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WASL (Wiskott-Aldrich syndrome like)

Identity

Alias_namesWiskott-Aldrich syndrome-like
Alias_symbol (synonym)N-WASP
NWASP
WASPB
HGNC (Hugo) WASL
LocusID (NCBI) 8976
Atlas_Id 42803
Location 7q31.32  [Link to chromosome band 7q31]
Location_base_pair Starts at 123321981 and ends at 123389125 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
WASL (7q31.32) / RALBP1 (18p11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WASL   12735
Cards
Entrez_Gene (NCBI)WASL  8976  Wiskott-Aldrich syndrome like
AliasesN-WASP; NWASP; WASPB
GeneCards (Weizmann)WASL
Ensembl hg19 (Hinxton)ENSG00000106299 [Gene_View]  chr7:123321981-123389125 [Contig_View]  WASL [Vega]
Ensembl hg38 (Hinxton)ENSG00000106299 [Gene_View]  chr7:123321981-123389125 [Contig_View]  WASL [Vega]
ICGC DataPortalENSG00000106299
TCGA cBioPortalWASL
AceView (NCBI)WASL
Genatlas (Paris)WASL
WikiGenes8976
SOURCE (Princeton)WASL
Genetics Home Reference (NIH)WASL
Genomic and cartography
GoldenPath hg19 (UCSC)WASL  -     chr7:123321981-123389125 -  7q31.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WASL  -     7q31.32   [Description]    (hg38-Dec_2013)
EnsemblWASL - 7q31.32 [CytoView hg19]  WASL - 7q31.32 [CytoView hg38]
Mapping of homologs : NCBIWASL [Mapview hg19]  WASL [Mapview hg38]
OMIM605056   
Gene and transcription
Genbank (Entrez)AK023554 AK131016 AK289795 AM295156 BC013776
RefSeq transcript (Entrez)NM_003941
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)WASL
Cluster EST : UnigeneHs.731519 [ NCBI ]
CGAP (NCI)Hs.731519
Alternative Splicing GalleryENSG00000106299
Gene ExpressionWASL [ NCBI-GEO ]   WASL [ EBI - ARRAY_EXPRESS ]   WASL [ SEEK ]   WASL [ MEM ]
Gene Expression Viewer (FireBrowse)WASL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8976
GTEX Portal (Tissue expression)WASL
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00401   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00401  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00401
Splice isoforms : SwissVarO00401
PhosPhoSitePlusO00401
Domaine pattern : Prosite (Expaxy)CRIB (PS50108)    WH1 (PS50229)    WH2 (PS51082)   
Domains : Interpro (EBI)CRIB_dom    N-WASP    PH_dom-like    WASP_C    WH1/EVH1_dom    WH2_dom   
Domain families : Pfam (Sanger)PBD (PF00786)    WH1 (PF00568)    WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam00786    pfam00568    pfam02205   
Domain families : Smart (EMBL)PBD (SM00285)  WH1 (SM00461)  WH2 (SM00246)  
Conserved Domain (NCBI)WASL
DMDM Disease mutations8976
Blocks (Seattle)WASL
PDB (SRS)2FF3    2LNH    2VCP    4CC2    4CC7   
PDB (PDBSum)2FF3    2LNH    2VCP    4CC2    4CC7   
PDB (IMB)2FF3    2LNH    2VCP    4CC2    4CC7   
PDB (RSDB)2FF3    2LNH    2VCP    4CC2    4CC7   
Structural Biology KnowledgeBase2FF3    2LNH    2VCP    4CC2    4CC7   
SCOP (Structural Classification of Proteins)2FF3    2LNH    2VCP    4CC2    4CC7   
CATH (Classification of proteins structures)2FF3    2LNH    2VCP    4CC2    4CC7   
SuperfamilyO00401
Human Protein AtlasENSG00000106299
Peptide AtlasO00401
HPRD05448
IPIIPI00011676   IPI01014145   IPI00945907   
Protein Interaction databases
DIP (DOE-UCLA)O00401
IntAct (EBI)O00401
FunCoupENSG00000106299
BioGRIDWASL
STRING (EMBL)WASL
ZODIACWASL
Ontologies - Pathways
QuickGOO00401
