VTN (vitronectin)

2003-08-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
V75,VN,VNT
FUSION GENES

Other Information

Locus ID:

NCBI: 7448
MIM: 193190
HGNC: 12724
Ensembl: ENSG00000109072

Variants:

dbSNP: 7448
ClinVar: 7448
TCGA: ENSG00000109072
COSMIC: VTN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109072ENST00000226218P04004
ENSG00000109072ENST00000226218D9ZGG2
ENSG00000109072ENST00000542029F5GX75

Expression (GTEx)

0
500
1000
1500
2000
2500
3000

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Complement and coagulation cascadesKEGGko04610
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Complement and coagulation cascadesKEGGhsa04610
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Regulation of Complement cascadeREACTOMER-HSA-977606
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
Syndecan interactionsREACTOMER-HSA-3000170
ECM proteoglycansREACTOMER-HSA-3000178
Integrin cell surface interactionsREACTOMER-HSA-216083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183403782008The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.125
151238852004Adhesion to Vitronectin and Collagen I Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells.94
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
188422942008Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.65
158433722005Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.61
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
157179242005Novel hepatocyte growth factor (HGF) binding domains on fibronectin and vitronectin coordinate a distinct and amplified Met-integrin induced signalling pathway in endothelial cells.50
191182182009Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells.50
168152992006Vitronectin and collagen I differentially regulate osteogenesis in mesenchymal stem cells.41
183764152008Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes.37

Citation

Dessen P

VTN (vitronectin)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42800/vtn