WASF1 (WASP family member 1)

2009-08-01  

Identity

HGNC
LOCATION
6q21
LOCUSID
ALIAS
NEDALVS,SCAR1,WAVE,WAVE1
FUSION GENES

Other Information

Locus ID:

NCBI: 8936
MIM: 605035
HGNC: 12732
Ensembl: ENSG00000112290

Variants:

dbSNP: 8936
ClinVar: 8936
TCGA: ENSG00000112290
COSMIC: WASF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112290ENST00000265601Q5SZK4
ENSG00000112290ENST00000359451Q92558
ENSG00000112290ENST00000368938Q5SZK4
ENSG00000112290ENST00000392586Q92558
ENSG00000112290ENST00000392587Q92558
ENSG00000112290ENST00000392588Q92558
ENSG00000112290ENST00000392589Q92558
ENSG00000112290ENST00000419252Q5SZK3
ENSG00000112290ENST00000444391Q5SZK5
ENSG00000112290ENST00000447287Q5SZK3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Regulation of actin cytoskeletonKEGGko04810
Adherens junctionKEGGhsa04520
Regulation of actin cytoskeletonKEGGhsa04810
ShigellosisKEGGhsa05131
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
121815702002Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck.276
176966482007An actin-based wave generator organizes cell motility.164
248193842014Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.132
189958402008Hierarchical regulation of WASP/WAVE proteins.106
185160902008WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.53
218443712011WAVE regulatory complex activation by cooperating GTPases Arf and Rac1.50
182870152008WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines.46
221797762012mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation.37
203684332010Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex.34
232738972013Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.32

Citation

Dessen P

WASF1 (WASP family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51016/wasf1