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VTI1B (vesicle transport through interaction with t-SNAREs 1B)

Identity

Alias (NCBI)VTI1
VTI1-LIKE
VTI1L
VTI2
v-SNARE
vti1-rp1
HGNC (Hugo) VTI1B
HGNC Alias symbVTI2
HGNC Previous namevesicle transport through interaction with t-SNAREs homolog 1B (yeast)
LocusID (NCBI) 10490
Atlas_Id 54770
Location 14q24.1  [Link to chromosome band 14q24]
Location_base_pair Starts at 67647086 and ends at 67674632 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C12orf40 (12q12) / VTI1B (14q24.1)G3BP1 (5q33.1) / VTI1B (14q24.1)VTI1B (14q24.1) / RDH11 (14q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;14)(q24;q24) VTI1B/RDH11

External links

Nomenclature
HGNC (Hugo)VTI1B   17793
Cards
Entrez_Gene (NCBI)VTI1B  10490  vesicle transport through interaction with t-SNAREs 1B
AliasesVTI1; VTI1-LIKE; VTI1L; VTI2; 
v-SNARE; vti1-rp1
GeneCards (Weizmann)VTI1B
Ensembl hg19 (Hinxton)ENSG00000100568 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100568 [Gene_View]  ENSG00000100568 [Sequence]  chr14:67647086-67674632 [Contig_View]  VTI1B [Vega]
ICGC DataPortalENSG00000100568
TCGA cBioPortalVTI1B
AceView (NCBI)VTI1B
Genatlas (Paris)VTI1B
WikiGenes10490
SOURCE (Princeton)VTI1B
Genetics Home Reference (NIH)VTI1B
Genomic and cartography
GoldenPath hg38 (UCSC)VTI1B  -     chr14:67647086-67674632 -  14q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VTI1B  -     14q24.1   [Description]    (hg19-Feb_2009)
GoldenPathVTI1B - 14q24.1 [CytoView hg19]  VTI1B - 14q24.1 [CytoView hg38]
ImmunoBaseENSG00000100568
genome Data Viewer NCBIVTI1B [Mapview hg19]  
OMIM603207   
Gene and transcription
Genbank (Entrez)AF035824 AF060902 AK291689 AK310839 AK316572
RefSeq transcript (Entrez)NM_006370
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VTI1B
Alternative Splicing GalleryENSG00000100568
Gene ExpressionVTI1B [ NCBI-GEO ]   VTI1B [ EBI - ARRAY_EXPRESS ]   VTI1B [ SEEK ]   VTI1B [ MEM ]
Gene Expression Viewer (FireBrowse)VTI1B [ Firebrowse - Broad ]
GenevisibleExpression of VTI1B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10490
GTEX Portal (Tissue expression)VTI1B
Human Protein AtlasENSG00000100568-VTI1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UEU0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UEU0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UEU0
Splice isoforms : SwissVarQ9UEU0
PhosPhoSitePlusQ9UEU0
Domains : Interpro (EBI)SNARE    T_SNARE_dom    v-SNARE_N_sf    Vesicle_trsprt_v-SNARE_N   
Domain families : Pfam (Sanger)V-SNARE (PF05008)   
Domain families : Pfam (NCBI)pfam05008   
Domain families : Smart (EMBL)t_SNARE (SM00397)  
Conserved Domain (NCBI)VTI1B
DMDM Disease mutations10490
Blocks (Seattle)VTI1B
PDB (RSDB)2V8S   
PDB Europe2V8S   
PDB (PDBSum)2V8S   
PDB (IMB)2V8S   
Structural Biology KnowledgeBase2V8S   
SCOP (Structural Classification of Proteins)2V8S   
CATH (Classification of proteins structures)2V8S   
SuperfamilyQ9UEU0
Human Protein Atlas [tissue]ENSG00000100568-VTI1B [tissue]
Peptide AtlasQ9UEU0
HPRD04440
IPIIPI00063784   IPI00386818   IPI01025276   IPI01025018   IPI01025187   IPI01024825   
Protein Interaction databases
DIP (DOE-UCLA)Q9UEU0
IntAct (EBI)Q9UEU0
FunCoupENSG00000100568
BioGRIDVTI1B
STRING (EMBL)VTI1B
ZODIACVTI1B
Ontologies - Pathways
QuickGOQ9UEU0
