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WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial)

Identity

Alias_symbol (synonym)TrpRS
Other alias
HGNC (Hugo) WARS2
LocusID (NCBI) 10352
Atlas_Id 75675
Location 1p12  [Link to chromosome band 1p12]
Location_base_pair Starts at 119031216 and ends at 119140672 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KIAA1549L (11p13) / WARS2 (1p12)VAV3 (1p13.3) / WARS2 (1p12)WARS2 (1p12) / LOXL2 (8p21.3)
WARS2 (1p12) / PHGDH (1p12)WARS2 (1p12) / REG4 (1p12)WARS2 (1p12) / RYR2 (1q43)
WARS2 (1p12) / TPST1 (7q11.21)WARS2 TPST1WARS2 REG4
WARS2 PHGDH

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WARS2   12730
Cards
Entrez_Gene (NCBI)WARS2  10352  tryptophanyl tRNA synthetase 2, mitochondrial
AliasesTrpRS
GeneCards (Weizmann)WARS2
Ensembl hg19 (Hinxton)ENSG00000116874 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116874 [Gene_View]  chr1:119031216-119140672 [Contig_View]  WARS2 [Vega]
ICGC DataPortalENSG00000116874
TCGA cBioPortalWARS2
AceView (NCBI)WARS2
Genatlas (Paris)WARS2
WikiGenes10352
SOURCE (Princeton)WARS2
Genetics Home Reference (NIH)WARS2
Genomic and cartography
GoldenPath hg38 (UCSC)WARS2  -     chr1:119031216-119140672 -  1p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WARS2  -     1p12   [Description]    (hg19-Feb_2009)
EnsemblWARS2 - 1p12 [CytoView hg19]  WARS2 - 1p12 [CytoView hg38]
Mapping of homologs : NCBIWARS2 [Mapview hg19]  WARS2 [Mapview hg38]
OMIM604733   
Gene and transcription
Genbank (Entrez)AJ242739 AK223197 AK296088 AK296799 AK299547
RefSeq transcript (Entrez)NM_015836 NM_201263
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WARS2
Cluster EST : UnigeneHs.523506 [ NCBI ]
CGAP (NCI)Hs.523506
Alternative Splicing GalleryENSG00000116874
Gene ExpressionWARS2 [ NCBI-GEO ]   WARS2 [ EBI - ARRAY_EXPRESS ]   WARS2 [ SEEK ]   WARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)WARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10352
GTEX Portal (Tissue expression)WARS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGM6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGM6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGM6
Splice isoforms : SwissVarQ9UGM6
Catalytic activity : Enzyme6.1.1.2 [ Enzyme-Expasy ]   6.1.1.26.1.1.2 [ IntEnz-EBI ]   6.1.1.2 [ BRENDA ]   6.1.1.2 [ KEGG ]   
PhosPhoSitePlusQ9UGM6
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ic    Rossmann-like_a/b/a_fold    Trp-tRNA-ligase    Trp-tRNA-ligase_bac-type   
Domain families : Pfam (Sanger)tRNA-synt_1b (PF00579)   
Domain families : Pfam (NCBI)pfam00579   
Conserved Domain (NCBI)WARS2
DMDM Disease mutations10352
Blocks (Seattle)WARS2
PDB (SRS)5EKD   
PDB (PDBSum)5EKD   
PDB (IMB)5EKD   
PDB (RSDB)5EKD   
Structural Biology KnowledgeBase5EKD   
SCOP (Structural Classification of Proteins)5EKD   
CATH (Classification of proteins structures)5EKD   
SuperfamilyQ9UGM6
Human Protein AtlasENSG00000116874
Peptide AtlasQ9UGM6
HPRD05295
IPIIPI00025050   IPI00397465   IPI01009932   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGM6
IntAct (EBI)Q9UGM6
FunCoupENSG00000116874
BioGRIDWARS2
STRING (EMBL)WARS2
ZODIACWARS2
Ontologies - Pathways
QuickGOQ9UGM6
Ontology : AmiGOvasculogenesis  tryptophan-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  mitochondrial matrix  plasma membrane  tRNA aminoacylation for protein translation  tryptophanyl-tRNA aminoacylation  
Ontology : EGO-EBIvasculogenesis  tryptophan-tRNA ligase activity  ATP binding  mitochondrion  mitochondrial matrix  mitochondrial matrix  plasma membrane  tRNA aminoacylation for protein translation  tryptophanyl-tRNA aminoacylation  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkWARS2
Atlas of Cancer Signalling NetworkWARS2
Wikipedia pathwaysWARS2
Orthology - Evolution
OrthoDB10352
GeneTree (enSembl)ENSG00000116874
Phylogenetic Trees/Animal Genes : TreeFamWARS2
HOVERGENQ9UGM6
HOGENOMQ9UGM6
Homologs : HomoloGeneWARS2
Homology/Alignments : Family Browser (UCSC)WARS2
Gene fusions - Rearrangements
Fusion: TCGAWARS2 TPST1
Fusion: TCGAWARS2 REG4
Fusion: TCGAWARS2 PHGDH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WARS2
dbVarWARS2
ClinVarWARS2
1000_GenomesWARS2 
Exome Variant ServerWARS2
ExAC (Exome Aggregation Consortium)WARS2 (select the gene name)
Genetic variants : HAPMAP10352
Genomic Variants (DGV)WARS2 [DGVbeta]
DECIPHERWARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWARS2 
Mutations
ICGC Data PortalWARS2 
TCGA Data PortalWARS2 
Broad Tumor PortalWARS2
OASIS PortalWARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWARS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch WARS2
DgiDB (Drug Gene Interaction Database)WARS2
DoCM (Curated mutations)WARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WARS2 (select a term)
intoGenWARS2
Cancer3DWARS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604733   
Orphanet
MedgenWARS2
Genetic Testing Registry WARS2
NextProtQ9UGM6 [Medical]
TSGene10352
GENETestsWARS2
Target ValidationWARS2
Huge Navigator WARS2 [HugePedia]
snp3D : Map Gene to Disease10352
BioCentury BCIQWARS2
ClinGenWARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10352
Chemical/Pharm GKB GenePA37341
Clinical trialWARS2
Miscellaneous
canSAR (ICR)WARS2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWARS2
EVEXWARS2
GoPubMedWARS2
iHOPWARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 31 15:48:48 CEST 2017

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