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WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial)

Identity

Alias (NCBI)NEMMLAS
TrpRS
mtTrpRS
HGNC (Hugo) WARS2
HGNC Alias symbTrpRS
HGNC Alias nametryptophan tRNA ligase 2, mitochondrial
LocusID (NCBI) 10352
Atlas_Id 75675
Location 1p12  [Link to chromosome band 1p12]
Location_base_pair Starts at 119031216 and ends at 119140672 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KIAA1549L (11p13) / WARS2 (1p12)VAV3 (1p13.3) / WARS2 (1p12)WARS2 (1p12) / LOXL2 (8p21.3)
WARS2 (1p12) / PHGDH (1p12)WARS2 (1p12) / REG4 (1p12)WARS2 (1p12) / RYR2 (1q43)
WARS2 (1p12) / TPST1 (7q11.21)WARS2 TPST1WARS2 REG4
WARS2 PHGDH

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)WARS2   12730
Cards
Entrez_Gene (NCBI)WARS2    tryptophanyl tRNA synthetase 2, mitochondrial
AliasesNEMMLAS; TrpRS; mtTrpRS
GeneCards (Weizmann)WARS2
Ensembl hg19 (Hinxton)ENSG00000116874 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116874 [Gene_View]  ENSG00000116874 [Sequence]  chr1:119031216-119140672 [Contig_View]  WARS2 [Vega]
ICGC DataPortalENSG00000116874
TCGA cBioPortalWARS2
AceView (NCBI)WARS2
Genatlas (Paris)WARS2
SOURCE (Princeton)WARS2
Genetics Home Reference (NIH)WARS2
Genomic and cartography
GoldenPath hg38 (UCSC)WARS2  -     chr1:119031216-119140672 -  1p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WARS2  -     1p12   [Description]    (hg19-Feb_2009)
GoldenPathWARS2 - 1p12 [CytoView hg19]  WARS2 - 1p12 [CytoView hg38]
ImmunoBaseENSG00000116874
Genome Data Viewer NCBIWARS2 [Mapview hg19]  
OMIM604733   617710   
Gene and transcription
Genbank (Entrez)AJ242739 AK223197 AK296088 AK296799 AK299547
RefSeq transcript (Entrez)NM_001378226 NM_001378227 NM_001378228 NM_001378229 NM_001378230 NM_001378231 NM_015836 NM_201263
Consensus coding sequences : CCDS (NCBI)WARS2
Gene ExpressionWARS2 [ NCBI-GEO ]   WARS2 [ EBI - ARRAY_EXPRESS ]   WARS2 [ SEEK ]   WARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)WARS2 [ Firebrowse - Broad ]
GenevisibleExpression of WARS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10352
GTEX Portal (Tissue expression)WARS2
Human Protein AtlasENSG00000116874-WARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGM6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGM6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGM6
Catalytic activity : Enzyme6.1.1.2 [ Enzyme-Expasy ]   6.1.1.26.1.1.2 [ IntEnz-EBI ]   6.1.1.2 [ BRENDA ]   6.1.1.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UGM6
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ic    Rossmann-like_a/b/a_fold    Trp-tRNA-ligase    Trp-tRNA-ligase_bac-type   
Domain families : Pfam (Sanger)tRNA-synt_1b (PF00579)   
Domain families : Pfam (NCBI)pfam00579   
Conserved Domain (NCBI)WARS2
PDB (RSDB)5EKD   
PDB Europe5EKD   
PDB (PDBSum)5EKD   
PDB (IMB)5EKD   
Structural Biology KnowledgeBase5EKD   
SCOP (Structural Classification of Proteins)5EKD   
CATH (Classification of proteins structures)5EKD   
SuperfamilyQ9UGM6
AlphaFold pdb e-kbQ9UGM6   
Human Protein Atlas [tissue]ENSG00000116874-WARS2 [tissue]
HPRD05295
Protein Interaction databases
DIP (DOE-UCLA)Q9UGM6
IntAct (EBI)Q9UGM6
BioGRIDWARS2
STRING (EMBL)WARS2
ZODIACWARS2
Ontologies - Pathways
QuickGOQ9UGM6
Ontology : AmiGOvasculogenesis  tryptophan-tRNA ligase activity  ATP binding  nucleoplasm  mitochondrion  mitochondrion  mitochondrial matrix  mitochondrial matrix  mitochondrial matrix  plasma membrane  tRNA aminoacylation for protein translation  tryptophanyl-tRNA aminoacylation  mitochondrial tryptophanyl-tRNA aminoacylation  
Ontology : EGO-EBIvasculogenesis  tryptophan-tRNA ligase activity  ATP binding  nucleoplasm  mitochondrion  mitochondrion  mitochondrial matrix  mitochondrial matrix  mitochondrial matrix  plasma membrane  tRNA aminoacylation for protein translation  tryptophanyl-tRNA aminoacylation  mitochondrial tryptophanyl-tRNA aminoacylation  
Pathways : KEGGAminoacyl-tRNA biosynthesis    Tryptophan metabolism   
NDEx NetworkWARS2
Atlas of Cancer Signalling NetworkWARS2
Wikipedia pathwaysWARS2
Orthology - Evolution
OrthoDB10352
GeneTree (enSembl)ENSG00000116874
Phylogenetic Trees/Animal Genes : TreeFamWARS2
Homologs : HomoloGeneWARS2
Homology/Alignments : Family Browser (UCSC)WARS2
Gene fusions - Rearrangements
Fusion : QuiverWARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WARS2
dbVarWARS2
ClinVarWARS2
MonarchWARS2
1000_GenomesWARS2 
Exome Variant ServerWARS2
GNOMAD BrowserENSG00000116874
Varsome BrowserWARS2
ACMGWARS2 variants
VarityQ9UGM6
Genomic Variants (DGV)WARS2 [DGVbeta]
DECIPHERWARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWARS2 
Mutations
ICGC Data PortalWARS2 
TCGA Data PortalWARS2 
Broad Tumor PortalWARS2
OASIS PortalWARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWARS2
Mutations and Diseases : HGMDWARS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaWARS2
DgiDB (Drug Gene Interaction Database)WARS2
DoCM (Curated mutations)WARS2
CIViC (Clinical Interpretations of Variants in Cancer)WARS2
Cancer3DWARS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604733    617710   
Orphanet
DisGeNETWARS2
MedgenWARS2
Genetic Testing Registry WARS2
NextProtQ9UGM6 [Medical]
GENETestsWARS2
Target ValidationWARS2
Huge Navigator WARS2 [HugePedia]
ClinGenWARS2
Clinical trials, drugs, therapy
MyCancerGenomeWARS2
Protein Interactions : CTDWARS2
Pharm GKB GenePA37341
PharosQ9UGM6
Clinical trialWARS2
Miscellaneous
canSAR (ICR)WARS2
HarmonizomeWARS2
DataMed IndexWARS2
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:28:20 CEST 2021

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