WDR26 (WD repeat domain 26)

2013-09-01  

Identity

HGNC
WDR26
LOCATION
1q42.11
LOCUSID
80232
ALIAS
CDW2,GID7,MIP2,SKDEAS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80232
MIM: 617424
HGNC: 21208
Ensembl: ENSG00000162923

Variants:

dbSNP: 80232
ClinVar: 80232
TCGA: ENSG00000162923
COSMIC: WDR26

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162923ENST00000414423A0A499FIZ0
ENSG00000162923ENST00000445239C9JCS7
ENSG00000162923ENST00000480676H0Y9R3
ENSG00000162923ENST00000486652H0Y917
ENSG00000162923ENST00000651911Q9H7D7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
259189942015Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins.21
153786032004WDR26: a novel Gbeta-like protein, suppresses MAPK signaling pathway.14
268953802016Upregulated WDR26 serves as a scaffold to coordinate PI3K/ AKT pathway-driven breast cancer cell growth, migration, and invasion.14
220655752011The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.13
194466062009A novel WD-40 repeat protein WDR26 suppresses H2O2-induced cell death in neural cells.10
236259272013WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.8
270984532016WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway.8
286868532017WDR26 Haploinsufficiency Causes a Recognizable Syndrome of Intellectual Disability, Seizures, Abnormal Gait, and Distinctive Facial Features.8
201711912010Overexpression of MIP2, a novel WD-repeat protein, promotes proliferation of H9c2 cells.6
278356842016Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation.1

Citation

Dessen P

WDR26 (WD repeat domain 26)

Atlas Genet Cytogenet Oncol Haematol. 2013-09-01

Online version: http://atlasgeneticsoncology.org/gene/53496/wdr26