WBP2 (WW domain binding protein 2)

2017-08-01  

Identity

HGNC
WBP2
LOCATION
17q25.1
LOCUSID
23558
ALIAS
DFNB107,GRAMD6,WBP-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23558
MIM: 606962
HGNC: 12738
Ensembl: ENSG00000132471

Variants:

dbSNP: 23558
ClinVar: 23558
TCGA: ENSG00000132471
COSMIC: WBP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132471ENST00000254806Q969T9
ENSG00000132471ENST00000254806A0A024R8L1
ENSG00000132471ENST00000433525Q969T9
ENSG00000132471ENST00000585462A6NG10
ENSG00000132471ENST00000586257K7EIK1
ENSG00000132471ENST00000587374K7EIN1
ENSG00000132471ENST00000588373K7EJ75
ENSG00000132471ENST00000589642K7ESN4
ENSG00000132471ENST00000590221K7EMC9
ENSG00000132471ENST00000591399Q969T9
ENSG00000132471ENST00000591399A0A024R8L1
ENSG00000132471ENST00000591831K7ENL2
ENSG00000132471ENST00000593002K7EIJ0
ENSG00000132471ENST00000626827K7ENL2

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
209724592011WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ.44
167725332006WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors.27
275780032016Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.20
283324982017A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.16
268819682016Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing.14
219810242011Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.13
294970312018WW domain-binding protein 2 acts as an oncogene by modulating the activity of the glycolytic enzyme ENO1 in glioma.12
232333542013Molecular mechanism of WW-domain binding protein-2 coactivation function in estrogen receptor signaling.8
283913532017WBP2 modulates G1/S transition in ER+ breast cancer cells and is a direct target of miR-206.6
299375442018Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription.5

Citation

Dessen P

WBP2 (WW domain binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57045/wbp2