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WAC (WW domain containing adaptor with coiled-coil)

Identity

Alias_namesWW domain-containing adaptor with coiled coil
Alias_symbol (synonym)Wwp4
FLJ31290
PRO1741
BM-016
MGC10753
Other aliasDESSH
HGNC (Hugo) WAC
LocusID (NCBI) 51322
Atlas_Id 54771
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 28533492 and ends at 28623112 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNN2 (19p13.3) / WAC (10p12.1)LGALS8 (1q43) / WAC (10p12.1)MAP3K14 (17q21.31) / WAC (10p12.1)
PRKD1 (14q12) / WAC (10p12.1)TMSB10 (2p11.2) / WAC (10p12.1)WAC (10p12.1) / APBB1IP (10p12.1)
WAC (10p12.1) / GPR158 (10p12.1)WAC (10p12.1) / MAP3K14 (17q21.31)WAC (10p12.1) / NRP1 (10p11.22)
WAC (10p12.1) / RDX (11q22.3)WAC (10p12.1) / UBAC2 (13q32.3)WAC (10p12.1) / VPS35 (16q11.2)
WAC (10p12.1) / WAC (10p12.1)ZEB1 (10p11.22) / WAC (10p12.1)WAC 10p12.1 / APBB1IP 10p12.1
WAC 10p12.1 / RDX 11q22.3WAC 10p12.1 / UBAC2 13q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Small Cell Carcinoma
WAC/APBB1IP (10p12)
WAC/GPR158 (10p12)
t(10;11)(p12;q22) WAC/RDX
t(10;13)(p12;q32) WAC/UBAC2