Ontology : AmiGOGolgi membrane  actin binding  protein binding  nucleus  cytosol  cytosol  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein complex assembly  membrane budding  movement of cell or subcellular component  mitotic nuclear division  actin polymerization or depolymerization  response to bacterium  actin cytoskeleton  cytoplasmic, membrane-bounded vesicle  vesicle organization  lamellipodium  vesicle transport along actin filament  actin cap  endocytic vesicle membrane  GTPase regulator activity  regulation of protein localization  cellular protein complex localization  Fc-gamma receptor signaling pathway involved in phagocytosis  ephrin receptor signaling pathway  regulation of nitric-oxide synthase activity  cell division  positive regulation of filopodium assembly  spindle localization  extracellular exosome  negative regulation of membrane tubulation  positive regulation of clathrin-mediated endocytosis  negative regulation of lymphocyte migration  positive regulation of Arp2/3 complex-mediated actin nucleation  
Ontology : EGO-EBIGolgi membrane  actin binding  protein binding  nucleus  cytosol  cytosol  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein complex assembly  membrane budding  movement of cell or subcellular component  mitotic nuclear division  actin polymerization or depolymerization  response to bacterium  actin cytoskeleton  cytoplasmic, membrane-bounded vesicle  vesicle organization  lamellipodium  vesicle transport along actin filament  actin cap  endocytic vesicle membrane  GTPase regulator activity  regulation of protein localization  cellular protein complex localization  Fc-gamma receptor signaling pathway involved in phagocytosis  ephrin receptor signaling pathway  regulation of nitric-oxide synthase activity  cell division  positive regulation of filopodium assembly  spindle localization  extracellular exosome  negative regulation of membrane tubulation  positive regulation of clathrin-mediated endocytosis  negative regulation of lymphocyte migration  positive regulation of Arp2/3 complex-mediated actin nucleation  
Pathways : BIOCARTARole of PI3K subunit p85 in regulation of Actin Organization and Cell Migration [Genes]    Y branching of actin filaments [Genes]    How does salmonella hijack a cell [Genes]   
Pathways : KEGGChemokine signaling pathway    Adherens junction    Fc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Salmonella infection   
NDEx NetworkWASL
Atlas of Cancer Signalling NetworkWASL
Wikipedia pathwaysWASL
Orthology - Evolution
OrthoDB8976
GeneTree (enSembl)ENSG00000106299
Phylogenetic Trees/Animal Genes : TreeFamWASL
HOVERGENO00401
HOGENOMO00401
Homologs : HomoloGeneWASL
Homology/Alignments : Family Browser (UCSC)WASL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWASL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WASL
dbVarWASL
ClinVarWASL
1000_GenomesWASL 
Exome Variant ServerWASL
ExAC (Exome Aggregation Consortium)WASL (select the gene name)
Genetic variants : HAPMAP8976
Genomic Variants (DGV)WASL [DGVbeta]
DECIPHER (Syndromes)7:123321981-123389125  ENSG00000106299
CONAN: Copy Number AnalysisWASL 
Mutations
ICGC Data PortalWASL 
TCGA Data PortalWASL 
Broad Tumor PortalWASL
OASIS PortalWASL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWASL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWASL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WASL
DgiDB (Drug Gene Interaction Database)WASL
DoCM (Curated mutations)WASL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WASL (select a term)
intoGenWASL
Cancer3DWASL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605056   
Orphanet
MedgenWASL
Genetic Testing Registry WASL
NextProtO00401 [Medical]
TSGene8976
GENETestsWASL
Huge Navigator WASL [HugePedia]
snp3D : Map Gene to Disease8976
BioCentury BCIQWASL
ClinGenWASL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8976
Chemical/Pharm GKB GenePA37346
Clinical trialWASL
Miscellaneous
canSAR (ICR)WASL (select the gene name)
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWASL
EVEXWASL
GoPubMedWASL
iHOPWASL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:55:43 CET 2016

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