Atlas of Genetics and Cytogenetics in Oncology and Haematology

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VRK3 (VRK serine/threonine kinase 3)

Identity

Alias (NCBI)-
HGNC (Hugo) VRK3
HGNC Previous namevaccinia related kinase 3
LocusID (NCBI) 51231
Atlas_Id 43075
Location 19q13.33  [Link to chromosome band 19q13]
Location_base_pair Starts at 49976468 and ends at 50025372 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP35 (19q13.32)::VRK3 (19q13.33)PSAP (10q22.1)::VRK3 (19q13.33)VRK3 (19q13.33)::VRK3 (19q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)VRK3   18996
Cards
Entrez_Gene (NCBI)VRK3    VRK serine/threonine kinase 3
Aliases
GeneCards (Weizmann)VRK3
Ensembl hg19 (Hinxton)ENSG00000105053 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105053 [Gene_View]  ENSG00000105053 [Sequence]  chr19:49976468-50025372 [Contig_View]  VRK3 [Vega]
ICGC DataPortalENSG00000105053
TCGA cBioPortalVRK3
AceView (NCBI)VRK3
Genatlas (Paris)VRK3
SOURCE (Princeton)VRK3
Genetics Home Reference (NIH)VRK3
Genomic and cartography
GoldenPath hg38 (UCSC)VRK3  -     chr19:49976468-50025372 -  19q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VRK3  -     19q13.33   [Description]    (hg19-Feb_2009)
GoldenPathVRK3 - 19q13.33 [CytoView hg19]  VRK3 - 19q13.33 [CytoView hg38]
ImmunoBaseENSG00000105053
Genome Data Viewer NCBIVRK3 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB031052 AF514788 AK074461 AK123892 AK125747
RefSeq transcript (Entrez)NM_001025778 NM_001308420 NM_016440
Consensus coding sequences : CCDS (NCBI)VRK3
Gene ExpressionVRK3 [ NCBI-GEO ]   VRK3 [ EBI - ARRAY_EXPRESS ]   VRK3 [ SEEK ]   VRK3 [ MEM ]
Gene Expression Viewer (FireBrowse)VRK3 [ Firebrowse - Broad ]
GenevisibleExpression of VRK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51231
GTEX Portal (Tissue expression)VRK3
Human Protein AtlasENSG00000105053-VRK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IV63   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IV63  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IV63
PhosPhoSitePlusQ8IV63
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Zinc_ribbon_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)    zinc_ribbon_2 (PF13240)   
Domain families : Pfam (NCBI)pfam00069    pfam13240   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)VRK3
PDB (RSDB)2JII   
PDB Europe2JII   
PDB (PDBSum)2JII   
PDB (IMB)2JII   
Structural Biology KnowledgeBase2JII   
SCOP (Structural Classification of Proteins)2JII   
CATH (Classification of proteins structures)2JII   
SuperfamilyQ8IV63
AlphaFold pdb e-kbQ8IV63   
Human Protein Atlas [tissue]ENSG00000105053-VRK3 [tissue]
HPRD18289
Protein Interaction databases
DIP (DOE-UCLA)Q8IV63
IntAct (EBI)Q8IV63
BioGRIDVRK3
STRING (EMBL)VRK3
ZODIACVRK3
Ontologies - Pathways
QuickGOQ8IV63
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  signal transduction  histone phosphorylation  peptidyl-serine phosphorylation  protein phosphatase binding  positive regulation of phosphoprotein phosphatase activity  intracellular membrane-bounded organelle  negative regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  signal transduction  histone phosphorylation  peptidyl-serine phosphorylation  protein phosphatase binding  positive regulation of phosphoprotein phosphatase activity  intracellular membrane-bounded organelle  negative regulation of ERK1 and ERK2 cascade  
NDEx NetworkVRK3
Atlas of Cancer Signalling NetworkVRK3
Wikipedia pathwaysVRK3
Orthology - Evolution
OrthoDB51231
GeneTree (enSembl)ENSG00000105053
Phylogenetic Trees/Animal Genes : TreeFamVRK3
Homologs : HomoloGeneVRK3
Homology/Alignments : Family Browser (UCSC)VRK3
Gene fusions - Rearrangements
Fusion : QuiverVRK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVRK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VRK3
dbVarVRK3
ClinVarVRK3
MonarchVRK3
1000_GenomesVRK3 
Exome Variant ServerVRK3
GNOMAD BrowserENSG00000105053
Varsome BrowserVRK3
ACMGVRK3 variants
VarityQ8IV63
Genomic Variants (DGV)VRK3 [DGVbeta]
DECIPHERVRK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVRK3 
Mutations
ICGC Data PortalVRK3 
TCGA Data PortalVRK3 
Broad Tumor PortalVRK3
OASIS PortalVRK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVRK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVRK3
Mutations and Diseases : HGMDVRK3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaVRK3
DgiDB (Drug Gene Interaction Database)VRK3
DoCM (Curated mutations)VRK3
CIViC (Clinical Interpretations of Variants in Cancer)VRK3
Cancer3DVRK3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETVRK3
MedgenVRK3
Genetic Testing Registry VRK3
NextProtQ8IV63 [Medical]
GENETestsVRK3
Target ValidationVRK3
Huge Navigator VRK3 [HugePedia]
ClinGenVRK3
Clinical trials, drugs, therapy
MyCancerGenomeVRK3
Protein Interactions : CTDVRK3
Pharm GKB GenePA134923990
PharosQ8IV63
Clinical trialVRK3
Miscellaneous
canSAR (ICR)VRK3
HarmonizomeVRK3
ARCHS4VRK3
DataMed IndexVRK3
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXVRK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:06:17 CET 2022
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