External links

Nomenclature
HGNC (Hugo)WAC   17327
Cards
Entrez_Gene (NCBI)WAC  51322  WW domain containing adaptor with coiled-coil
AliasesBM-016; DESSH; PRO1741; Wwp4
GeneCards (Weizmann)WAC
Ensembl hg19 (Hinxton)ENSG00000095787 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095787 [Gene_View]  ENSG00000095787 [Sequence]  chr10:28533492-28623112 [Contig_View]  WAC [Vega]
ICGC DataPortalENSG00000095787
TCGA cBioPortalWAC
AceView (NCBI)WAC
Genatlas (Paris)WAC
WikiGenes51322
SOURCE (Princeton)WAC
Genetics Home Reference (NIH)WAC
Genomic and cartography
GoldenPath hg38 (UCSC)WAC  -     chr10:28533492-28623112 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WAC  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblWAC - 12p13.31 [CytoView hg19]  WAC - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBIWAC [Mapview hg19]  WAC [Mapview hg38]
OMIM615049   616708   
Gene and transcription
Genbank (Entrez)AA424883 AB058747 AB075491 AF116666 AF208858
RefSeq transcript (Entrez)NM_016628 NM_100264 NM_100486
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WAC
Cluster EST : UnigeneHs.743224 [ NCBI ]
CGAP (NCI)Hs.743224
Alternative Splicing GalleryENSG00000095787
Gene ExpressionWAC [ NCBI-GEO ]   WAC [ EBI - ARRAY_EXPRESS ]   WAC [ SEEK ]   WAC [ MEM ]
Gene Expression Viewer (FireBrowse)WAC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51322
GTEX Portal (Tissue expression)WAC
Human Protein AtlasENSG00000095787-WAC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BTA9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BTA9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BTA9
Splice isoforms : SwissVarQ9BTA9
PhosPhoSitePlusQ9BTA9
Domaine pattern : Prosite (Expaxy)WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)WW_dom    WW_dom_sf   
Domain families : Pfam (Sanger)WW (PF00397)   
Domain families : Pfam (NCBI)pfam00397   
Domain families : Smart (EMBL)WW (SM00456)  
Conserved Domain (NCBI)WAC
DMDM Disease mutations51322
Blocks (Seattle)WAC
SuperfamilyQ9BTA9
Human Protein Atlas [tissue]ENSG00000095787-WAC [tissue]
Peptide AtlasQ9BTA9
HPRD18291
IPIIPI00256605   IPI00478665   IPI00152381   IPI00087375   IPI00333693   IPI00383357   IPI01009548   IPI00924579   IPI00927571   IPI00927788   IPI00925490   IPI00925561   IPI00925032   IPI01013229   
Protein Interaction databases
DIP (DOE-UCLA)Q9BTA9
IntAct (EBI)Q9BTA9
FunCoupENSG00000095787
BioGRIDWAC
STRING (EMBL)WAC
ZODIACWAC
Ontologies - Pathways
QuickGOQ9BTA9
Ontology : AmiGORNA polymerase II core binding  chromatin binding  protein binding  nucleus  nucleoplasm  nucleoplasm  spliceosomal complex  transcription, DNA-templated  cellular response to DNA damage stimulus  histone monoubiquitination  positive regulation of macroautophagy  protein ubiquitination  nuclear speck  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  G1 DNA damage checkpoint  positive regulation of transcription, DNA-templated  histone H2B conserved C-terminal lysine ubiquitination  
Ontology : EGO-EBIRNA polymerase II core binding  chromatin binding  protein binding  nucleus  nucleoplasm  nucleoplasm  spliceosomal complex  transcription, DNA-templated  cellular response to DNA damage stimulus  histone monoubiquitination  positive regulation of macroautophagy  protein ubiquitination  nuclear speck  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  G1 DNA damage checkpoint  positive regulation of transcription, DNA-templated  histone H2B conserved C-terminal lysine ubiquitination  
NDEx NetworkWAC
Atlas of Cancer Signalling NetworkWAC
Wikipedia pathwaysWAC
Orthology - Evolution
OrthoDB51322
GeneTree (enSembl)ENSG00000095787
Phylogenetic Trees/Animal Genes : TreeFamWAC
HOVERGENQ9BTA9
HOGENOMQ9BTA9
Homologs : HomoloGeneWAC
Homology/Alignments : Family Browser (UCSC)WAC
Gene fusions - Rearrangements
Fusion : MitelmanWAC/APBB1IP [10p12.1/10p12.1]  
Fusion : MitelmanWAC/GPR158 [10p12.1/10p12.1]  [t(10;10)(p12;p12)]  
Fusion : MitelmanWAC/RDX [10p12.1/11q22.3]  [t(10;11)(p12;q22)]  
Fusion : MitelmanWAC/UBAC2 [10p12.1/13q32.3]  [t(10;13)(p12;q32)]  
Fusion PortalWAC 10p12.1 APBB1IP 10p12.1 BRCA
Fusion PortalWAC 10p12.1 RDX 11q22.3 LUAD
Fusion PortalWAC 10p12.1 UBAC2 13q32.3 BRCA
Fusion : QuiverWAC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWAC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WAC
dbVarWAC
ClinVarWAC
1000_GenomesWAC 
Exome Variant ServerWAC
ExAC (Exome Aggregation Consortium)ENSG00000095787
GNOMAD BrowserENSG00000095787
Varsome BrowserWAC
Genetic variants : HAPMAP51322
Genomic Variants (DGV)WAC [DGVbeta]
DECIPHERWAC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWAC 
Mutations
ICGC Data PortalWAC 
TCGA Data PortalWAC 
Broad Tumor PortalWAC
OASIS PortalWAC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWAC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWAC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WAC
DgiDB (Drug Gene Interaction Database)WAC
DoCM (Curated mutations)WAC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WAC (select a term)
intoGenWAC
Cancer3DWAC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615049    616708   
Orphanet
DisGeNETWAC
MedgenWAC
Genetic Testing Registry WAC
NextProtQ9BTA9 [Medical]
TSGene51322
GENETestsWAC
Target ValidationWAC
Huge Navigator WAC [HugePedia]
snp3D : Map Gene to Disease51322
BioCentury BCIQWAC
ClinGenWAC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51322
Chemical/Pharm GKB GenePA134978936
Clinical trialWAC
Miscellaneous
canSAR (ICR)WAC (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWAC
EVEXWAC
GoPubMedWAC
iHOPWAC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Aug 16 11:41:28 CEST 2018
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