VTA1 (vesicle trafficking 1)

2014-11-01  

Identity

HGNC
LOCATION
6q24.1
LOCUSID
ALIAS
6orf55,C6orf55,DRG-1,DRG1,HSPC228,LIP5,My012,SBP1
FUSION GENES

Other Information

Locus ID:

NCBI: 51534
MIM: 610902
HGNC: 20954
Ensembl: ENSG00000009844

Variants:

dbSNP: 51534
ClinVar: 51534
TCGA: ENSG00000009844
COSMIC: VTA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000009844ENST00000367621Q5TGM0
ENSG00000009844ENST00000367630Q9NP79
ENSG00000009844ENST00000452973Q9NP79
ENSG00000009844ENST00000620996A0A087WY55

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
210608632010Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.57
231051062012Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport.25
256570072015Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains.16
256376302015A novel mechanism of regulating the ATPase VPS4 by its cofactor LIP5 and the endosomal sorting complex required for transport (ESCRT)-III protein CHMP5.14
251648172014Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 α7 and α9 to stimulate ATP hydrolysis.11
287102782017Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5.4
203582642010The lysosomal trafficking regulator interacting protein-5 localizes mainly in epithelial cells.2
316617932019Structural Insights into AQP2 Targeting to Multivesicular Bodies.0

Citation

Dessen P

VTA1 (vesicle trafficking 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75657/vta1