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VTI1A (vesicle transport through interaction with t-SNAREs 1A)

Identity

Alias_namesvesicle transport through interaction with t-SNAREs homolog 1A (yeast)
Alias_symbol (synonym)MVti1
Vti1a
Vti1-rp2
Other aliasMMDS3
VTI1RP2
HGNC (Hugo) VTI1A
LocusID (NCBI) 143187
Atlas_Id 52508
Location 10q25.2  [Link to chromosome band 10q25]
Location_base_pair Starts at 112446988 and ends at 112818744 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C1orf95 (1q42.12) / VTI1A (10q25.2)FAM160B1 (10q25.3) / VTI1A (10q25.2)NARS2 (11q14.1) / VTI1A (10q25.2)
TCF7L2 (10q25.2) / VTI1A (10q25.2)UXS1 (2q12.2) / VTI1A (10q25.2)VTI1A (10q25.2) / C10orf90 (10q26.2)
VTI1A (10q25.2) / SUGP2 (19p13.11)VTI1A (10q25.2) / TCF7L2 (10q25.2)VTI1A (10q25.2) / UBE2D1 (10q21.1)
VTI1A 10q25.2 / TCF7L2 10q25.2C1orf95 1q42.12 / VTI1A 10q25.2FAM160B1 10q25.3 / VTI1A 10q25.2
VTI1A 10q25.2 / C10orf90 10q26.2VTI1A 10q25.2 / SUGP2 19p13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]

Solid Tumors TT_del10q25q25ID100007 TT_t1010q25q25ID100276 TT_t1010q25q26ID100288 TT_t1019q25p13ID100425

