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VPS41 (VPS41 subunit of HOPS complex)

Identity

Alias (NCBI)HVPS41
HVSP41
hVps41p
HGNC (Hugo) VPS41
HGNC Alias symbHVSP41
HGNC Previous namevacuolar protein sorting 41 (yeast homolog)
 vacuolar protein sorting 41 (yeast)
 vacuolar protein sorting 41 homolog (S. cerevisiae)
 VPS41, HOPS complex subunit
LocusID (NCBI) 27072
Atlas_Id 56533
Location 7p14.1  [Link to chromosome band 7p14]
Location_base_pair Starts at 38723943 and ends at 38909200 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KIAA1033 (12q23.3) / VPS41 (7p14.1)VPS41 (7p14.1) / AES (19p13.3)VPS41 (7p14.1) / KLF12 (13q22.1)
VPS41 (7p14.1) / NPSR1 (7p14.3)VPS41 (7p14.1) / SDK1 (7p22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)VPS41   12713
Cards
Entrez_Gene (NCBI)VPS41    VPS41 subunit of HOPS complex
AliasesHVPS41; HVSP41; hVps41p
GeneCards (Weizmann)VPS41
Ensembl hg19 (Hinxton)ENSG00000006715 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006715 [Gene_View]  ENSG00000006715 [Sequence]  chr7:38723943-38909200 [Contig_View]  VPS41 [Vega]
ICGC DataPortalENSG00000006715
TCGA cBioPortalVPS41
AceView (NCBI)VPS41
Genatlas (Paris)VPS41
SOURCE (Princeton)VPS41
Genetics Home Reference (NIH)VPS41
Genomic and cartography
GoldenPath hg38 (UCSC)VPS41  -     chr7:38723943-38909200 -  7p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VPS41  -     7p14.1   [Description]    (hg19-Feb_2009)
GoldenPathVPS41 - 7p14.1 [CytoView hg19]  VPS41 - 7p14.1 [CytoView hg38]
ImmunoBaseENSG00000006715
Genome Data Viewer NCBIVPS41 [Mapview hg19]  
OMIM605485   
Gene and transcription
Genbank (Entrez)AK026848 AK074325 AK299143 AK314556 BC044851
RefSeq transcript (Entrez)NM_014396 NM_080631
Consensus coding sequences : CCDS (NCBI)VPS41
Gene ExpressionVPS41 [ NCBI-GEO ]   VPS41 [ EBI - ARRAY_EXPRESS ]   VPS41 [ SEEK ]   VPS41 [ MEM ]
Gene Expression Viewer (FireBrowse)VPS41 [ Firebrowse - Broad ]
GenevisibleExpression of VPS41 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27072
GTEX Portal (Tissue expression)VPS41
Human Protein AtlasENSG00000006715-VPS41 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49754   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49754  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49754
PhosPhoSitePlusP49754
Domaine pattern : Prosite (Expaxy)CHCR (PS50236)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Clathrin_H-chain/VPS_repeat    TPR-like_helical_dom_sf    VPS41    WD40/YVTN_repeat-like_dom_sf    WD40_repeat_dom_sf    Znf_RING   
Domain families : Pfam (Sanger)Clathrin (PF00637)   
Domain families : Pfam (NCBI)pfam00637   
Domain families : Smart (EMBL)CLH (SM00299)  
Conserved Domain (NCBI)VPS41
SuperfamilyP49754
AlphaFold pdb e-kbP49754   
Human Protein Atlas [tissue]ENSG00000006715-VPS41 [tissue]
HPRD10402
Protein Interaction databases
DIP (DOE-UCLA)P49754
IntAct (EBI)P49754
BioGRIDVPS41
STRING (EMBL)VPS41
ZODIACVPS41
Ontologies - Pathways
QuickGOP49754
Ontology : AmiGOprotein binding  lysosome  lysosomal membrane  lysosomal membrane  early endosome  late endosome  late endosome  Golgi apparatus  Golgi-associated vesicle  protein targeting to vacuole  microtubule binding  endosome to lysosome transport  cellular response to starvation  endosome membrane  microtubule cytoskeleton  macroautophagy  clathrin-coated vesicle  HOPS complex  HOPS complex  late endosome membrane  endosomal vesicle fusion  endosomal vesicle fusion  identical protein binding  protein self-association  regulated exocytosis  metal ion binding  lysosomal HOPS complex  late endosome to lysosome transport  
Ontology : EGO-EBIprotein binding  lysosome  lysosomal membrane  lysosomal membrane  early endosome  late endosome  late endosome  Golgi apparatus  Golgi-associated vesicle  protein targeting to vacuole  microtubule binding  endosome to lysosome transport  cellular response to starvation  endosome membrane  microtubule cytoskeleton  macroautophagy  clathrin-coated vesicle  HOPS complex  HOPS complex  late endosome membrane  endosomal vesicle fusion  endosomal vesicle fusion  identical protein binding  protein self-association  regulated exocytosis  metal ion binding  lysosomal HOPS complex  late endosome to lysosome transport  
NDEx NetworkVPS41
Atlas of Cancer Signalling NetworkVPS41
Wikipedia pathwaysVPS41
Orthology - Evolution
OrthoDB27072
GeneTree (enSembl)ENSG00000006715
Phylogenetic Trees/Animal Genes : TreeFamVPS41
Homologs : HomoloGeneVPS41
Homology/Alignments : Family Browser (UCSC)VPS41
Gene fusions - Rearrangements
Fusion : QuiverVPS41
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVPS41 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VPS41
dbVarVPS41
ClinVarVPS41
MonarchVPS41
1000_GenomesVPS41 
Exome Variant ServerVPS41
GNOMAD BrowserENSG00000006715
Varsome BrowserVPS41
ACMGVPS41 variants
VarityP49754
Genomic Variants (DGV)VPS41 [DGVbeta]
DECIPHERVPS41 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVPS41 
Mutations
ICGC Data PortalVPS41 
TCGA Data PortalVPS41 
Broad Tumor PortalVPS41
OASIS PortalVPS41 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVPS41  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVPS41
Mutations and Diseases : HGMDVPS41
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaVPS41
DgiDB (Drug Gene Interaction Database)VPS41
DoCM (Curated mutations)VPS41
CIViC (Clinical Interpretations of Variants in Cancer)VPS41
Cancer3DVPS41
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605485   
Orphanet
DisGeNETVPS41
MedgenVPS41
Genetic Testing Registry VPS41
NextProtP49754 [Medical]
GENETestsVPS41
Target ValidationVPS41
Huge Navigator VPS41 [HugePedia]
ClinGenVPS41
Clinical trials, drugs, therapy
MyCancerGenomeVPS41
Protein Interactions : CTDVPS41
Pharm GKB GenePA37328
PharosP49754
Clinical trialVPS41
Miscellaneous
canSAR (ICR)VPS41
HarmonizomeVPS41
DataMed IndexVPS41
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXVPS41
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:38:06 CEST 2021

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