Atlas of Genetics and Cytogenetics in Oncology and Haematology

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VWCE (von Willebrand factor C and EGF domains)

Identity

Alias (NCBI)URG11
VWC1
HGNC (Hugo) VWCE
HGNC Alias symbURG11
FLJ32009
VWC1
LocusID (NCBI) 220001
Atlas_Id 51615
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61258286 and ends at 61295316 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TTLL11 (9q33.2) / VWCE (11q12.2)TTLL11 9q33.2 / VWCE 11q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(9;11)(q33;q12) TTLL11/VWCE

External links

Nomenclature
HGNC (Hugo)VWCE   26487
Cards
Entrez_Gene (NCBI)VWCE    von Willebrand factor C and EGF domains
AliasesURG11; VWC1
GeneCards (Weizmann)VWCE
Ensembl hg19 (Hinxton)ENSG00000167992 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167992 [Gene_View]  ENSG00000167992 [Sequence]  chr11:61258286-61295316 [Contig_View]  VWCE [Vega]
ICGC DataPortalENSG00000167992
TCGA cBioPortalVWCE
AceView (NCBI)VWCE
Genatlas (Paris)VWCE
SOURCE (Princeton)VWCE
Genetics Home Reference (NIH)VWCE
Genomic and cartography
GoldenPath hg38 (UCSC)VWCE  -     chr11:61258286-61295316 -  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VWCE  -     11q12.2   [Description]    (hg19-Feb_2009)
GoldenPathVWCE - 11q12.2 [CytoView hg19]  VWCE - 11q12.2 [CytoView hg38]
ImmunoBaseENSG00000167992
genome Data Viewer NCBIVWCE [Mapview hg19]  
OMIM611115   
Gene and transcription
Genbank (Entrez)AA328361 AK056571 AK299583 AK302241 AY205235
RefSeq transcript (Entrez)NM_152718
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VWCE
Alternative Splicing GalleryENSG00000167992
Gene ExpressionVWCE [ NCBI-GEO ]   VWCE [ EBI - ARRAY_EXPRESS ]   VWCE [ SEEK ]   VWCE [ MEM ]
Gene Expression Viewer (FireBrowse)VWCE [ Firebrowse - Broad ]
GenevisibleExpression of VWCE in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)220001
GTEX Portal (Tissue expression)VWCE
Human Protein AtlasENSG00000167992-VWCE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96DN2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96DN2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96DN2
Splice isoforms : SwissVarQ96DN2
PhosPhoSitePlusQ96DN2
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    VWFC_1 (PS01208)    VWFC_2 (PS50184)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Growth_fac_rcpt_cys_sf    VWF_dom   
Domain families : Pfam (Sanger)EGF_CA (PF07645)    VWC (PF00093)   
Domain families : Pfam (NCBI)pfam07645    pfam00093   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  VWC (SM00214)  VWC_out (SM00215)  
Conserved Domain (NCBI)VWCE
Blocks (Seattle)VWCE
SuperfamilyQ96DN2
Human Protein Atlas [tissue]ENSG00000167992-VWCE [tissue]
Peptide AtlasQ96DN2
HPRD08116
IPIIPI00061007   IPI00884977   IPI01009722   IPI00909185   
Protein Interaction databases
DIP (DOE-UCLA)Q96DN2
IntAct (EBI)Q96DN2
BioGRIDVWCE
STRING (EMBL)VWCE
ZODIACVWCE
Ontologies - Pathways
QuickGOQ96DN2
Ontology : AmiGOmolecular_function  calcium ion binding  extracellular region  cytoplasm  cytoplasm  cellular response to virus  cellular response to virus  
Ontology : EGO-EBImolecular_function  calcium ion binding  extracellular region  cytoplasm  cytoplasm  cellular response to virus  cellular response to virus  
NDEx NetworkVWCE
Atlas of Cancer Signalling NetworkVWCE
Wikipedia pathwaysVWCE
Orthology - Evolution
OrthoDB220001
GeneTree (enSembl)ENSG00000167992
Phylogenetic Trees/Animal Genes : TreeFamVWCE
HOGENOMQ96DN2
Homologs : HomoloGeneVWCE
Homology/Alignments : Family Browser (UCSC)VWCE
Gene fusions - Rearrangements
Fusion : MitelmanTTLL11/VWCE [9q33.2/11q12.2]  
Fusion PortalTTLL11 9q33.2 VWCE 11q12.2 OV
Fusion : QuiverVWCE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVWCE [hg38]
dbVarVWCE
ClinVarVWCE
MonarchVWCE
1000_GenomesVWCE 
Exome Variant ServerVWCE
GNOMAD BrowserENSG00000167992
Varsome BrowserVWCE
Genomic Variants (DGV)VWCE [DGVbeta]
DECIPHERVWCE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVWCE 
Mutations
ICGC Data PortalVWCE 
TCGA Data PortalVWCE 
Broad Tumor PortalVWCE
OASIS PortalVWCE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVWCE  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DVWCE
Mutations and Diseases : HGMDVWCE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VWCE
DgiDB (Drug Gene Interaction Database)VWCE
DoCM (Curated mutations)VWCE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VWCE (select a term)
intoGenVWCE
Cancer3DVWCE(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611115   
Orphanet
DisGeNETVWCE
MedgenVWCE
Genetic Testing Registry VWCE
NextProtQ96DN2 [Medical]
GENETestsVWCE
Target ValidationVWCE
Huge Navigator VWCE [HugePedia]
ClinGenVWCE
Clinical trials, drugs, therapy
MyCancerGenomeVWCE
Protein Interactions : CTD
Pharm GKB GenePA143485669
PharosQ96DN2
Clinical trialVWCE
Miscellaneous
canSAR (ICR)VWCE (select the gene name)
HarmonizomeVWCE
DataMed IndexVWCE
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXVWCE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:44:13 CET 2021
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