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WARS (tryptophanyl-tRNA synthetase)

Identity

Alias_namescytoplasmic
IFI53
Alias_symbol (synonym)IFP53
Other aliasGAMMA-2
HGNC (Hugo) WARS
LocusID (NCBI) 7453
Atlas_Id 51355
Location 14q32.2  [Link to chromosome band 14q32]
Location_base_pair Starts at 100333788 and ends at 100375590 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GADD45G (9q22.2) / WARS (14q32.2)MARK3 (14q32.32) / WARS (14q32.2)WARS (14q32.2) / CCNY (10p11.21)
WARS (14q32.2) / FAM167A-AS1 (8p23.1)WARS (14q32.2) / KTN1 (14q22.3)WARS (14q32.2) / NFYC (1p34.2)
WARS (14q32.2) / PPP2R3C (14q13.2)WARS (14q32.2) / WARS (14q32.2)ZNF695 (1q44) / WARS (14q32.2)
WARS 14q32.2 C8orf12WARS 14q32.2 / CCNY 10p11.21WARS 14q32.2 / PPP2R3C 14q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WARS   12729
Cards
Entrez_Gene (NCBI)WARS  7453  tryptophanyl-tRNA synthetase
AliasesGAMMA-2; IFI53; IFP53
GeneCards (Weizmann)WARS
Ensembl hg19 (Hinxton)ENSG00000140105 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140105 [Gene_View]  chr14:100333788-100375590 [Contig_View]  WARS [Vega]
ICGC DataPortalENSG00000140105
TCGA cBioPortalWARS
AceView (NCBI)WARS
Genatlas (Paris)WARS
WikiGenes7453
SOURCE (Princeton)WARS
Genetics Home Reference (NIH)WARS
Genomic and cartography
GoldenPath hg38 (UCSC)WARS  -     chr14:100333788-100375590 -  14q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WARS  -     14q32.2   [Description]    (hg19-Feb_2009)
EnsemblWARS - 14q32.2 [CytoView hg19]  WARS - 14q32.2 [CytoView hg38]
Mapping of homologs : NCBIWARS [Mapview hg19]  WARS [Mapview hg38]
OMIM191050   
Gene and transcription
Genbank (Entrez)AK025487 AK056100 AK124668 AK130698 AK291141
RefSeq transcript (Entrez)NM_004184 NM_173701 NM_213645 NM_213646
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WARS
Cluster EST : UnigeneHs.497599 [ NCBI ]
CGAP (NCI)Hs.497599
Alternative Splicing GalleryENSG00000140105
Gene ExpressionWARS [ NCBI-GEO ]   WARS [ EBI - ARRAY_EXPRESS ]   WARS [ SEEK ]   WARS [ MEM ]
Gene Expression Viewer (FireBrowse)WARS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7453
GTEX Portal (Tissue expression)WARS
Human Protein AtlasENSG00000140105-WARS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23381   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23381  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23381
Splice isoforms : SwissVarP23381
Catalytic activity : Enzyme6.1.1.2 [ Enzyme-Expasy ]   6.1.1.26.1.1.2 [ IntEnz-EBI ]   6.1.1.2 [ BRENDA ]   6.1.1.2 [ KEGG ]   
PhosPhoSitePlusP23381
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ic    Rossmann-like_a/b/a_fold    S15_NS1_RNA-bd    Trp-tRNA-ligase    WHEP-TRS_dom   
Domain families : Pfam (Sanger)tRNA-synt_1b (PF00579)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam00579    pfam00458   
Domain families : Smart (EMBL)WHEP-TRS (SM00991)  
Conserved Domain (NCBI)WARS
DMDM Disease mutations7453
Blocks (Seattle)WARS
PDB (SRS)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK   
PDB (PDBSum)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK   
PDB (IMB)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK   
PDB (RSDB)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK   
Structural Biology KnowledgeBase1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK   
SCOP (Structural Classification of Proteins)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK   
CATH (Classification of proteins structures)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK   
SuperfamilyP23381
Human Protein Atlas [tissue]ENSG00000140105-WARS [tissue]
Peptide AtlasP23381
HPRD01845
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)P23381
IntAct (EBI)P23381
FunCoupENSG00000140105
