VPS4B (vacuolar protein sorting 4 homolog B)

2012-04-01  

Identity

HGNC
LOCATION
18q21.33
LOCUSID
ALIAS
MIG1,SKD1,SKD1B,VPS4-2
FUSION GENES

Other Information

Locus ID:

NCBI: 9525
MIM: 609983
HGNC: 10895
Ensembl: ENSG00000119541

Variants:

dbSNP: 9525
ClinVar: 9525
TCGA: ENSG00000119541
COSMIC: VPS4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119541ENST00000238497O75351
ENSG00000119541ENST00000238497A0A024R2C5
ENSG00000119541ENST00000588059K7EL71
ENSG00000119541ENST00000591519K7EKZ3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
179288622007ESCRT-III recognition by VPS4 ATPases.153
161930692005Structural and mechanistic studies of VPS4 proteins.105
206160622010Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.82
175538702007Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin.62
255343482014Mechanism of Ca²⁺-triggered ESCRT assembly and regulation of cell membrane repair.59
195249962009Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway.33
170146992006Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function.32
160046032005The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B.20
187960092008Nucleotide-dependent conformational changes and assembly of the AAA ATPase SKD1/VPS4B.18
256570072015Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains.16

Citation

Dessen P

VPS4B (vacuolar protein sorting 4 homolog B)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52680/vps4b