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WDFY3 (WD repeat and FYVE domain containing 3)

Identity

Alias_symbol (synonym)KIAA0993
ALFY
ZFYVE25
Other alias
HGNC (Hugo) WDFY3
LocusID (NCBI) 23001
Atlas_Id 75695
Location 4q21.23  [Link to chromosome band 4q21]
Location_base_pair Starts at 84669540 and ends at 84966391 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AHDC1 (1p36.11) / WDFY3 (4q21.23)ANKRD17 (4q13.3) / WDFY3 (4q21.23)WDFY3 (4q21.23) / FRAS1 (4q21.21)
WDFY3 (4q21.23) / NAV3 (12q21.2)WDFY3 (4q21.23) / WDFY3 (4q21.23)WDFY3 (4q21.23) / ZNF578 (19q13.41)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WDFY3   20751
Cards
Entrez_Gene (NCBI)WDFY3  23001  WD repeat and FYVE domain containing 3
AliasesALFY; ZFYVE25
GeneCards (Weizmann)WDFY3
Ensembl hg19 (Hinxton)ENSG00000163625 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163625 [Gene_View]  chr4:84669540-84966391 [Contig_View]  WDFY3 [Vega]
ICGC DataPortalENSG00000163625
TCGA cBioPortalWDFY3
AceView (NCBI)WDFY3
Genatlas (Paris)WDFY3
WikiGenes23001
SOURCE (Princeton)WDFY3
Genetics Home Reference (NIH)WDFY3
Genomic and cartography
GoldenPath hg38 (UCSC)WDFY3  -     chr4:84669540-84966391 -  4q21.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDFY3  -     4q21.23   [Description]    (hg19-Feb_2009)
EnsemblWDFY3 - 4q21.23 [CytoView hg19]  WDFY3 - 4q21.23 [CytoView hg38]
Mapping of homologs : NCBIWDFY3 [Mapview hg19]  WDFY3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB023210 AF131845 AF538685 AI393222 AI962188
RefSeq transcript (Entrez)NM_014991 NM_178583 NM_178585
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDFY3
Cluster EST : UnigeneHs.726339 [ NCBI ]
CGAP (NCI)Hs.726339
Alternative Splicing GalleryENSG00000163625
Gene ExpressionWDFY3 [ NCBI-GEO ]   WDFY3 [ EBI - ARRAY_EXPRESS ]   WDFY3 [ SEEK ]   WDFY3 [ MEM ]
Gene Expression Viewer (FireBrowse)WDFY3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23001
GTEX Portal (Tissue expression)WDFY3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IZQ1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IZQ1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IZQ1
Splice isoforms : SwissVarQ8IZQ1
PhosPhoSitePlusQ8IZQ1
Domaine pattern : Prosite (Expaxy)BEACH (PS50197)    PH_BEACH (PS51783)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)    ZF_FYVE (PS50178)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    BEACH_dom    ConA-like_dom    DUF4704    PH-BEACH_dom    PH_dom-like    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    Znf_FYVE    Znf_FYVE-rel    Znf_FYVE_PHD    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)Beach (PF02138)    DUF4704 (PF15787)    FYVE (PF01363)    PH_BEACH (PF14844)   
Domain families : Pfam (NCBI)pfam02138    pfam15787    pfam01363    pfam14844   
Domain families : Smart (EMBL)Beach (SM01026)  FYVE (SM00064)  WD40 (SM00320)  
Conserved Domain (NCBI)WDFY3
DMDM Disease mutations23001
Blocks (Seattle)WDFY3
PDB (SRS)3WIM   
PDB (PDBSum)3WIM   
PDB (IMB)3WIM   
PDB (RSDB)3WIM   
Structural Biology KnowledgeBase3WIM   
SCOP (Structural Classification of Proteins)3WIM   
CATH (Classification of proteins structures)3WIM   
SuperfamilyQ8IZQ1
Human Protein AtlasENSG00000163625
Peptide AtlasQ8IZQ1
HPRD10304
IPIIPI00218052   IPI00760714   IPI00382560   IPI00965066   IPI00967059   IPI00964111   
Protein Interaction databases
DIP (DOE-UCLA)Q8IZQ1
IntAct (EBI)Q8IZQ1
FunCoupENSG00000163625
BioGRIDWDFY3
STRING (EMBL)WDFY3
ZODIACWDFY3
Ontologies - Pathways
QuickGOQ8IZQ1
Ontology : AmiGObeta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity  protein binding  1-phosphatidylinositol binding  nucleus  nuclear envelope  nucleolus  cytoplasm  autophagosome  autophagosome  cytosol  plasma membrane  inclusion body  PML body  extrinsic component of membrane  nuclear membrane  Atg12-Atg5-Atg16 complex  aggrephagy  metal ion binding  extrinsic component of autophagosome membrane  
Ontology : EGO-EBIbeta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity  protein binding  1-phosphatidylinositol binding  nucleus  nuclear envelope  nucleolus  cytoplasm  autophagosome  autophagosome  cytosol  plasma membrane  inclusion body  PML body  extrinsic component of membrane  nuclear membrane  Atg12-Atg5-Atg16 complex  aggrephagy  metal ion binding  extrinsic component of autophagosome membrane  
NDEx NetworkWDFY3
Atlas of Cancer Signalling NetworkWDFY3
Wikipedia pathwaysWDFY3
Orthology - Evolution
OrthoDB23001
GeneTree (enSembl)ENSG00000163625
Phylogenetic Trees/Animal Genes : TreeFamWDFY3
HOVERGENQ8IZQ1
HOGENOMQ8IZQ1
Homologs : HomoloGeneWDFY3
Homology/Alignments : Family Browser (UCSC)WDFY3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDFY3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDFY3
dbVarWDFY3
ClinVarWDFY3
1000_GenomesWDFY3 
Exome Variant ServerWDFY3
ExAC (Exome Aggregation Consortium)WDFY3 (select the gene name)
Genetic variants : HAPMAP23001
Genomic Variants (DGV)WDFY3 [DGVbeta]
DECIPHERWDFY3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDFY3 
Mutations
ICGC Data PortalWDFY3 
TCGA Data PortalWDFY3 
Broad Tumor PortalWDFY3
OASIS PortalWDFY3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDFY3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDFY3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDFY3
DgiDB (Drug Gene Interaction Database)WDFY3
DoCM (Curated mutations)WDFY3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDFY3 (select a term)
intoGenWDFY3
Cancer3DWDFY3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenWDFY3
Genetic Testing Registry WDFY3
NextProtQ8IZQ1 [Medical]
TSGene23001
GENETestsWDFY3
Huge Navigator WDFY3 [HugePedia]
snp3D : Map Gene to Disease23001
BioCentury BCIQWDFY3
ClinGenWDFY3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23001
Chemical/Pharm GKB GenePA134903706
Clinical trialWDFY3
Miscellaneous
canSAR (ICR)WDFY3 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDFY3
EVEXWDFY3
GoPubMedWDFY3
iHOPWDFY3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:01:27 CEST 2017

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