VSIR (V-set immunoregulatory receptor)

2016-12-01  

Identity

HGNC
VSIR
LOCATION
10q22.1
LOCUSID
64115
ALIAS
B7-H5,B7H5,C10orf54,DD1alpha,Dies1,GI24,PD-1H,PP2135,SISP1,VISTA

Other Information

Locus ID:

NCBI: 64115
MIM: 615608
HGNC: 30085
Ensembl: ENSG00000107738

Variants:

dbSNP: 64115
ClinVar: 64115
TCGA: ENSG00000107738
COSMIC: VSIR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107738ENST00000394957Q9H7M9

Expression (GTEx)

0
100
200
300
400
500
600
700
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
262281592015Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.64
282586942017Immunoregulatory functions of VISTA.36
306354252019Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer.25
282361182017Expression of VISTA correlated with immunosuppression and synergized with CD8 to predict survival in human oral squamous cell carcinoma.24
292035882018Spatially Resolved and Quantitative Analysis of VISTA/PD-1H as a Novel Immunotherapy Target in Human Non-Small Cell Lung Cancer.21
287765782017Negative immune checkpoint regulation by VISTA: a mechanism of acquired resistance to anti-PD-1 therapy in metastatic melanoma patients.19
302200832019VSIG-3 as a ligand of VISTA inhibits human T-cell function.19
206667772010GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.17
252799552014Characterization of programmed death-1 homologue-1 (PD-1H) expression and function in normal and HIV infected individuals.17
297201162018VISTA expression associated with CD8 confers a favorable immune microenvironment and better overall survival in hepatocellular carcinoma.15

Citation

Dessen P

VSIR (V-set immunoregulatory receptor)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56664/vsir