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WDR11 (WD repeat domain 11)

Identity

Alias (NCBI)BRWD2
DR11
HH14
SRI1
WDR15
HGNC (Hugo) WDR11
HGNC Alias symbKIAA1351
FLJ10506
WDR15
HH14
DR11
SRI1
HGNC Alias namesensitization to ricin complex subunit 1
HGNC Previous nameBRWD2
HGNC Previous namebromodomain and WD repeat domain containing 2
LocusID (NCBI) 55717
Atlas_Id 51278
Location 10q26.12  [Link to chromosome band 10q26]
Location_base_pair Starts at 120851362 and ends at 120909524 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGAP1 (2q37.2) / WDR11 (10q26.12)WDR11 (10q26.12) / ZNF320 (19q13.41)ZNF320 (19q13.41) / WDR11 (10q26.12)
AGAP1 2q37.2 / WDR11 10q26.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;10)(q37;q26) AGAP1/WDR11

External links

Nomenclature
HGNC (Hugo)WDR11   13831
Cards
Entrez_Gene (NCBI)WDR11  55717  WD repeat domain 11
AliasesBRWD2; DR11; HH14; SRI1; 
WDR15
GeneCards (Weizmann)WDR11
Ensembl hg19 (Hinxton)ENSG00000120008 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120008 [Gene_View]  ENSG00000120008 [Sequence]  chr10:120851362-120909524 [Contig_View]  WDR11 [Vega]
ICGC DataPortalENSG00000120008
TCGA cBioPortalWDR11
AceView (NCBI)WDR11
Genatlas (Paris)WDR11
WikiGenes55717
SOURCE (Princeton)WDR11
Genetics Home Reference (NIH)WDR11
Genomic and cartography
GoldenPath hg38 (UCSC)WDR11  -     chr10:120851362-120909524 +  10q26.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR11  -     10q26.12   [Description]    (hg19-Feb_2009)
GoldenPathWDR11 - 10q26.12 [CytoView hg19]  WDR11 - 10q26.12 [CytoView hg38]
ImmunoBaseENSG00000120008
genome Data Viewer NCBIWDR11 [Mapview hg19]  
OMIM146110   606417   614858   
Gene and transcription
Genbank (Entrez)AB037772 AF320223 AK000579 AK001368 AK025050
RefSeq transcript (Entrez)NM_018117
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR11
Alternative Splicing GalleryENSG00000120008
Gene ExpressionWDR11 [ NCBI-GEO ]   WDR11 [ EBI - ARRAY_EXPRESS ]   WDR11 [ SEEK ]   WDR11 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR11 [ Firebrowse - Broad ]
GenevisibleExpression of WDR11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55717
GTEX Portal (Tissue expression)WDR11
Human Protein AtlasENSG00000120008-WDR11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZH6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZH6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZH6
Splice isoforms : SwissVarQ9BZH6
PhosPhoSitePlusQ9BZH6
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)   
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom_sf    WDR11   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR11
DMDM Disease mutations55717
Blocks (Seattle)WDR11
SuperfamilyQ9BZH6
Human Protein Atlas [tissue]ENSG00000120008-WDR11 [tissue]
Peptide AtlasQ9BZH6
HPRD16218
IPIIPI00412224   IPI00908722   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZH6
IntAct (EBI)Q9BZH6
FunCoupENSG00000120008
BioGRIDWDR11
STRING (EMBL)WDR11
ZODIACWDR11
Ontologies - Pathways
QuickGOQ9BZH6
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytoplasm  lysosomal membrane  trans-Golgi network  cytosol  axoneme  intracellular protein transport  heart development  regulation of smoothened signaling pathway  microtubule cytoskeleton  membrane  cytoplasmic vesicle  multicellular organism growth  ciliary basal body  cilium assembly  head development  vesicle tethering to Golgi  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytoplasm  lysosomal membrane  trans-Golgi network  cytosol  axoneme  intracellular protein transport  heart development  regulation of smoothened signaling pathway  microtubule cytoskeleton  membrane  cytoplasmic vesicle  multicellular organism growth  ciliary basal body  cilium assembly  head development  vesicle tethering to Golgi  
NDEx NetworkWDR11
Atlas of Cancer Signalling NetworkWDR11
Wikipedia pathwaysWDR11
Orthology - Evolution
OrthoDB55717
GeneTree (enSembl)ENSG00000120008
Phylogenetic Trees/Animal Genes : TreeFamWDR11
HOGENOMQ9BZH6
Homologs : HomoloGeneWDR11
Homology/Alignments : Family Browser (UCSC)WDR11
Gene fusions - Rearrangements
Fusion : MitelmanAGAP1/WDR11 [2q37.2/10q26.12]  
Fusion PortalAGAP1 2q37.2 WDR11 10q26.12 BRCA
Fusion : QuiverWDR11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR11
dbVarWDR11
ClinVarWDR11
MonarchWDR11
1000_GenomesWDR11 
Exome Variant ServerWDR11
GNOMAD BrowserENSG00000120008
Varsome BrowserWDR11
Genetic variants : HAPMAP55717
Genomic Variants (DGV)WDR11 [DGVbeta]
DECIPHERWDR11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR11 
Mutations
ICGC Data PortalWDR11 
TCGA Data PortalWDR11 
Broad Tumor PortalWDR11
OASIS PortalWDR11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWDR11
Mutations and Diseases : HGMDWDR11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDR11
DgiDB (Drug Gene Interaction Database)WDR11
DoCM (Curated mutations)WDR11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR11 (select a term)
intoGenWDR11
Cancer3DWDR11(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146110    606417    614858   
Orphanet3249    8668   
DisGeNETWDR11
MedgenWDR11
Genetic Testing Registry WDR11
NextProtQ9BZH6 [Medical]
TSGene55717
GENETestsWDR11
Target ValidationWDR11
Huge Navigator WDR11 [HugePedia]
snp3D : Map Gene to Disease55717
BioCentury BCIQWDR11
ClinGenWDR11
Clinical trials, drugs, therapy
Protein Interactions : CTD55717
Pharm GKB GenePA37818
Clinical trialWDR11
Miscellaneous
canSAR (ICR)WDR11 (select the gene name)
HarmonizomeWDR11
DataMed IndexWDR11
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR11
EVEXWDR11
GoPubMedWDR11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:38:59 CEST 2020
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