedia]
snp3D : Map Gene to Disease55048
BioCentury BCIQVPS37C
ClinGenVPS37C
Clinical trials, drugs, therapy
Protein Interactions : CTD55048
Pharm GKB GenePA142670617
Clinical trialVPS37C
Miscellaneous
canSAR (ICR)VPS37C (select the gene name)
HarmonizomeVPS37C
DataMed IndexVPS37C
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVPS37C
EVEXVPS37C
GoPubMedVPS37C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 16:35:13 CEST 2020

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