VWF (von Willebrand factor)

Identity

Other names	F8VWF
	VWD
HGNC	VWF
Location	12p13.3
Location_base_pair	Starts at 5928301 and ends at 6104097 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	VWF   12726
Entrez_Gene	VWF  7450  von Willebrand factor
	Cards
GeneCards	VWF
Ensembl	ENSG00000110799 [Gene_View]  VWF [Vega]
Genatlas	VWF
	Genomic and cartography
GoldenPath	VWF  -  12p13.3   chr12:5928301-6104097 -  12p13.31   [Description]    (hg18-March_2006)
Ensembl	VWF - 12p13.31 [CytoView]
NCBI	Mapview
OMIM	193400 Disease map [OMIM]
HomoloGene	VWF
	Gene and transcription
Genbank	AF086470 [ ENTREZ ]
Genbank	AK292122 [ ENTREZ ]
Genbank	BC022258 [ ENTREZ ]
Genbank	BG951111 [ ENTREZ ]
Genbank	BQ898017 [ ENTREZ ]
RefSeq	NM_000552 [ SRS ]    NM_000552 [ ENTREZ ]
RefSeq	AC_000055 [ SRS ]    AC_000055 [ ENTREZ ]
RefSeq	AC_000144 [ SRS ]    AC_000144 [ ENTREZ ]
RefSeq	NC_000012 [ SRS ]    NC_000012 [ ENTREZ ]
RefSeq	NT_009759 [ SRS ]    NT_009759 [ ENTREZ ]
RefSeq	NW_001838050 [ SRS ]    NW_001838050 [ ENTREZ ]
RefSeq	NW_925295 [ SRS ]    NW_925295 [ ENTREZ ]
CCDS	VWF CCDS - NCBI
AceView	VWF AceView - NCBI
Unigene	Hs.440848 [ SRS ]    Hs.440848 [ NCBI ]
Fast-db	862 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P04275 [ SRS]    P04275 [ EXPASY ]     P04275 [ INTERPRO ]     P04275 [ UNIPROT ] P04275 [ VarSplice FASTA ]
Prosite	PS01185 CTCK_1 [ SRS ]    PS01185 CTCK_1 [ Expasy ]
Prosite	PS01225 CTCK_2 [ SRS ]    PS01225 CTCK_2 [ Expasy ]
Prosite	PS50234 VWFA [ SRS ]    PS50234 VWFA [ Expasy ]
Prosite	PS01208 VWFC_1 [ SRS ]    PS01208 VWFC_1 [ Expasy ]
Prosite	PS50184 VWFC_2 [ SRS ]    PS50184 VWFC_2 [ Expasy ]
Prosite	PS51233 VWFD [ SRS ]    PS51233 VWFD [ Expasy ]
Interpro	IPR006207 Cys_knot_C [ SRS ]    IPR006207 Cys_knot_C [ EBI ]
Interpro	IPR014853 DUF1787 [ SRS ]    IPR014853 DUF1787 [ EBI ]
Interpro	IPR002919 Prot_Inh_CR_TIL [ SRS ]    IPR002919 Prot_Inh_CR_TIL [ EBI ]
Interpro	IPR012011 VWF [ SRS ]    IPR012011 VWF [ EBI ]
Interpro	IPR002035 VWF_A [ SRS ]    IPR002035 VWF_A [ EBI ]
Interpro	IPR001007 VWF_C [ SRS ]    IPR001007 VWF_C [ EBI ]
Interpro	IPR001846 VWF_D [ SRS ]    IPR001846 VWF_D [ EBI ]
CluSTr	P04275
Pfam	PF08742 DUF1787 [ SRS ]    PF08742 DUF1787 [ Sanger ]    pfam08742 [ NCBI-CDD ]
Pfam	PF01826 TIL [ SRS ]    PF01826 TIL [ Sanger ]    pfam01826 [ NCBI-CDD ]
Pfam	PF00092 VWA [ SRS ]    PF00092 VWA [ Sanger ]    pfam00092 [ NCBI-CDD ]
Pfam	PF00093 VWC [ SRS ]    PF00093 VWC [ Sanger ]    pfam00093 [ NCBI-CDD ]
Pfam	PF00094 VWD [ SRS ]    PF00094 VWD [ Sanger ]    pfam00094 [ NCBI-CDD ]
Smart	SM00041 CT [EMBL]
Smart	SM00327 VWA [EMBL]
Smart	SM00214 VWC [EMBL]
Smart	SM00216 VWD [EMBL]
Blocks	P04275
