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WDFY2 (WD repeat and FYVE domain containing 2)

Identity

Alias (NCBI)PROF
WDF2
ZFYVE22
HGNC (Hugo) WDFY2
HGNC Alias symbZFYVE22
HGNC Previous nameWD40 and FYVE domain containing 2
LocusID (NCBI) 115825
Atlas_Id 55005
Location 13q14.3  [Link to chromosome band 13q14]
Location_base_pair Starts at 51584462 and ends at 51767709 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKN2D (19p13.2) / WDFY2 (13q14.3)WDFY2 (13q14.3) / S1PR5 (19p13.2)WDFY2 (13q14.3) / SERPINE3 (13q14.3)
CDKN2D 19p13.2 / WDFY2 13q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(13;13)(q14;q14) RB1/WDFY2


External links

Nomenclature
HGNC (Hugo)WDFY2   20482
Cards
Entrez_Gene (NCBI)WDFY2    WD repeat and FYVE domain containing 2
AliasesPROF; WDF2; ZFYVE22
GeneCards (Weizmann)WDFY2
Ensembl hg19 (Hinxton)ENSG00000139668 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139668 [Gene_View]  ENSG00000139668 [Sequence]  chr13:51584462-51767709 [Contig_View]  WDFY2 [Vega]
ICGC DataPortalENSG00000139668
TCGA cBioPortalWDFY2
AceView (NCBI)WDFY2
Genatlas (Paris)WDFY2
SOURCE (Princeton)WDFY2
Genetics Home Reference (NIH)WDFY2
Genomic and cartography
GoldenPath hg38 (UCSC)WDFY2  -     chr13:51584462-51767709 +  13q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDFY2  -     13q14.3   [Description]    (hg19-Feb_2009)
GoldenPathWDFY2 - 13q14.3 [CytoView hg19]  WDFY2 - 13q14.3 [CytoView hg38]
ImmunoBaseENSG00000139668
genome Data Viewer NCBIWDFY2 [Mapview hg19]  
OMIM610418   
Gene and transcription
Genbank (Entrez)AF411978 AK054833 AK058149 AK093224 AK095358
RefSeq transcript (Entrez)NM_052950
Consensus coding sequences : CCDS (NCBI)WDFY2
Alternative Splicing GalleryENSG00000139668
Gene ExpressionWDFY2 [ NCBI-GEO ]   WDFY2 [ EBI - ARRAY_EXPRESS ]   WDFY2 [ SEEK ]   WDFY2 [ MEM ]
Gene Expression Viewer (FireBrowse)WDFY2 [ Firebrowse - Broad ]
GenevisibleExpression of WDFY2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115825
GTEX Portal (Tissue expression)WDFY2
Human Protein AtlasENSG00000139668-WDFY2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96P53   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96P53  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96P53
PhosPhoSitePlusQ96P53
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf    WDFY1/WDFY2    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)FYVE (PF01363)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam01363    pfam00400   
Domain families : Smart (EMBL)FYVE (SM00064)  WD40 (SM00320)  
Conserved Domain (NCBI)WDFY2
SuperfamilyQ96P53
AlphaFold pdb e-kbQ96P53   
Human Protein Atlas [tissue]ENSG00000139668-WDFY2 [tissue]
HPRD18294
Protein Interaction databases
DIP (DOE-UCLA)Q96P53
IntAct (EBI)Q96P53
BioGRIDWDFY2
STRING (EMBL)WDFY2
ZODIACWDFY2
Ontologies - Pathways
QuickGOQ96P53
Ontology : AmiGOpositive regulation of protein phosphorylation  protein binding  early endosome  vesicle  intracellular membrane-bounded organelle  positive regulation of fat cell differentiation  metal ion binding  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  protein binding  early endosome  vesicle  intracellular membrane-bounded organelle  positive regulation of fat cell differentiation  metal ion binding  
NDEx NetworkWDFY2
Atlas of Cancer Signalling NetworkWDFY2
Wikipedia pathwaysWDFY2
Orthology - Evolution
OrthoDB115825
GeneTree (enSembl)ENSG00000139668
Phylogenetic Trees/Animal Genes : TreeFamWDFY2
Homologs : HomoloGeneWDFY2
Homology/Alignments : Family Browser (UCSC)WDFY2
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2D/WDFY2 [19p13.2/13q14.3]  
Fusion : MitelmanWDFY2/S1PR5 [13q14.3/19p13.2]  
Fusion : QuiverWDFY2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDFY2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDFY2
dbVarWDFY2
ClinVarWDFY2
MonarchWDFY2
1000_GenomesWDFY2 
Exome Variant ServerWDFY2
GNOMAD BrowserENSG00000139668
Varsome BrowserWDFY2
Genomic Variants (DGV)WDFY2 [DGVbeta]
DECIPHERWDFY2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDFY2 
Mutations
ICGC Data PortalWDFY2 
TCGA Data PortalWDFY2 
Broad Tumor PortalWDFY2
OASIS PortalWDFY2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDFY2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWDFY2
Mutations and Diseases : HGMDWDFY2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch WDFY2
DgiDB (Drug Gene Interaction Database)WDFY2
DoCM (Curated mutations)WDFY2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDFY2 (select a term)
Cancer3DWDFY2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610418   
Orphanet
DisGeNETWDFY2
MedgenWDFY2
Genetic Testing Registry WDFY2
NextProtQ96P53 [Medical]
GENETestsWDFY2
Target ValidationWDFY2
Huge Navigator WDFY2 [HugePedia]
ClinGenWDFY2
Clinical trials, drugs, therapy
MyCancerGenomeWDFY2
Protein Interactions : CTDWDFY2
Pharm GKB GenePA134870231
PharosQ96P53
Clinical trialWDFY2
Miscellaneous
canSAR (ICR)WDFY2
HarmonizomeWDFY2
DataMed IndexWDFY2
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWDFY2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Wed Sep 15 22:43:53 CEST 2021

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