Ontology : AmiGOSNARE binding  SNARE binding  platelet degranulation  SNAP receptor activity  protein binding  extracellular region  lysosomal membrane  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  cytosol  protein targeting to vacuole  ER to Golgi vesicle-mediated transport  intra-Golgi vesicle-mediated transport  Golgi to vacuole transport  vesicle docking involved in exocytosis  synaptic vesicle  ER to Golgi transport vesicle membrane  integral component of membrane  vesicle-mediated transport  chloride channel inhibitor activity  platelet alpha granule lumen  SNARE complex  early endosome membrane  late endosome membrane  late endosome membrane  vesicle  retrograde transport, endosome to Golgi  neuronal cell body  intracellular membrane-bounded organelle  vesicle fusion with Golgi apparatus  perinuclear region of cytoplasm  recycling endosome  recycling endosome membrane  membrane fusion  autophagosome maturation  regulation of protein localization to plasma membrane  
Ontology : EGO-EBISNARE binding  SNARE binding  platelet degranulation  SNAP receptor activity  protein binding  extracellular region  lysosomal membrane  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  cytosol  protein targeting to vacuole  ER to Golgi vesicle-mediated transport  intra-Golgi vesicle-mediated transport  Golgi to vacuole transport  vesicle docking involved in exocytosis  synaptic vesicle  ER to Golgi transport vesicle membrane  integral component of membrane  vesicle-mediated transport  chloride channel inhibitor activity  platelet alpha granule lumen  SNARE complex  early endosome membrane  late endosome membrane  late endosome membrane  vesicle  retrograde transport, endosome to Golgi  neuronal cell body  intracellular membrane-bounded organelle  vesicle fusion with Golgi apparatus  perinuclear region of cytoplasm  recycling endosome  recycling endosome membrane  membrane fusion  autophagosome maturation  regulation of protein localization to plasma membrane  
Pathways : KEGGSNARE interactions in vesicular transport   
NDEx NetworkVTI1B
Atlas of Cancer Signalling NetworkVTI1B
Wikipedia pathwaysVTI1B
Orthology - Evolution
OrthoDB10490
GeneTree (enSembl)ENSG00000100568
Phylogenetic Trees/Animal Genes : TreeFamVTI1B
HOGENOMQ9UEU0
Homologs : HomoloGeneVTI1B
Homology/Alignments : Family Browser (UCSC)VTI1B
Gene fusions - Rearrangements
Fusion : MitelmanVTI1B/RDH11 [14q24.1/14q24.1]  
Fusion : QuiverVTI1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVTI1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VTI1B
dbVarVTI1B
ClinVarVTI1B
MonarchVTI1B
1000_GenomesVTI1B 
Exome Variant ServerVTI1B
GNOMAD BrowserENSG00000100568
Varsome BrowserVTI1B
Genetic variants : HAPMAP10490
Genomic Variants (DGV)VTI1B [DGVbeta]
DECIPHERVTI1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVTI1B 
Mutations
ICGC Data PortalVTI1B 
TCGA Data PortalVTI1B 
Broad Tumor PortalVTI1B
OASIS PortalVTI1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVTI1B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVTI1B
Mutations and Diseases : HGMDVTI1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VTI1B
DgiDB (Drug Gene Interaction Database)VTI1B
DoCM (Curated mutations)VTI1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VTI1B (select a term)
intoGenVTI1B
Cancer3DVTI1B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603207   
Orphanet
DisGeNETVTI1B
MedgenVTI1B
Genetic Testing Registry VTI1B
NextProtQ9UEU0 [Medical]
TSGene10490
GENETestsVTI1B
Target ValidationVTI1B
Huge Navigator VTI1B [HugePedia]
snp3D : Map Gene to Disease10490
BioCentury BCIQVTI1B
ClinGenVTI1B
Clinical trials, drugs, therapy
Protein Interactions : CTD10490
Pharm GKB GenePA134861090
Clinical trialVTI1B
Miscellaneous
canSAR (ICR)VTI1B (select the gene name)
HarmonizomeVTI1B
DataMed IndexVTI1B
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVTI1B
EVEXVTI1B
GoPubMedVTI1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:38:54 CEST 2020
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