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WASF1 (WAS protein family member 1)

Identity

Alias_namesWAS protein family
Alias_symbol (synonym)WAVE1
SCAR1
KIAA0269
WAVE
Other alias
HGNC (Hugo) WASF1
LocusID (NCBI) 8936
Atlas_Id 51016
Location 6q21  [Link to chromosome band 6q21]
Location_base_pair Starts at 110099819 and ends at 110180004 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DAP (5p15.2) / WASF1 (6q21)DDX50 (10q22.1) / WASF1 (6q21)FIG4 (6q21) / WASF1 (6q21)
HSPB1 (7q11.23) / WASF1 (6q21)RWDD1 (6q22.1) / WASF1 (6q21)SENP2 (3q27.2) / WASF1 (6q21)
UQCRH (1p34.1) / WASF1 (6q21)FIG4 6q21 / WASF1 6q21RWDD1 6q22.1 / WASF1 6q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WASF1   12732
Cards
Entrez_Gene (NCBI)WASF1  8936  WAS protein family member 1
AliasesSCAR1; WAVE; WAVE1
GeneCards (Weizmann)WASF1
Ensembl hg19 (Hinxton)ENSG00000112290 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112290 [Gene_View]  chr6:110099819-110180004 [Contig_View]  WASF1 [Vega]
ICGC DataPortalENSG00000112290
TCGA cBioPortalWASF1
AceView (NCBI)WASF1
Genatlas (Paris)WASF1
WikiGenes8936
SOURCE (Princeton)WASF1
Genetics Home Reference (NIH)WASF1
Genomic and cartography
GoldenPath hg38 (UCSC)WASF1  -     chr6:110099819-110180004 -  6q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WASF1  -     6q21   [Description]    (hg19-Feb_2009)
EnsemblWASF1 - 6q21 [CytoView hg19]  WASF1 - 6q21 [CytoView hg38]
Mapping of homologs : NCBIWASF1 [Mapview hg19]  WASF1 [Mapview hg38]
OMIM605035   
Gene and transcription
Genbank (Entrez)AF134303 AI928895 AK097838 BC044591 BC068546
RefSeq transcript (Entrez)NM_001024934 NM_001024935 NM_001024936 NM_003931
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WASF1
Cluster EST : UnigeneHs.75850 [ NCBI ]
CGAP (NCI)Hs.75850
Alternative Splicing GalleryENSG00000112290
Gene ExpressionWASF1 [ NCBI-GEO ]   WASF1 [ EBI - ARRAY_EXPRESS ]   WASF1 [ SEEK ]   WASF1 [ MEM ]
Gene Expression Viewer (FireBrowse)WASF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8936
GTEX Portal (Tissue expression)WASF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92558   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92558  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92558
Splice isoforms : SwissVarQ92558
PhosPhoSitePlusQ92558
Domaine pattern : Prosite (Expaxy)WH2 (PS51082)   
Domains : Interpro (EBI)SCAR/WAVE_fam    WH2_dom   
Domain families : Pfam (Sanger)WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam02205   
Domain families : Smart (EMBL)WH2 (SM00246)  
Conserved Domain (NCBI)WASF1
DMDM Disease mutations8936
Blocks (Seattle)WASF1
PDB (SRS)3P8C    4N78   
PDB (PDBSum)3P8C    4N78   
PDB (IMB)3P8C    4N78   
PDB (RSDB)3P8C    4N78   
Structural Biology KnowledgeBase3P8C    4N78   
SCOP (Structural Classification of Proteins)3P8C    4N78   
CATH (Classification of proteins structures)3P8C    4N78   
SuperfamilyQ92558
Human Protein AtlasENSG00000112290
Peptide AtlasQ92558
HPRD05434
IPIIPI00022007   IPI00978063   IPI00646128   IPI00641175   IPI00647483   
Protein Interaction databases
DIP (DOE-UCLA)Q92558
IntAct (EBI)Q92558
FunCoupENSG00000112290
BioGRIDWASF1
STRING (EMBL)WASF1
ZODIACWASF1
Ontologies - Pathways
QuickGOQ92558
Ontology : AmiGOactin binding  protein binding  mitochondrial outer membrane  cytoskeleton  focal adhesion  protein complex assembly  receptor-mediated endocytosis  movement of cell or subcellular component  actin cytoskeleton  Rac protein signal transduction  lamellipodium  actin filament polymerization  SCAR complex  protein complex binding  synapse  Rac GTPase binding  positive regulation of neurotrophin TRK receptor signaling pathway  lamellipodium morphogenesis  dendrite extension  cellular response to brain-derived neurotrophic factor stimulus  positive regulation of Arp2/3 complex-mediated actin nucleation  
Ontology : EGO-EBIactin binding  protein binding  mitochondrial outer membrane  cytoskeleton  focal adhesion  protein complex assembly  receptor-mediated endocytosis  movement of cell or subcellular component  actin cytoskeleton  Rac protein signal transduction  lamellipodium  actin filament polymerization  SCAR complex  protein complex binding  synapse  Rac GTPase binding  positive regulation of neurotrophin TRK receptor signaling pathway  lamellipodium morphogenesis  dendrite extension  cellular response to brain-derived neurotrophic factor stimulus  positive regulation of Arp2/3 complex-mediated actin nucleation  
Pathways : BIOCARTARac 1 cell motility signaling pathway [Genes]    How does salmonella hijack a cell [Genes]    Y branching of actin filaments [Genes]   
Pathways : KEGGAdherens junction    Fc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Shigellosis    Salmonella infection   
NDEx NetworkWASF1
Atlas of Cancer Signalling NetworkWASF1
Wikipedia pathwaysWASF1
Orthology - Evolution
OrthoDB8936
GeneTree (enSembl)ENSG00000112290
Phylogenetic Trees/Animal Genes : TreeFamWASF1
HOVERGENQ92558
HOGENOMQ92558
Homologs : HomoloGeneWASF1
Homology/Alignments : Family Browser (UCSC)WASF1
Gene fusions - Rearrangements
Fusion : MitelmanRWDD1/WASF1 [6q22.1/6q21]  [t(6;6)(q21;q22)]  
Fusion: TCGAFIG4 6q21 WASF1 6q21 BRCA
Fusion: TCGARWDD1 6q22.1 WASF1 6q21 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWASF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WASF1
dbVarWASF1
ClinVarWASF1
1000_GenomesWASF1 
Exome Variant ServerWASF1
ExAC (Exome Aggregation Consortium)WASF1 (select the gene name)
Genetic variants : HAPMAP8936
Genomic Variants (DGV)WASF1 [DGVbeta]
DECIPHERWASF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWASF1 
Mutations
ICGC Data PortalWASF1 
TCGA Data PortalWASF1 
Broad Tumor PortalWASF1
OASIS PortalWASF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWASF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWASF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WASF1
DgiDB (Drug Gene Interaction Database)WASF1
DoCM (Curated mutations)WASF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WASF1 (select a term)
intoGenWASF1
Cancer3DWASF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605035   
Orphanet
MedgenWASF1
Genetic Testing Registry WASF1
NextProtQ92558 [Medical]
TSGene8936
GENETestsWASF1
Target ValidationWASF1
Huge Navigator WASF1 [HugePedia]
snp3D : Map Gene to Disease8936
BioCentury BCIQWASF1
ClinGenWASF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8936
Chemical/Pharm GKB GenePA37343
Clinical trialWASF1
Miscellaneous
canSAR (ICR)WASF1 (select the gene name)
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWASF1
EVEXWASF1
GoPubMedWASF1
iHOPWASF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:11:38 CEST 2017

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