WDHD1 (WD repeat and HMG-box DNA binding protein 1)

2017-01-01  

Identity

HGNC
WDHD1
LOCATION
14q22.2
LOCUSID
11169
ALIAS
AND-1,AND1,CHTF4,CTF4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11169
MIM: 608126
HGNC: 23170
Ensembl: ENSG00000198554

Variants:

dbSNP: 11169
ClinVar: 11169
TCGA: ENSG00000198554
COSMIC: WDHD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198554ENST00000360586O75717
ENSG00000198554ENST00000420358O75717
ENSG00000198554ENST00000455555C9JYB3
ENSG00000198554ENST00000567693H3BSQ1

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
177618132007Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.110
198052162009Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.88
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
200898642010Influence of the human cohesion establishment factor Ctf4/AND-1 on DNA replication.32
194394112009Roles of human AND-1 in chromosome transactions in S phase.23
194235402009Common variation in genes related to innate immunity and risk of adult glioma.19
217253602012And-1 is required for the stability of histone acetyltransferase Gcn5.17
242551072013Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase.17
260821892015And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.15
204069642010Risk of meningioma and common variation in genes related to innate immunity.12

Citation

Dessen P

WDHD1 (WD repeat and HMG-box DNA binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56704/wdhd1