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WASF2 (WAS protein family member 2)

Identity

Alias_namesWAS protein family
Alias_symbol (synonym)WAVE2
SCAR2
Other aliasIMD2
WASF4
dJ393P12.2
HGNC (Hugo) WASF2
LocusID (NCBI) 10163
Atlas_Id 49745
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 27730730 and ends at 27816698 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CTIF (18q21.1) / WASF2 (1p36.11)RACK1 (5q35.3) / WASF2 (1p36.11)RBM39 (20q11.22) / WASF2 (1p36.11)
SMARCB1 (22q11.23) / WASF2 (1p36.11)TRIB3 (20p13) / WASF2 (1p36.11)WASF2 (1p36.11) / AHDC1 (1p36.11)
WASF2 (1p36.11) / FAM65B (6p22.3)WASF2 (1p36.11) / FGR (1p36.11)WASF2 (1p36.11) / KHDRBS1 (1p35.1)
CTIF 18q21.1 / WASF2 1p36.11WASF2 1p36.11 / AHDC1 1p36.11WASF2 1p36.11 / FAM65B 6p22.3
WASF2 1p36.11 / FGR 1p36.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Soft tissue tumors: an overview


External links

Nomenclature
HGNC (Hugo)WASF2   12733
Cards
Entrez_Gene (NCBI)WASF2  10163  WAS protein family member 2
AliasesIMD2; SCAR2; WASF4; WAVE2; 
dJ393P12.2
GeneCards (Weizmann)WASF2
Ensembl hg19 (Hinxton)ENSG00000158195 [Gene_View]  chr1:27730730-27816698 [Contig_View]  WASF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000158195 [Gene_View]  chr1:27730730-27816698 [Contig_View]  WASF2 [Vega]
ICGC DataPortalENSG00000158195
TCGA cBioPortalWASF2
AceView (NCBI)WASF2
Genatlas (Paris)WASF2
WikiGenes10163
SOURCE (Princeton)WASF2
Genetics Home Reference (NIH)WASF2
Genomic and cartography
GoldenPath hg19 (UCSC)WASF2  -     chr1:27730730-27816698 -  1p36.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WASF2  -     1p36.11   [Description]    (hg38-Dec_2013)
EnsemblWASF2 - 1p36.11 [CytoView hg19]  WASF2 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBIWASF2 [Mapview hg19]  WASF2 [Mapview hg38]
OMIM605875   
Gene and transcription
Genbank (Entrez)AA736923 AB026542 AJ431612 AK024540 AK025566
RefSeq transcript (Entrez)NM_001201404 NM_006990
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)WASF2
Cluster EST : UnigeneHs.512079 [ NCBI ]
CGAP (NCI)Hs.512079
Alternative Splicing GalleryENSG00000158195
Gene ExpressionWASF2 [ NCBI-GEO ]   WASF2 [ EBI - ARRAY_EXPRESS ]   WASF2 [ SEEK ]   WASF2 [ MEM ]
Gene Expression Viewer (FireBrowse)WASF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10163
GTEX Portal (Tissue expression)WASF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6W5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6W5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6W5
Splice isoforms : SwissVarQ9Y6W5
PhosPhoSitePlusQ9Y6W5
Domaine pattern : Prosite (Expaxy)WH2 (PS51082)   
Domains : Interpro (EBI)SCAR/WAVE_fam    WH2_dom   
Domain families : Pfam (Sanger)WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam02205   
Domain families : Smart (EMBL)WH2 (SM00246)  
Conserved Domain (NCBI)WASF2
DMDM Disease mutations10163
Blocks (Seattle)WASF2
PDB (SRS)2A40   
PDB (PDBSum)2A40   
PDB (IMB)2A40   
PDB (RSDB)2A40   
Structural Biology KnowledgeBase2A40   
SCOP (Structural Classification of Proteins)2A40   
CATH (Classification of proteins structures)2A40   
SuperfamilyQ9Y6W5
Human Protein AtlasENSG00000158195
Peptide AtlasQ9Y6W5
HPRD05796
IPIIPI00472164   IPI00976656   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6W5
IntAct (EBI)Q9Y6W5
FunCoupENSG00000158195
BioGRIDWASF2
STRING (EMBL)WASF2
ZODIACWASF2
Ontologies - Pathways
QuickGOQ9Y6W5
