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WDR18 (WD repeat domain 18)

Identity

Alias (NCBI)Ipi3
R32184_1
HGNC (Hugo) WDR18
HGNC Alias symbIpi3
HGNC Alias nameInvolved in Processing ITS2 3 homolog (S. cerevisiae)
LocusID (NCBI) 57418
Atlas_Id 54775
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 984345 and ends at 994557 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NFIC (19p13.3)::WDR18 (19p13.3)SAE1 (19q13.32)::WDR18 (19p13.3)WDR18 (19p13.3)::H2AFX (11q23.3)
NFIC 19p13.3::WDR18 19p13.3SAE1 19q13.32::WDR18 19p13.3WDR18 19p13.3::H2AFX 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;19)(q23;p13) H2AFX::WDR18
t(11;19)(q23;p13) WDR18::H2AFX


External links

 

Nomenclature
HGNC (Hugo)WDR18   17956
Cards
Entrez_Gene (NCBI)WDR18    WD repeat domain 18
AliasesIpi3; R32184_1
GeneCards (Weizmann)WDR18
Ensembl hg19 (Hinxton)ENSG00000065268 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065268 [Gene_View]  ENSG00000065268 [Sequence]  chr19:984345-994557 [Contig_View]  WDR18 [Vega]
ICGC DataPortalENSG00000065268
TCGA cBioPortalWDR18
AceView (NCBI)WDR18
Genatlas (Paris)WDR18
SOURCE (Princeton)WDR18
Genetics Home Reference (NIH)WDR18
Genomic and cartography
GoldenPath hg38 (UCSC)WDR18  -     chr19:984345-994557 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR18  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathWDR18 - 19p13.3 [CytoView hg19]  WDR18 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000065268
Genome Data Viewer NCBIWDR18 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK131009 AL560525 BC000040 BC001648 BU154887
RefSeq transcript (Entrez)NM_001372085 NM_001372086 NM_024100
Consensus coding sequences : CCDS (NCBI)WDR18
Gene ExpressionWDR18 [ NCBI-GEO ]   WDR18 [ EBI - ARRAY_EXPRESS ]   WDR18 [ SEEK ]   WDR18 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR18 [ Firebrowse - Broad ]
GenevisibleExpression of WDR18 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57418
GTEX Portal (Tissue expression)WDR18
Human Protein AtlasENSG00000065268-WDR18 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BV38   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BV38  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BV38
PhosPhoSitePlusQ9BV38
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf    Wdr18_C_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)    WD40_alt (PF14077)   
Domain families : Pfam (NCBI)pfam00400    pfam14077   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR18
SuperfamilyQ9BV38
AlphaFold pdb e-kbQ9BV38   
Human Protein Atlas [tissue]ENSG00000065268-WDR18 [tissue]
HPRD18296
Protein Interaction databases
DIP (DOE-UCLA)Q9BV38
IntAct (EBI)Q9BV38
BioGRIDWDR18
STRING (EMBL)WDR18
ZODIACWDR18
Ontologies - Pathways
QuickGOQ9BV38
Ontology : AmiGOprotein binding  nucleoplasm  nucleoplasm  nuclear pre-replicative complex  nucleolus  rRNA processing  rRNA processing  multicellular organism development  regulation of DNA-dependent DNA replication initiation  Rix1 complex  dynein axonemal particle  
Ontology : EGO-EBIprotein binding  nucleoplasm  nucleoplasm  nuclear pre-replicative complex  nucleolus  rRNA processing  rRNA processing  multicellular organism development  regulation of DNA-dependent DNA replication initiation  Rix1 complex  dynein axonemal particle  
NDEx NetworkWDR18
Atlas of Cancer Signalling NetworkWDR18
Wikipedia pathwaysWDR18
Orthology - Evolution
OrthoDB57418
GeneTree (enSembl)ENSG00000065268
Phylogenetic Trees/Animal Genes : TreeFamWDR18
Homologs : HomoloGeneWDR18
Homology/Alignments : Family Browser (UCSC)WDR18
Gene fusions - Rearrangements
Fusion : MitelmanNFIC::WDR18 [19p13.3/19p13.3]  
Fusion : MitelmanSAE1::WDR18 [19q13.32/19p13.3]  
Fusion : MitelmanWDR18::H2AFX [19p13.3/11q23.3]  
Fusion : QuiverWDR18
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR18
dbVarWDR18
ClinVarWDR18
MonarchWDR18
1000_GenomesWDR18 
Exome Variant ServerWDR18
GNOMAD BrowserENSG00000065268
Varsome BrowserWDR18
ACMGWDR18 variants
VarityQ9BV38
Genomic Variants (DGV)WDR18 [DGVbeta]
DECIPHERWDR18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR18 
Mutations
ICGC Data PortalWDR18 
TCGA Data PortalWDR18 
Broad Tumor PortalWDR18
OASIS PortalWDR18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR18  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWDR18
Mutations and Diseases : HGMDWDR18
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaWDR18
DgiDB (Drug Gene Interaction Database)WDR18
DoCM (Curated mutations)WDR18
CIViC (Clinical Interpretations of Variants in Cancer)WDR18
Cancer3DWDR18
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETWDR18
MedgenWDR18
Genetic Testing Registry WDR18
NextProtQ9BV38 [Medical]
GENETestsWDR18
Target ValidationWDR18
Huge Navigator WDR18 [HugePedia]
ClinGenWDR18
Clinical trials, drugs, therapy
MyCancerGenomeWDR18
Protein Interactions : CTDWDR18
Pharm GKB GenePA38269
PharosQ9BV38
Clinical trialWDR18
Miscellaneous
canSAR (ICR)WDR18
HarmonizomeWDR18
ARCHS4WDR18
DataMed IndexWDR18
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWDR18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:40:42 CET 2022

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