VPS52 (VPS52 subunit of GARP complex)

2018-07-01  

Identity

HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
ARE1,SAC2,SACM2L,dJ1033B10.5
FUSION GENES

Other Information

Locus ID:

NCBI: 6293
MIM: 603443
HGNC: 10518
Ensembl: ENSG00000223501

Variants:

dbSNP: 6293
ClinVar: 6293
TCGA: ENSG00000223501
COSMIC: VPS52

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000223501ENST00000445902Q8N1B4
ENSG00000223501ENST00000445902Q4VXZ2
ENSG00000223501ENST00000482399E9PI03

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183675452008Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.62
196202882009Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.53
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
158783292005Characterization of the human GARP (Golgi associated retrograde protein) complex.45
252694722014p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system.22
278896392017Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.13
122104842002Linkage between polymorphisms in the prostate specific antigen ARE1 gene region, prostate cancer risk, and circulating tumor cells.7
123667832002Susceptibility locus for non-obstructive azoospermia is localized within the HLA-DR/DQ subregion: primary role of DQB1*0604.6
315339532019The PI(4)P phosphatase Sac2 controls insulin granule docking and release.3
287914382017VPS52 induces apoptosis via cathepsin D in gastric cancer.2

Citation

Dessen P

VPS52 (VPS52 subunit of GARP complex)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57433/vps52