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VRK2 (vaccinia related kinase 2)

Identity

Other names-
HGNC (Hugo) VRK2
Location 2p16.1
Location_base_pair Starts at 58127233 and ends at 58240559 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)VRK2   12719
Entrez_Gene (NCBI)VRK2  7444  vaccinia related kinase 2
Cards
GeneCards (Weizmann)VRK2
Ensembl (Hinxton)ENSG00000028116 [Gene_View]  VRK2 [Vega]
AceView (NCBI)VRK2
Genatlas (Paris)VRK2
euGene (Indiana)7444
SOURCE (Stanford)NM_001130480 NM_001130481 NM_001130482 NM_001130483 NM_001136027 NM_006296
Gene Expression (Array Express) ENSG00000028116
Genomic and cartography
GoldenPath (UCSC)VRK2  -  2p16.1   chr2:58127233-58240559 +  2p16.1   [Description]    (hg18-March_2006)
EnsemblVRK2 - 2p16.1 [CytoView]
Mapping of homologs : NCBIVRK2 [Mapview]
OMIM602169   
Gene and transcription
Gene : Genbank (Entrez)AB000450 AJ512204 AK058199 AK223540 AK295193
Reference sequence (RefSeq transcript) :SRSNM_001130480 NM_001130481 NM_001130482 NM_001130483 NM_001136027 NM_006296
Reference transcript : EntrezNM_001130480 NM_001130481 NM_001130482 NM_001130483 NM_001136027 NM_006296
RefSeq genomic : SRSAC_000045 AC_000134 NC_000002 NT_022184 NW_001838769 NW_927719
RefSeq genomic : EntrezAC_000045 AC_000134 NC_000002 NT_022184 NW_001838769 NW_927719
Consensus coding sequences : CCDS NCBIVRK2
Cluster EST : UnigeneHs.631890 [ SRS ] Hs.631890 [ NCBI ]
Alternative Splicing : Fast-db (Paris)5482
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ86Y07 (SRS) Q86Y07 (Expasy) Q86Y07 (Uniprot)
With graphics : InterProQ86Y07
Splice isoforms : VarSplice FASTAQ86Y07(VarSplice FASTA)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domain pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Se/Thr_prot_kinase-like_dom    Ser/Thr_prot_kinase_AS   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Se/Thr_prot_kinase-like_dom    Ser/Thr_prot_kinase_AS   
Related proteins : CluSTrQ86Y07
Domain families : Pfam SRSPkinase (PF00069)   
Domain families : Pfam SangerPkinase (PF00069)   
Domain families : Pfam NCBIpfam00069   
Blocks (Seattle)Q86Y07
Crystal structure of protein : PDB SRS2V62   
Crystal structure of protein : PDBSum2V62   
Crystal structure of protein : IMB2V62   
Crystal structure of protein : PDB RSDB2V62   
HPRD03702
Protein Interaction databases
DIP (DOE-UCLA)Q86Y07
IntAct (EBI)Q86Y07
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIVRK2
SNP : GeneSNP UtahVRK2
SNP : HGBaseVRK2
Genetic variants : HAPMAPVRK2
Somatic Mutations in Cancer : COSMICVRK2 
Mutations and Diseases : HGMDVRK2
Hereditary diseases : OMIM602169   
Hereditary diseases : GENETests602169   
Diseases : Genetic AssociationVRK2
General knowledge
Homologs : HomoloGeneVRK2
Homology/Alignments : Family Browser UCSCVRK2
Phylogenetic Trees/Animal Genes : TreeFamVRK2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Chemical/Protein Interactions : CTD7444
Keywords Ontology : AmiGOnucleotide binding  protein serine/threonine kinase activity  protein binding  ATP binding  membrane fraction  endoplasmic reticulum  membrane  integral to membrane  transferase activity  protein amino acid autophosphorylation  
Keywords Ontology : EGO-EBInucleotide binding  protein serine/threonine kinase activity  protein binding  ATP binding  membrane fraction  endoplasmic reticulum  membrane  integral to membrane  transferase activity  protein amino acid autophosphorylation  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesVRK2 Related clones (RZPD - Berlin)
Literature
PubMed14 Pubmed reference(s) in Entrez
PubGeneVRK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:30:06 CET 2010
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