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WAPL (WAPL cohesin release factor)

Identity

Alias_namesKIAA0261
WAPAL
KIAA0261
wings apart-like homolog (Drosophila)
Alias_symbol (synonym)FOE
Other alias
HGNC (Hugo) WAPL
LocusID (NCBI) 23063
Atlas_Id 55307
Location 10q23.2  [Link to chromosome band 10q23]
Location_base_pair Starts at 86435256 and ends at 86521784 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GARS (7p14.3) / WAPL (10q23.2)LARS (5q32) / WAPL (10q23.2)SRP9 (1q42.12) / WAPL (10q23.2)
WAPL (10q23.2) / PTPRT (20q12)WAPL (10q23.2) / ZCCHC4 (4p15.2)ZCCHC4 (4p15.2) / WAPL (10q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WAPL   23293
Cards
Entrez_Gene (NCBI)WAPL  23063  WAPL cohesin release factor
AliasesFOE; KIAA0261; WAPAL
GeneCards (Weizmann)WAPL
Ensembl hg19 (Hinxton)ENSG00000062650 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000062650 [Gene_View]  chr10:86435256-86521784 [Contig_View]  WAPL [Vega]
ICGC DataPortalENSG00000062650
TCGA cBioPortalWAPL
AceView (NCBI)WAPL
Genatlas (Paris)WAPL
WikiGenes23063
SOURCE (Princeton)WAPL
Genetics Home Reference (NIH)WAPL
Genomic and cartography
GoldenPath hg38 (UCSC)WAPL  -     chr10:86435256-86521784 -  10q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WAPL  -     10q23.2   [Description]    (hg19-Feb_2009)
EnsemblWAPL - 10q23.2 [CytoView hg19]  WAPL - 10q23.2 [CytoView hg38]
Mapping of homologs : NCBIWAPL [Mapview hg19]  WAPL [Mapview hg38]
OMIM610754   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001318328 NM_015045
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WAPL
Cluster EST : UnigeneHs.714876 [ NCBI ]
CGAP (NCI)Hs.714876
Alternative Splicing GalleryENSG00000062650
Gene ExpressionWAPL [ NCBI-GEO ]   WAPL [ EBI - ARRAY_EXPRESS ]   WAPL [ SEEK ]   WAPL [ MEM ]
Gene Expression Viewer (FireBrowse)WAPL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23063
GTEX Portal (Tissue expression)WAPL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z5K2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z5K2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z5K2
Splice isoforms : SwissVarQ7Z5K2
PhosPhoSitePlusQ7Z5K2
Domaine pattern : Prosite (Expaxy)WAPL (PS51271)   
Domains : Interpro (EBI)ARM-type_fold    WAPL_dom    WAPL_prot   
Domain families : Pfam (Sanger)WAPL (PF07814)   
Domain families : Pfam (NCBI)pfam07814   
Conserved Domain (NCBI)WAPL
DMDM Disease mutations23063
Blocks (Seattle)WAPL
PDB (SRS)4K6J    5HDT   
PDB (PDBSum)4K6J    5HDT   
PDB (IMB)4K6J    5HDT   
PDB (RSDB)4K6J    5HDT   
Structural Biology KnowledgeBase4K6J    5HDT   
SCOP (Structural Classification of Proteins)4K6J    5HDT   
CATH (Classification of proteins structures)4K6J    5HDT   
SuperfamilyQ7Z5K2
Human Protein AtlasENSG00000062650
Peptide AtlasQ7Z5K2
HPRD11072
IPIIPI00375330   IPI00744918   IPI00412441   IPI01019057   IPI01015151   IPI00103263   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z5K2
IntAct (EBI)Q7Z5K2
FunCoupENSG00000062650
BioGRIDWAPL
STRING (EMBL)WAPL
ZODIACWAPL
Ontologies - Pathways
QuickGOQ7Z5K2
Ontology : AmiGOchromosome, centromeric region  chromatin  synaptonemal complex  protein binding  nucleus  nucleoplasm  chromosome  cytoplasm  cytosol  sister chromatid cohesion  mitotic sister chromatid cohesion  negative regulation of DNA replication  cohesin complex  response to toxic substance  viral process  negative regulation of chromatin binding  meiotic chromosome segregation  negative regulation of sister chromatid cohesion  positive regulation of fibroblast proliferation  cell division  regulation of chromosome condensation  protein localization to chromatin  regulation of cohesin loading  
Ontology : EGO-EBIchromosome, centromeric region  chromatin  synaptonemal complex  protein binding  nucleus  nucleoplasm  chromosome  cytoplasm  cytosol  sister chromatid cohesion  mitotic sister chromatid cohesion  negative regulation of DNA replication  cohesin complex  response to toxic substance  viral process  negative regulation of chromatin binding  meiotic chromosome segregation  negative regulation of sister chromatid cohesion  positive regulation of fibroblast proliferation  cell division  regulation of chromosome condensation  protein localization to chromatin  regulation of cohesin loading  
NDEx NetworkWAPL
Atlas of Cancer Signalling NetworkWAPL
Wikipedia pathwaysWAPL
Orthology - Evolution
OrthoDB23063
GeneTree (enSembl)ENSG00000062650
Phylogenetic Trees/Animal Genes : TreeFamWAPL
HOVERGENQ7Z5K2
HOGENOMQ7Z5K2
Homologs : HomoloGeneWAPL
Homology/Alignments : Family Browser (UCSC)WAPL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWAPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WAPL
dbVarWAPL
ClinVarWAPL
1000_GenomesWAPL 
Exome Variant ServerWAPL
ExAC (Exome Aggregation Consortium)WAPL (select the gene name)
Genetic variants : HAPMAP23063
Genomic Variants (DGV)WAPL [DGVbeta]
DECIPHERWAPL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWAPL 
Mutations
ICGC Data PortalWAPL 
TCGA Data PortalWAPL 
Broad Tumor PortalWAPL
OASIS PortalWAPL [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDWAPL
BioMutasearch WAPL
DgiDB (Drug Gene Interaction Database)WAPL
DoCM (Curated mutations)WAPL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WAPL (select a term)
intoGenWAPL
Cancer3DWAPL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610754   
Orphanet
MedgenWAPL
Genetic Testing Registry WAPL
NextProtQ7Z5K2 [Medical]
TSGene23063
GENETestsWAPL
Target ValidationWAPL
Huge Navigator WAPL [HugePedia]
snp3D : Map Gene to Disease23063
BioCentury BCIQWAPL
ClinGenWAPL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23063
Chemical/Pharm GKB GenePA134872402
Clinical trialWAPL
Miscellaneous
canSAR (ICR)WAPL (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWAPL
EVEXWAPL
GoPubMedWAPL
iHOPWAPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:38:09 CEST 2017

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