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WAPL (WAPL cohesin release factor)

Identity

Alias (NCBI)FOE
KIAA0261
WAPAL
HGNC (Hugo) WAPL
HGNC Alias symbFOE
HGNC Alias namefriend of EBNA2
HGNC Previous nameKIAA0261
 WAPAL
HGNC Previous nameKIAA0261
 wings apart-like homolog (Drosophila)
LocusID (NCBI) 23063
Atlas_Id 55307
Location 10q23.2  [Link to chromosome band 10q23]
Location_base_pair Starts at 86435256 and ends at 86521792 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GARS (7p14.3) / WAPL (10q23.2)LARS (5q32) / WAPL (10q23.2)SRP9 (1q42.12) / WAPL (10q23.2)
WAPL (10q23.2) / PTPRT (20q12)WAPL (10q23.2) / ZCCHC4 (4p15.2)ZCCHC4 (4p15.2) / WAPL (10q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)WAPL   23293
Cards
Entrez_Gene (NCBI)WAPL    WAPL cohesin release factor
AliasesFOE; KIAA0261; WAPAL
GeneCards (Weizmann)WAPL
Ensembl hg19 (Hinxton)ENSG00000062650 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000062650 [Gene_View]  ENSG00000062650 [Sequence]  chr10:86435256-86521792 [Contig_View]  WAPL [Vega]
ICGC DataPortalENSG00000062650
TCGA cBioPortalWAPL
AceView (NCBI)WAPL
Genatlas (Paris)WAPL
SOURCE (Princeton)WAPL
Genetics Home Reference (NIH)WAPL
Genomic and cartography
GoldenPath hg38 (UCSC)WAPL  -     chr10:86435256-86521792 -  10q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WAPL  -     10q23.2   [Description]    (hg19-Feb_2009)
GoldenPathWAPL - 10q23.2 [CytoView hg19]  WAPL - 10q23.2 [CytoView hg38]
ImmunoBaseENSG00000062650
Genome Data Viewer NCBIWAPL [Mapview hg19]  
OMIM610754   
Gene and transcription
Genbank (Entrez)AB065003 AB426821 AB426822 AB426823 AB426824
RefSeq transcript (Entrez)NM_001318328 NM_015045
Consensus coding sequences : CCDS (NCBI)WAPL
Gene ExpressionWAPL [ NCBI-GEO ]   WAPL [ EBI - ARRAY_EXPRESS ]   WAPL [ SEEK ]   WAPL [ MEM ]
Gene Expression Viewer (FireBrowse)WAPL [ Firebrowse - Broad ]
GenevisibleExpression of WAPL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23063
GTEX Portal (Tissue expression)WAPL
Human Protein AtlasENSG00000062650-WAPL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z5K2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z5K2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z5K2
PhosPhoSitePlusQ7Z5K2
Domaine pattern : Prosite (Expaxy)WAPL (PS51271)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    WAPL    WAPL_C    WAPL_dom   
Domain families : Pfam (Sanger)WAPL (PF07814)   
Domain families : Pfam (NCBI)pfam07814   
Conserved Domain (NCBI)WAPL
PDB (RSDB)4K6J    5HDT   
PDB Europe4K6J    5HDT   
PDB (PDBSum)4K6J    5HDT   
PDB (IMB)4K6J    5HDT   
Structural Biology KnowledgeBase4K6J    5HDT   
SCOP (Structural Classification of Proteins)4K6J    5HDT   
CATH (Classification of proteins structures)4K6J    5HDT   
SuperfamilyQ7Z5K2
AlphaFold pdb e-kbQ7Z5K2   
Human Protein Atlas [tissue]ENSG00000062650-WAPL [tissue]
HPRD11072
Protein Interaction databases
DIP (DOE-UCLA)Q7Z5K2
IntAct (EBI)Q7Z5K2
BioGRIDWAPL
STRING (EMBL)WAPL
ZODIACWAPL
Ontologies - Pathways
QuickGOQ7Z5K2
Ontology : AmiGOmitotic cell cycle  chromosome, centromeric region  chromatin  synaptonemal complex  protein binding  nucleus  nucleoplasm  nucleoplasm  chromosome  cytoplasm  Golgi apparatus  centrosome  cytosol  cytosol  negative regulation of DNA replication  response to toxic substance  negative regulation of chromatin binding  intercellular bridge  negative regulation of sister chromatid cohesion  positive regulation of fibroblast proliferation  cell division  regulation of chromosome segregation  regulation of chromosome condensation  protein localization to chromatin  regulation of cohesin loading  regulation of cohesin loading  mitotic spindle  
Ontology : EGO-EBImitotic cell cycle  chromosome, centromeric region  chromatin  synaptonemal complex  protein binding  nucleus  nucleoplasm  nucleoplasm  chromosome  cytoplasm  Golgi apparatus  centrosome  cytosol  cytosol  negative regulation of DNA replication  response to toxic substance  negative regulation of chromatin binding  intercellular bridge  negative regulation of sister chromatid cohesion  positive regulation of fibroblast proliferation  cell division  regulation of chromosome segregation  regulation of chromosome condensation  protein localization to chromatin  regulation of cohesin loading  regulation of cohesin loading  mitotic spindle  
NDEx NetworkWAPL
Atlas of Cancer Signalling NetworkWAPL
Wikipedia pathwaysWAPL
Orthology - Evolution
OrthoDB23063
GeneTree (enSembl)ENSG00000062650
Phylogenetic Trees/Animal Genes : TreeFamWAPL
Homologs : HomoloGeneWAPL
Homology/Alignments : Family Browser (UCSC)WAPL
Gene fusions - Rearrangements
Fusion : QuiverWAPL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWAPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WAPL
dbVarWAPL
ClinVarWAPL
MonarchWAPL
1000_GenomesWAPL 
Exome Variant ServerWAPL
GNOMAD BrowserENSG00000062650
Varsome BrowserWAPL
ACMGWAPL variants
VarityQ7Z5K2
Genomic Variants (DGV)WAPL [DGVbeta]
DECIPHERWAPL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWAPL 
Mutations
ICGC Data PortalWAPL 
TCGA Data PortalWAPL 
Broad Tumor PortalWAPL
OASIS PortalWAPL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWAPL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWAPL
Mutations and Diseases : HGMDWAPL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaWAPL
DgiDB (Drug Gene Interaction Database)WAPL
DoCM (Curated mutations)WAPL
CIViC (Clinical Interpretations of Variants in Cancer)WAPL
Cancer3DWAPL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610754   
Orphanet
DisGeNETWAPL
MedgenWAPL
Genetic Testing Registry WAPL
NextProtQ7Z5K2 [Medical]
GENETestsWAPL
Target ValidationWAPL
Huge Navigator WAPL [HugePedia]
ClinGenWAPL
Clinical trials, drugs, therapy
MyCancerGenomeWAPL
Protein Interactions : CTDWAPL
Pharm GKB GenePA134872402
PharosQ7Z5K2
Clinical trialWAPL
Miscellaneous
canSAR (ICR)WAPL
HarmonizomeWAPL
DataMed IndexWAPL
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWAPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:38:12 CEST 2021

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