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WDFY2 (WD repeat and FYVE domain containing 2)

Identity

Alias_namesWD40 and FYVE domain containing 2
Alias_symbol (synonym)ZFYVE22
Other aliasPROF
WDF2
HGNC (Hugo) WDFY2
LocusID (NCBI) 115825
Atlas_Id 55005
Location 13q14.3  [Link to chromosome band 13q14]
Location_base_pair Starts at 52158484 and ends at 52336171 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDKN2D (19p13.2) / WDFY2 (13q14.3)WDFY2 (13q14.3) / S1PR5 (19p13.2)WDFY2 (13q14.3) / SERPINE3 (13q14.3)
CDKN2D 19p13.2 / WDFY2 13q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WDFY2   20482
Cards
Entrez_Gene (NCBI)WDFY2  115825  WD repeat and FYVE domain containing 2
AliasesPROF; WDF2; ZFYVE22
GeneCards (Weizmann)WDFY2
Ensembl hg19 (Hinxton)ENSG00000139668 [Gene_View]  chr13:52158484-52336171 [Contig_View]  WDFY2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000139668 [Gene_View]  chr13:52158484-52336171 [Contig_View]  WDFY2 [Vega]
ICGC DataPortalENSG00000139668
TCGA cBioPortalWDFY2
AceView (NCBI)WDFY2
Genatlas (Paris)WDFY2
WikiGenes115825
SOURCE (Princeton)WDFY2
Genetics Home Reference (NIH)WDFY2
Genomic and cartography
GoldenPath hg19 (UCSC)WDFY2  -     chr13:52158484-52336171 +  13q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)WDFY2  -     13q14.3   [Description]    (hg38-Dec_2013)
EnsemblWDFY2 - 13q14.3 [CytoView hg19]  WDFY2 - 13q14.3 [CytoView hg38]
Mapping of homologs : NCBIWDFY2 [Mapview hg19]  WDFY2 [Mapview hg38]
OMIM610418   
Gene and transcription
Genbank (Entrez)AF411978 AK054833 AK058149 AK093224 AK095358
RefSeq transcript (Entrez)NM_052950
RefSeq genomic (Entrez)NC_000013 NC_018924 NT_024524 NW_004929388
Consensus coding sequences : CCDS (NCBI)WDFY2
Cluster EST : UnigeneHs.208550 [ NCBI ]
CGAP (NCI)Hs.208550
Alternative Splicing GalleryENSG00000139668
Gene ExpressionWDFY2 [ NCBI-GEO ]   WDFY2 [ EBI - ARRAY_EXPRESS ]   WDFY2 [ SEEK ]   WDFY2 [ MEM ]
Gene Expression Viewer (FireBrowse)WDFY2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115825
GTEX Portal (Tissue expression)WDFY2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96P53   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96P53  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96P53
Splice isoforms : SwissVarQ96P53
PhosPhoSitePlusQ96P53
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam01363    pfam00400   
Domain families : Smart (EMBL)FYVE (SM00064)  WD40 (SM00320)  
Conserved Domain (NCBI)WDFY2
DMDM Disease mutations115825
Blocks (Seattle)WDFY2
SuperfamilyQ96P53
Human Protein AtlasENSG00000139668
Peptide AtlasQ96P53
HPRD18294
IPIIPI00073577   
Protein Interaction databases
DIP (DOE-UCLA)Q96P53
IntAct (EBI)Q96P53
FunCoupENSG00000139668
BioGRIDWDFY2
STRING (EMBL)WDFY2
ZODIACWDFY2
Ontologies - Pathways
QuickGOQ96P53
Ontology : AmiGOpositive regulation of protein phosphorylation  protein binding  early endosome  vesicle  positive regulation of fat cell differentiation  metal ion binding  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  protein binding  early endosome  vesicle  positive regulation of fat cell differentiation  metal ion binding  
NDEx NetworkWDFY2
Atlas of Cancer Signalling NetworkWDFY2
Wikipedia pathwaysWDFY2
Orthology - Evolution
OrthoDB115825
GeneTree (enSembl)ENSG00000139668
Phylogenetic Trees/Animal Genes : TreeFamWDFY2
HOVERGENQ96P53
HOGENOMQ96P53
Homologs : HomoloGeneWDFY2
Homology/Alignments : Family Browser (UCSC)WDFY2
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2D/WDFY2 [19p13.2/13q14.3]  [t(13;19)(q14;p13)]  
Fusion : MitelmanWDFY2/S1PR5 [13q14.3/19p13.2]  [t(13;19)(q14;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDFY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDFY2
dbVarWDFY2
ClinVarWDFY2
1000_GenomesWDFY2 
Exome Variant ServerWDFY2
ExAC (Exome Aggregation Consortium)WDFY2 (select the gene name)
Genetic variants : HAPMAP115825
Genomic Variants (DGV)WDFY2 [DGVbeta]
DECIPHER (Syndromes)13:52158484-52336171  ENSG00000139668
CONAN: Copy Number AnalysisWDFY2 
Mutations
ICGC Data PortalWDFY2 
TCGA Data PortalWDFY2 
Broad Tumor PortalWDFY2
OASIS PortalWDFY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDFY2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDFY2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDFY2
DgiDB (Drug Gene Interaction Database)WDFY2
DoCM (Curated mutations)WDFY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDFY2 (select a term)
intoGenWDFY2
Cancer3DWDFY2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610418   
Orphanet
MedgenWDFY2
Genetic Testing Registry WDFY2
NextProtQ96P53 [Medical]
TSGene115825
GENETestsWDFY2
Huge Navigator WDFY2 [HugePedia]
snp3D : Map Gene to Disease115825
BioCentury BCIQWDFY2
ClinGenWDFY2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115825
Chemical/Pharm GKB GenePA134870231
Clinical trialWDFY2
Miscellaneous
canSAR (ICR)WDFY2 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDFY2
EVEXWDFY2
GoPubMedWDFY2
iHOPWDFY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:56 CEST 2017

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