Ontology : AmiGOangiogenesis  ameboidal-type cell migration  ruffle  actin binding  protein binding  intracellular  early endosome  cytosol  cell-cell junction  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  positive regulation of lamellipodium assembly  actin cytoskeleton  viral process  Rac protein signal transduction  lamellipodium  lamellipodium assembly  actin cytoskeleton organization  actin filament-based movement  SCAR complex  protein complex binding  protein complex binding  megakaryocyte development  Fc-gamma receptor signaling pathway involved in phagocytosis  vascular endothelial growth factor receptor signaling pathway  negative regulation of stress fiber assembly  extracellular exosome  lamellipodium morphogenesis  
Ontology : EGO-EBIangiogenesis  ameboidal-type cell migration  ruffle  actin binding  protein binding  intracellular  early endosome  cytosol  cell-cell junction  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  positive regulation of lamellipodium assembly  actin cytoskeleton  viral process  Rac protein signal transduction  lamellipodium  lamellipodium assembly  actin cytoskeleton organization  actin filament-based movement  SCAR complex  protein complex binding  protein complex binding  megakaryocyte development  Fc-gamma receptor signaling pathway involved in phagocytosis  vascular endothelial growth factor receptor signaling pathway  negative regulation of stress fiber assembly  extracellular exosome  lamellipodium morphogenesis  
Pathways : BIOCARTAY branching of actin filaments [Genes]   
Pathways : KEGGAdherens junction    Fc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Shigellosis    Salmonella infection   
NDEx NetworkWASF2
Atlas of Cancer Signalling NetworkWASF2
Wikipedia pathwaysWASF2
Orthology - Evolution
OrthoDB10163
GeneTree (enSembl)ENSG00000158195
Phylogenetic Trees/Animal Genes : TreeFamWASF2
HOVERGENQ9Y6W5
HOGENOMQ9Y6W5
Homologs : HomoloGeneWASF2
Homology/Alignments : Family Browser (UCSC)WASF2
Gene fusions - Rearrangements
Fusion : MitelmanCTIF/WASF2 [18q21.1/1p36.11]  [t(1;18)(p36;q21)]  
Fusion : MitelmanSMARCB1/WASF2 [22q11.23/1p36.11]  [t(1;22)(p36;q11)]  
Fusion : MitelmanWASF2/AHDC1 [1p36.11/1p36.11]  [t(1;1)(p36;p36)]  
Fusion : MitelmanWASF2/FAM65B [1p36.11/6p22.3]  [t(1;6)(p36;p22)]  
Fusion : MitelmanWASF2/FGR [1p36.11/1p36.11]  [t(1;1)(p36;p36)]  
Fusion: TCGACTIF 18q21.1 WASF2 1p36.11 BRCA
Fusion: TCGAWASF2 1p36.11 AHDC1 1p36.11 HNSC LUSC
Fusion: TCGAWASF2 1p36.11 FAM65B 6p22.3 LUSC
Fusion: TCGAWASF2 1p36.11 FGR 1p36.11 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWASF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WASF2
dbVarWASF2
ClinVarWASF2
1000_GenomesWASF2 
Exome Variant ServerWASF2
ExAC (Exome Aggregation Consortium)WASF2 (select the gene name)
Genetic variants : HAPMAP10163
Genomic Variants (DGV)WASF2 [DGVbeta]
DECIPHER (Syndromes)1:27730730-27816698  ENSG00000158195
CONAN: Copy Number AnalysisWASF2 
Mutations
ICGC Data PortalWASF2 
TCGA Data PortalWASF2 
Broad Tumor PortalWASF2
OASIS PortalWASF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWASF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWASF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WASF2
DgiDB (Drug Gene Interaction Database)WASF2
DoCM (Curated mutations)WASF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WASF2 (select a term)
intoGenWASF2
Cancer3DWASF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605875   
Orphanet
MedgenWASF2
Genetic Testing Registry WASF2
NextProtQ9Y6W5 [Medical]
TSGene10163
GENETestsWASF2
Huge Navigator WASF2 [HugePedia]
snp3D : Map Gene to Disease10163
BioCentury BCIQWASF2
ClinGenWASF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10163
Chemical/Pharm GKB GenePA37344
Clinical trialWASF2
Miscellaneous
canSAR (ICR)WASF2 (select the gene name)
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWASF2
EVEXWASF2
GoPubMedWASF2
iHOPWASF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:24:54 CEST 2017

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