External links

Nomenclature
HGNC (Hugo)VTI1A   17792
Cards
Entrez_Gene (NCBI)VTI1A  143187  vesicle transport through interaction with t-SNAREs 1A
AliasesMMDS3; MVti1; VTI1RP2; Vti1-rp2
GeneCards (Weizmann)VTI1A
Ensembl hg19 (Hinxton)ENSG00000151532 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151532 [Gene_View]  ENSG00000151532 [Sequence]  chr10:112446988-112818744 [Contig_View]  VTI1A [Vega]
ICGC DataPortalENSG00000151532
TCGA cBioPortalVTI1A
AceView (NCBI)VTI1A
Genatlas (Paris)VTI1A
WikiGenes143187
SOURCE (Princeton)VTI1A
Genetics Home Reference (NIH)VTI1A
Genomic and cartography
GoldenPath hg38 (UCSC)VTI1A  -     chr10:112446988-112818744 +  10q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VTI1A  -     10q25.2   [Description]    (hg19-Feb_2009)
GoldenPathVTI1A - 10q25.2 [CytoView hg19]  VTI1A - 10q25.2 [CytoView hg38]
ImmunoBaseENSG00000151532
Mapping of homologs : NCBIVTI1A [Mapview hg19]  VTI1A [Mapview hg38]
OMIM614316   
Gene and transcription
Genbank (Entrez)AI610960 AI693064 AI797732 AK026759 AK074471
RefSeq transcript (Entrez)NM_001318203 NM_001318205 NM_001365710 NM_001365711 NM_001365712 NM_001365713 NM_001365714 NM_145206
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VTI1A
Cluster EST : UnigeneHs.742069 [ NCBI ]
CGAP (NCI)Hs.742069
Alternative Splicing GalleryENSG00000151532
Gene ExpressionVTI1A [ NCBI-GEO ]   VTI1A [ EBI - ARRAY_EXPRESS ]   VTI1A [ SEEK ]   VTI1A [ MEM ]
Gene Expression Viewer (FireBrowse)VTI1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143187
GTEX Portal (Tissue expression)VTI1A
Human Protein AtlasENSG00000151532-VTI1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96AJ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96AJ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96AJ9
Splice isoforms : SwissVarQ96AJ9
PhosPhoSitePlusQ96AJ9
Domains : Interpro (EBI)GOSR2/Membrin/Bos1    SNARE    T_SNARE_dom    v-SNARE_N_sf    Vesicle_trsprt_v-SNARE_N   
Domain families : Pfam (Sanger)V-SNARE (PF05008)   
Domain families : Pfam (NCBI)pfam05008   
Domain families : Smart (EMBL)t_SNARE (SM00397)  
Conserved Domain (NCBI)VTI1A
DMDM Disease mutations143187
Blocks (Seattle)VTI1A
SuperfamilyQ96AJ9
Human Protein Atlas [tissue]ENSG00000151532-VTI1A [tissue]
Peptide AtlasQ96AJ9
HPRD18290
IPIIPI00059472   IPI00852968   
Protein Interaction databases
DIP (DOE-UCLA)Q96AJ9
IntAct (EBI)Q96AJ9
FunCoupENSG00000151532
BioGRIDVTI1A
STRING (EMBL)VTI1A
ZODIACVTI1A
Ontologies - Pathways
QuickGOQ96AJ9
Ontology : AmiGOGolgi membrane  SNARE binding  SNAP receptor activity  SNAP receptor activity  protein binding  endosome  autophagosome  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  cytosol  protein targeting to vacuole  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  intra-Golgi vesicle-mediated transport  Golgi to vacuole transport  autophagy  synaptic vesicle  ER to Golgi transport vesicle membrane  integral component of membrane  clathrin-coated vesicle  SNARE complex  SNARE complex  SNARE complex  late endosome membrane  trans-Golgi network membrane  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  neuronal cell body  intracellular membrane-bounded organelle  neuron projection terminus  vesicle fusion with Golgi apparatus  vesicle fusion with Golgi apparatus  perinuclear region of cytoplasm  voluntary musculoskeletal movement  Golgi ribbon formation  
Ontology : EGO-EBIGolgi membrane  SNARE binding  SNAP receptor activity  SNAP receptor activity  protein binding  endosome  autophagosome  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  cytosol  protein targeting to vacuole  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  intra-Golgi vesicle-mediated transport  Golgi to vacuole transport  autophagy  synaptic vesicle  ER to Golgi transport vesicle membrane  integral component of membrane  clathrin-coated vesicle  SNARE complex  SNARE complex  SNARE complex  late endosome membrane  trans-Golgi network membrane  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  retrograde transport, endosome to Golgi  neuronal cell body  intracellular membrane-bounded organelle  neuron projection terminus  vesicle fusion with Golgi apparatus  vesicle fusion with Golgi apparatus  perinuclear region of cytoplasm  voluntary musculoskeletal movement  Golgi ribbon formation  
Pathways : KEGGSNARE interactions in vesicular transport   
NDEx NetworkVTI1A
Atlas of Cancer Signalling NetworkVTI1A
Wikipedia pathwaysVTI1A
Orthology - Evolution
OrthoDB143187
GeneTree (enSembl)ENSG00000151532
Phylogenetic Trees/Animal Genes : TreeFamVTI1A
HOGENOMQ96AJ9
Homologs : HomoloGeneVTI1A
Homology/Alignments : Family Browser (UCSC)VTI1A
Gene fusions - Rearrangements
Fusion : MitelmanC1orf95/VTI1A [1q42.12/10q25.2]  [t(1;10)(q42;q25)]  
Fusion : MitelmanFAM160B1/VTI1A [10q25.3/10q25.2]  [t(10;10)(q25;q25)]  
Fusion : MitelmanVTI1A/C10orf90 [10q25.2/10q26.2]  [t(10;10)(q25;q26)]  
Fusion : MitelmanVTI1A/SUGP2 [10q25.2/19p13.11]  [t(10;19)(q25;p13)]  
Fusion : MitelmanVTI1A/TCF7L2 [10q25.2/10q25.2]  [del(10)(q25q25)]  
Fusion PortalC1orf95 1q42.12 VTI1A 10q25.2 LUAD
Fusion PortalFAM160B1 10q25.3 VTI1A 10q25.2 PRAD
Fusion PortalVTI1A 10q25.2 C10orf90 10q26.2 LUAD
Fusion PortalVTI1A 10q25.2 SUGP2 19p13.11 PRAD
Fusion : QuiverVTI1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVTI1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VTI1A
dbVarVTI1A
ClinVarVTI1A
1000_GenomesVTI1A 
Exome Variant ServerVTI1A
ExAC (Exome Aggregation Consortium)ENSG00000151532
GNOMAD BrowserENSG00000151532
Varsome BrowserVTI1A
Genetic variants : HAPMAP143187
Genomic Variants (DGV)VTI1A [DGVbeta]
DECIPHERVTI1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVTI1A 
Mutations
ICGC Data PortalVTI1A 
TCGA Data PortalVTI1A 
Broad Tumor PortalVTI1A
OASIS PortalVTI1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVTI1A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVTI1A
Mutations and Diseases : HGMDVTI1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VTI1A
DgiDB (Drug Gene Interaction Database)VTI1A
DoCM (Curated mutations)VTI1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VTI1A (select a term)
intoGenVTI1A
Cancer3DVTI1A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614316   
Orphanet
DisGeNETVTI1A
MedgenVTI1A
Genetic Testing Registry VTI1A
NextProtQ96AJ9 [Medical]
TSGene143187
GENETestsVTI1A
Target ValidationVTI1A
Huge Navigator VTI1A [HugePedia]
snp3D : Map Gene to Disease143187
BioCentury BCIQVTI1A
ClinGenVTI1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD143187
Chemical/Pharm GKB GenePA134928049
Clinical trialVTI1A
Miscellaneous
canSAR (ICR)VTI1A (select the gene name)
DataMed IndexVTI1A
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVTI1A
EVEXVTI1A
GoPubMedVTI1A
iHOPVTI1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:35:09 CEST 2019
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