BioGRIDWARS
STRING (EMBL)WARS
ZODIACWARS
Ontologies - Pathways
QuickGOP23381
Ontology : AmiGOangiogenesis  negative regulation of protein phosphorylation  tryptophan-tRNA ligase activity  tryptophan-tRNA ligase activity  tryptophan-tRNA ligase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  tryptophanyl-tRNA aminoacylation  tryptophanyl-tRNA aminoacylation  negative regulation of protein kinase activity  negative regulation of cell proliferation  positive regulation of gene expression  regulation of protein ADP-ribosylation  kinase inhibitor activity  protein kinase binding  protein domain specific binding  positive regulation of protein complex assembly  protein homodimerization activity  protein complex  regulation of angiogenesis  extracellular exosome  
Ontology : EGO-EBIangiogenesis  negative regulation of protein phosphorylation  tryptophan-tRNA ligase activity  tryptophan-tRNA ligase activity  tryptophan-tRNA ligase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  tryptophanyl-tRNA aminoacylation  tryptophanyl-tRNA aminoacylation  negative regulation of protein kinase activity  negative regulation of cell proliferation  positive regulation of gene expression  regulation of protein ADP-ribosylation  kinase inhibitor activity  protein kinase binding  protein domain specific binding  positive regulation of protein complex assembly  protein homodimerization activity  protein complex  regulation of angiogenesis  extracellular exosome  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkWARS
Atlas of Cancer Signalling NetworkWARS
Wikipedia pathwaysWARS
Orthology - Evolution
OrthoDB7453
GeneTree (enSembl)ENSG00000140105
Phylogenetic Trees/Animal Genes : TreeFamWARS
HOVERGENP23381
HOGENOMP23381
Homologs : HomoloGeneWARS
Homology/Alignments : Family Browser (UCSC)WARS
Gene fusions - Rearrangements
Fusion : MitelmanWARS/CCNY [14q32.2/10p11.21]  
Fusion : MitelmanWARS/FAM167A-AS1 [14q32.2/8p23.1]  [t(8;14)(p23;q32)]  
Fusion : MitelmanWARS/KTN1 [14q32.2/14q22.3]  [t(14;14)(q22;q32)]  
Fusion : MitelmanWARS/PPP2R3C [14q32.2/14q13.2]  [t(14;14)(q13;q32)]  
Fusion: TCGA_MDACCWARS 14q32.2 C8orf12 LUAD
Fusion: TCGA_MDACCWARS 14q32.2 CCNY 10p11.21 THCA
Fusion: TCGA_MDACCWARS 14q32.2 PPP2R3C 14q13.2 LUAD
Tumor Fusion PortalWARS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWARS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WARS
dbVarWARS
ClinVarWARS
1000_GenomesWARS 
Exome Variant ServerWARS
ExAC (Exome Aggregation Consortium)ENSG00000140105
GNOMAD BrowserENSG00000140105
Genetic variants : HAPMAP7453
Genomic Variants (DGV)WARS [DGVbeta]
DECIPHERWARS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWARS 
Mutations
ICGC Data PortalWARS 
TCGA Data PortalWARS 
Broad Tumor PortalWARS
OASIS PortalWARS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWARS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWARS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WARS
DgiDB (Drug Gene Interaction Database)WARS
DoCM (Curated mutations)WARS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WARS (select a term)
intoGenWARS
Cancer3DWARS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191050   
Orphanet
DisGeNETWARS
MedgenWARS
Genetic Testing Registry WARS
NextProtP23381 [Medical]
TSGene7453
GENETestsWARS
Target ValidationWARS
Huge Navigator WARS [HugePedia]
snp3D : Map Gene to Disease7453
BioCentury BCIQWARS
ClinGenWARS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7453
Chemical/Pharm GKB GenePA37340
Clinical trialWARS
Miscellaneous
canSAR (ICR)WARS (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWARS
EVEXWARS
GoPubMedWARS
iHOPWARS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:41:30 CET 2017

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