Atlas of Genetics and Cytogenetics in Oncology and Haematology

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VRK3 (vaccinia related kinase 3)

Identity

Other alias-
HGNC (Hugo) VRK3
LocusID (NCBI) 51231
Atlas_Id 43075
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49976467 and ends at 50025548 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP35 (19q13.32) / VRK3 (19q13.33)PSAP (10q22.1) / VRK3 (19q13.33)VRK3 (19q13.33) / VRK3 (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)VRK3   18996
Cards
Entrez_Gene (NCBI)VRK3  51231  vaccinia related kinase 3
Aliases
GeneCards (Weizmann)VRK3
Ensembl hg19 (Hinxton)ENSG00000105053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105053 [Gene_View]  ENSG00000105053 [Sequence]  chr19:49976467-50025548 [Contig_View]  VRK3 [Vega]
ICGC DataPortalENSG00000105053
TCGA cBioPortalVRK3
AceView (NCBI)VRK3
Genatlas (Paris)VRK3
WikiGenes51231
SOURCE (Princeton)VRK3
Genetics Home Reference (NIH)VRK3
Genomic and cartography
GoldenPath hg38 (UCSC)VRK3  -     chr19:49976467-50025548 -  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VRK3  -     19q13.33   [Description]    (hg19-Feb_2009)
EnsemblVRK3 - 19q13.33 [CytoView hg19]  VRK3 - 19q13.33 [CytoView hg38]
Mapping of homologs : NCBIVRK3 [Mapview hg19]  VRK3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB031052 AF514788 AK074461 AK123892 AK125747
RefSeq transcript (Entrez)NM_001025778 NM_001308420 NM_016440
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VRK3
Cluster EST : UnigeneHs.443330 [ NCBI ]
CGAP (NCI)Hs.443330
Alternative Splicing GalleryENSG00000105053
Gene ExpressionVRK3 [ NCBI-GEO ]   VRK3 [ EBI - ARRAY_EXPRESS ]   VRK3 [ SEEK ]   VRK3 [ MEM ]
Gene Expression Viewer (FireBrowse)VRK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51231
GTEX Portal (Tissue expression)VRK3
Human Protein AtlasENSG00000105053-VRK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IV63   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IV63  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IV63
Splice isoforms : SwissVarQ8IV63
PhosPhoSitePlusQ8IV63
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Zinc_ribbon_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)    zinc_ribbon_2 (PF13240)   
Domain families : Pfam (NCBI)pfam00069    pfam13240   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)VRK3
DMDM Disease mutations51231
Blocks (Seattle)VRK3
PDB (SRS)2JII   
PDB (PDBSum)2JII   
PDB (IMB)2JII   
PDB (RSDB)2JII   
Structural Biology KnowledgeBase2JII   
SCOP (Structural Classification of Proteins)2JII   
CATH (Classification of proteins structures)2JII   
SuperfamilyQ8IV63
Human Protein Atlas [tissue]ENSG00000105053-VRK3 [tissue]
Peptide AtlasQ8IV63
HPRD18289
IPIIPI00009291   IPI00375335   IPI00910163   IPI00910366   IPI00641769   
Protein Interaction databases
DIP (DOE-UCLA)Q8IV63
IntAct (EBI)Q8IV63
FunCoupENSG00000105053
BioGRIDVRK3
STRING (EMBL)VRK3
ZODIACVRK3
Ontologies - Pathways
QuickGOQ8IV63
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  nucleolus  cytoplasm  peptidyl-serine phosphorylation  protein phosphatase binding  positive regulation of phosphoprotein phosphatase activity  intracellular membrane-bounded organelle  negative regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  nucleolus  cytoplasm  peptidyl-serine phosphorylation  protein phosphatase binding  positive regulation of phosphoprotein phosphatase activity  intracellular membrane-bounded organelle  negative regulation of ERK1 and ERK2 cascade  
NDEx NetworkVRK3
Atlas of Cancer Signalling NetworkVRK3
Wikipedia pathwaysVRK3
Orthology - Evolution
OrthoDB51231
GeneTree (enSembl)ENSG00000105053
Phylogenetic Trees/Animal Genes : TreeFamVRK3
HOVERGENQ8IV63
HOGENOMQ8IV63
Homologs : HomoloGeneVRK3
Homology/Alignments : Family Browser (UCSC)VRK3
Gene fusions - Rearrangements
Fusion : QuiverVRK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVRK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VRK3
dbVarVRK3
ClinVarVRK3
1000_GenomesVRK3 
Exome Variant ServerVRK3
ExAC (Exome Aggregation Consortium)ENSG00000105053
GNOMAD BrowserENSG00000105053
Varsome BrowserVRK3
Genetic variants : HAPMAP51231
Genomic Variants (DGV)VRK3 [DGVbeta]
DECIPHERVRK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVRK3 
Mutations
ICGC Data PortalVRK3 
TCGA Data PortalVRK3 
Broad Tumor PortalVRK3
OASIS PortalVRK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVRK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVRK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VRK3
DgiDB (Drug Gene Interaction Database)VRK3
DoCM (Curated mutations)VRK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VRK3 (select a term)
intoGenVRK3
Cancer3DVRK3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETVRK3
MedgenVRK3
Genetic Testing Registry VRK3
NextProtQ8IV63 [Medical]
TSGene51231
GENETestsVRK3
Target ValidationVRK3
Huge Navigator VRK3 [HugePedia]
snp3D : Map Gene to Disease51231
BioCentury BCIQVRK3
ClinGenVRK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51231
Chemical/Pharm GKB GenePA134923990
Clinical trialVRK3
Miscellaneous
canSAR (ICR)VRK3 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVRK3
EVEXVRK3
GoPubMedVRK3
iHOPVRK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 12:01:32 CEST 2018
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