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WDR1 (WD repeat domain 1)

Identity

Other aliasAIP1
HEL-S-52
NORI-1
HGNC (Hugo) WDR1
LocusID (NCBI) 9948
Atlas_Id 53643
Location 4p16.1  [Link to chromosome band 4p16]
Location_base_pair Starts at 10074339 and ends at 10116949 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SERPINF1 (17p13.3) / WDR1 (4p16.1)WDR1 (4p16.1) / GCDH (19p13.2)WDR1 (4p16.1) / STX4 (16p11.2)
WDR1 (4p16.1) / WDR1 (4p16.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WDR1   12754
Cards
Entrez_Gene (NCBI)WDR1  9948  WD repeat domain 1
AliasesAIP1; HEL-S-52; NORI-1
GeneCards (Weizmann)WDR1
Ensembl hg19 (Hinxton)ENSG00000071127 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071127 [Gene_View]  chr4:10074339-10116949 [Contig_View]  WDR1 [Vega]
ICGC DataPortalENSG00000071127
TCGA cBioPortalWDR1
AceView (NCBI)WDR1
Genatlas (Paris)WDR1
WikiGenes9948
SOURCE (Princeton)WDR1
Genetics Home Reference (NIH)WDR1
Genomic and cartography
GoldenPath hg38 (UCSC)WDR1  -     chr4:10074339-10116949 -  4p16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR1  -     4p16.1   [Description]    (hg19-Feb_2009)
EnsemblWDR1 - 4p16.1 [CytoView hg19]  WDR1 - 4p16.1 [CytoView hg38]
Mapping of homologs : NCBIWDR1 [Mapview hg19]  WDR1 [Mapview hg38]
OMIM604734   
Gene and transcription
Genbank (Entrez)AB010427 AB209746 AF020056 AF020260 AF274954
RefSeq transcript (Entrez)NM_005112 NM_017491
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR1
Cluster EST : UnigeneHs.713658 [ NCBI ]
CGAP (NCI)Hs.713658
Alternative Splicing GalleryENSG00000071127
Gene ExpressionWDR1 [ NCBI-GEO ]   WDR1 [ EBI - ARRAY_EXPRESS ]   WDR1 [ SEEK ]   WDR1 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9948
GTEX Portal (Tissue expression)WDR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75083   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75083  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75083
Splice isoforms : SwissVarO75083
PhosPhoSitePlusO75083
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    N2O_reductase_N    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR1
DMDM Disease mutations9948
Blocks (Seattle)WDR1
SuperfamilyO75083
Human Protein AtlasENSG00000071127
Peptide AtlasO75083
HPRD09199
IPIIPI00746165   IPI00903292   IPI00939854   IPI00556374   IPI00940664   IPI00966724   
Protein Interaction databases
DIP (DOE-UCLA)O75083
IntAct (EBI)O75083
FunCoupENSG00000071127
BioGRIDWDR1
STRING (EMBL)WDR1
ZODIACWDR1
Ontologies - Pathways
QuickGOO75083
Ontology : AmiGOpodosome  neutrophil mediated immunity  platelet degranulation  extracellular region  cytosol  cytosol  cell-cell junction  sensory perception of sound  regulation of cell shape  actin filament fragmentation  platelet formation  regulation of actin filament depolymerization  positive regulation of actin filament depolymerization  cortical actin cytoskeleton  cortical cytoskeleton organization  locomotion  establishment of planar polarity of follicular epithelium  actomyosin, actin portion  cell projection  myelin sheath  apical junction assembly  maintenance of epithelial cell apical/basal polarity  sarcomere organization  regulation of oligodendrocyte differentiation  actin filament binding  actin filament binding  regulation of ventricular cardiac muscle cell membrane repolarization  extracellular exosome  neutrophil migration  
Ontology : EGO-EBIpodosome  neutrophil mediated immunity  platelet degranulation  extracellular region  cytosol  cytosol  cell-cell junction  sensory perception of sound  regulation of cell shape  actin filament fragmentation  platelet formation  regulation of actin filament depolymerization  positive regulation of actin filament depolymerization  cortical actin cytoskeleton  cortical cytoskeleton organization  locomotion  establishment of planar polarity of follicular epithelium  actomyosin, actin portion  cell projection  myelin sheath  apical junction assembly  maintenance of epithelial cell apical/basal polarity  sarcomere organization  regulation of oligodendrocyte differentiation  actin filament binding  actin filament binding  regulation of ventricular cardiac muscle cell membrane repolarization  extracellular exosome  neutrophil migration  
NDEx NetworkWDR1
Atlas of Cancer Signalling NetworkWDR1
Wikipedia pathwaysWDR1
Orthology - Evolution
OrthoDB9948
GeneTree (enSembl)ENSG00000071127
Phylogenetic Trees/Animal Genes : TreeFamWDR1
HOVERGENO75083
HOGENOMO75083
Homologs : HomoloGeneWDR1
Homology/Alignments : Family Browser (UCSC)WDR1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR1
dbVarWDR1
ClinVarWDR1
1000_GenomesWDR1 
Exome Variant ServerWDR1
ExAC (Exome Aggregation Consortium)WDR1 (select the gene name)
Genetic variants : HAPMAP9948
Genomic Variants (DGV)WDR1 [DGVbeta]
DECIPHERWDR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR1 
Mutations
ICGC Data PortalWDR1 
TCGA Data PortalWDR1 
Broad Tumor PortalWDR1
OASIS PortalWDR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDR1
DgiDB (Drug Gene Interaction Database)WDR1
DoCM (Curated mutations)WDR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR1 (select a term)
intoGenWDR1
Cancer3DWDR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604734   
Orphanet
MedgenWDR1
Genetic Testing Registry WDR1
NextProtO75083 [Medical]
TSGene9948
GENETestsWDR1
Target ValidationWDR1
Huge Navigator WDR1 [HugePedia]
snp3D : Map Gene to Disease9948
BioCentury BCIQWDR1
ClinGenWDR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9948
Chemical/Pharm GKB GenePA37358
Clinical trialWDR1
Miscellaneous
canSAR (ICR)WDR1 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR1
EVEXWDR1
GoPubMedWDR1
iHOPWDR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:18:51 CEST 2017

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