PDB	1AO3 [ SRS ]    1AO3 [ PdbSum ],   1AO3 [ IMB ]   1AO3 [ RSDB ]
PDB	1ATZ [ SRS ]    1ATZ [ PdbSum ],   1ATZ [ IMB ]   1ATZ [ RSDB ]
PDB	1AUQ [ SRS ]    1AUQ [ PdbSum ],   1AUQ [ IMB ]   1AUQ [ RSDB ]
PDB	1FE8 [ SRS ]    1FE8 [ PdbSum ],   1FE8 [ IMB ]   1FE8 [ RSDB ]
PDB	1FNS [ SRS ]    1FNS [ PdbSum ],   1FNS [ IMB ]   1FNS [ RSDB ]
PDB	1IJB [ SRS ]    1IJB [ PdbSum ],   1IJB [ IMB ]   1IJB [ RSDB ]
PDB	1IJK [ SRS ]    1IJK [ PdbSum ],   1IJK [ IMB ]   1IJK [ RSDB ]
PDB	1M10 [ SRS ]    1M10 [ PdbSum ],   1M10 [ IMB ]   1M10 [ RSDB ]
PDB	1OAK [ SRS ]    1OAK [ PdbSum ],   1OAK [ IMB ]   1OAK [ RSDB ]
PDB	1SQ0 [ SRS ]    1SQ0 [ PdbSum ],   1SQ0 [ IMB ]   1SQ0 [ RSDB ]
PDB	1U0N [ SRS ]    1U0N [ PdbSum ],   1U0N [ IMB ]   1U0N [ RSDB ]
PDB	1UEX [ SRS ]    1UEX [ PdbSum ],   1UEX [ IMB ]   1UEX [ RSDB ]
PDB	2ADF [ SRS ]    2ADF [ PdbSum ],   2ADF [ IMB ]   2ADF [ RSDB ]
HPRD	01906
	Protein Interaction databases
DIP	P04275
IntAct	P04275
	Polymorphism : SNP, mutations, diseases
OMIM	193400    [ map ]
GENETests	193400
SNP	VWF [dbSNP-NCBI]
SNP	NM_000552 [SNP-NCI]
SNP	VWF [GeneSNPs - Utah]  VWF] [HGBASE - SRS]
HAPMAP	VWF [HAPMAP]
HGMD	VWF
Genetic Association	VWF
CDC HuGE	VWF
	General knowledge
Family Browser	VWF [UCSC Family Browser]
SOURCE	NM_000552
SMD	Hs.440848
SAGE	Hs.440848
GO	glycoprotein binding [Amigo]  glycoprotein binding
GO	protease binding [Amigo]  protease binding
GO	integrin binding [Amigo]  integrin binding
GO	collagen binding [Amigo]  collagen binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	proteinaceous extracellular matrix [Amigo]  proteinaceous extracellular matrix
GO	endoplasmic reticulum [Amigo]  endoplasmic reticulum
GO	plasma membrane [Amigo]  plasma membrane
GO	response to wounding [Amigo]  response to wounding
GO	immunoglobulin binding [Amigo]  immunoglobulin binding
GO	platelet activation [Amigo]  platelet activation
GO	platelet activation [Amigo]  platelet activation
GO	platelet alpha granule [Amigo]  platelet alpha granule
GO	cell-substrate adhesion [Amigo]  cell-substrate adhesion
GO	Weibel-Palade body [Amigo]  Weibel-Palade body
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	protein N-terminus binding [Amigo]  protein N-terminus binding
GO	chaperone binding [Amigo]  chaperone binding
GO	protein homooligomerization [Amigo]  protein homooligomerization
KEGG	Cell Communication
KEGG	Focal adhesion
KEGG	ECM-receptor interaction
KEGG	Complement and coagulation cascades
PubGene	VWF
TreeFam	VWF
CTD	7450 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	VWF Related clones (RZPD - Berlin)
	PubMed
PubMed	303 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:19:07 2008