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WASL (Wiskott-Aldrich syndrome-like)

Identity

Other namesN-WASP
NWASP
WASPB
HGNC (Hugo) WASL
LocusID (NCBI) 8976
Atlas_Id 42803
Location 7q31.32
Location_base_pair Starts at 123321981 and ends at 123389125 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)WASL   12735
Cards
Entrez_Gene (NCBI)WASL  8976  Wiskott-Aldrich syndrome-like
GeneCards (Weizmann)WASL
Ensembl hg19 (Hinxton)ENSG00000106299 [Gene_View]  chr7:123321981-123389125 [Contig_View]  WASL [Vega]
Ensembl hg38 (Hinxton)ENSG00000106299 [Gene_View]  chr7:123321981-123389125 [Contig_View]  WASL [Vega]
ICGC DataPortalENSG00000106299
TCGA cBioPortalWASL
AceView (NCBI)WASL
Genatlas (Paris)WASL
WikiGenes8976
SOURCE (Princeton)WASL
Genomic and cartography
GoldenPath hg19 (UCSC)WASL  -     chr7:123321981-123389125 -  7q31.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WASL  -     7q31.32   [Description]    (hg38-Dec_2013)
EnsemblWASL - 7q31.32 [CytoView hg19]  WASL - 7q31.32 [CytoView hg38]
Mapping of homologs : NCBIWASL [Mapview hg19]  WASL [Mapview hg38]
OMIM605056   
Gene and transcription
Genbank (Entrez)AK023554 AK131016 AK289795 AM295156 BC013776
RefSeq transcript (Entrez)NM_003941
RefSeq genomic (Entrez)NC_000007 NC_018918 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)WASL
Cluster EST : UnigeneHs.731519 [ NCBI ]
CGAP (NCI)Hs.731519
Alternative Splicing : Fast-db (Paris)GSHG0028538
Alternative Splicing GalleryENSG00000106299
Gene ExpressionWASL [ NCBI-GEO ]     WASL [ SEEK ]   WASL [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00401 (Uniprot)
NextProtO00401  [Medical]  [Publications]
With graphics : InterProO00401
Splice isoforms : SwissVarO00401 (Swissvar)
Domaine pattern : Prosite (Expaxy)CRIB (PS50108)    WH1 (PS50229)    WH2 (PS51082)   
Domains : Interpro (EBI)CRIB_dom    N-WASP    PH_like_dom    WASP_C    WH1/EVH1_dom    WH2_dom   
Related proteins : CluSTrO00401
Domain families : Pfam (Sanger)PBD (PF00786)    WH1 (PF00568)    WH2 (PF02205)   
Domain families : Pfam (NCBI)pfam00786    pfam00568    pfam02205   
Domain families : Smart (EMBL)PBD (SM00285)  WH1 (SM00461)  WH2 (SM00246)  
DMDM Disease mutations8976
Blocks (Seattle)O00401
PDB (SRS)2FF3    2LNH    2VCP    4CC2    4CC7   
PDB (PDBSum)2FF3    2LNH    2VCP    4CC2    4CC7   
PDB (IMB)2FF3    2LNH    2VCP    4CC2    4CC7   
PDB (RSDB)2FF3    2LNH    2VCP    4CC2    4CC7   
Human Protein AtlasENSG00000106299
Peptide AtlasO00401
HPRD05448
IPIIPI00011676   IPI01014145   IPI00945907   
Protein Interaction databases
DIP (DOE-UCLA)O00401
IntAct (EBI)O00401
FunCoupENSG00000106299
BioGRIDWASL
IntegromeDBWASL
STRING (EMBL)WASL
Ontologies - Pathways
QuickGOO00401
Ontology : AmiGOactin binding  protein binding  nucleus  cytosol  cytosol  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein complex assembly  membrane budding  movement of cell or subcellular component  mitotic nuclear division  small GTPase mediated signal transduction  axon guidance  actin polymerization or depolymerization  response to bacterium  actin cytoskeleton  cytoplasmic membrane-bounded vesicle  vesicle organization  lamellipodium  vesicle transport along actin filament  actin cap  endocytic vesicle membrane  GTPase regulator activity  regulation of protein localization  cellular protein complex localization  Fc-gamma receptor signaling pathway involved in phagocytosis  small molecule metabolic process  innate immune response  nitric oxide metabolic process  ephrin receptor signaling pathway  regulation of nitric-oxide synthase activity  cell division  positive regulation of filopodium assembly  spindle localization  extracellular exosome  negative regulation of membrane tubulation  positive regulation of clathrin-mediated endocytosis  negative regulation of lymphocyte migration  positive regulation of Arp2/3 complex-mediated actin nucleation  
Ontology : EGO-EBIactin binding  protein binding  nucleus  cytosol  cytosol  plasma membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  protein complex assembly  membrane budding  movement of cell or subcellular component  mitotic nuclear division  small GTPase mediated signal transduction  axon guidance  actin polymerization or depolymerization  response to bacterium  actin cytoskeleton  cytoplasmic membrane-bounded vesicle  vesicle organization  lamellipodium  vesicle transport along actin filament  actin cap  endocytic vesicle membrane  GTPase regulator activity  regulation of protein localization  cellular protein complex localization  Fc-gamma receptor signaling pathway involved in phagocytosis  small molecule metabolic process  innate immune response  nitric oxide metabolic process  ephrin receptor signaling pathway  regulation of nitric-oxide synthase activity  cell division  positive regulation of filopodium assembly  spindle localization  extracellular exosome  negative regulation of membrane tubulation  positive regulation of clathrin-mediated endocytosis  negative regulation of lymphocyte migration  positive regulation of Arp2/3 complex-mediated actin nucleation  
Pathways : BIOCARTARole of PI3K subunit p85 in regulation of Actin Organization and Cell Migration [Genes]    Y branching of actin filaments [Genes]    How does salmonella hijack a cell [Genes]   
Pathways : KEGGChemokine signaling pathway    Adherens junction    Fc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Bacterial invasion of epithelial cells    Pathogenic Escherichia coli infection    Shigellosis    Salmonella infection   
Protein Interaction DatabaseWASL
DoCM (Curated mutations)WASL
Wikipedia pathwaysWASL
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerWASL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WASL
dbVarWASL
ClinVarWASL
1000_GenomesWASL 
Exome Variant ServerWASL
SNP (GeneSNP Utah)WASL
SNP : HGBaseWASL
Genetic variants : HAPMAPWASL
Genomic Variants (DGV)WASL [DGVbeta]
Mutations
ICGC Data PortalWASL 
TCGA Data PortalWASL 
Tumor PortalWASL
Somatic Mutations in Cancer : COSMICWASL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:123321981-123389125
CONAN: Copy Number AnalysisWASL 
Mutations and Diseases : HGMDWASL
OMIM605056   
MedgenWASL
NextProtO00401 [Medical]
GENETestsWASL
Disease Genetic AssociationWASL
Huge Navigator WASL [HugePedia]  WASL [HugeCancerGEM]
snp3D : Map Gene to Disease8976
DGIdb (Drug Gene Interaction db)WASL
BioCentury BCIQWASL
General knowledge
Homologs : HomoloGeneWASL
Homology/Alignments : Family Browser (UCSC)WASL
Phylogenetic Trees/Animal Genes : TreeFamWASL
Chemical/Protein Interactions : CTD8976
Chemical/Pharm GKB GenePA37346
Clinical trialWASL
Cancer Resource (Charite)ENSG00000106299
Other databases
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
CoreMineWASL
GoPubMedWASL
iHOPWASL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 12:30:28 CEST 2015

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