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WDR4 (WD repeat domain 4)

Identity

Alias_symbol (synonym)TRM82
TRMT82
Other alias
HGNC (Hugo) WDR4
LocusID (NCBI) 10785
Atlas_Id 75712
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 42849226 and ends at 42879583 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BRWD1 (21q22.2) / WDR4 (21q22.3)DMXL2 (15q21.2) / WDR4 (21q22.3)PIEZO1 (16q24.3) / WDR4 (21q22.3)
POFUT2 (21q22.3) / WDR4 (21q22.3)BRWD1 WDR4POFUT2 WDR4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WDR4   12756
Cards
Entrez_Gene (NCBI)WDR4  10785  WD repeat domain 4
AliasesTRM82; TRMT82
GeneCards (Weizmann)WDR4
Ensembl hg19 (Hinxton)ENSG00000160193 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160193 [Gene_View]  chr21:42849226-42879583 [Contig_View]  WDR4 [Vega]
ICGC DataPortalENSG00000160193
TCGA cBioPortalWDR4
AceView (NCBI)WDR4
Genatlas (Paris)WDR4
WikiGenes10785
SOURCE (Princeton)WDR4
Genetics Home Reference (NIH)WDR4
Genomic and cartography
GoldenPath hg38 (UCSC)WDR4  -     chr21:42849226-42879583 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR4  -     21q22.3   [Description]    (hg19-Feb_2009)
EnsemblWDR4 - 21q22.3 [CytoView hg19]  WDR4 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBIWDR4 [Mapview hg19]  WDR4 [Mapview hg38]
OMIM605924   
Gene and transcription
Genbank (Entrez)AJ243912 AJ243913 AK056343 AK292923 AK298015
RefSeq transcript (Entrez)NM_001260474 NM_001260475 NM_001260476 NM_001260477 NM_018669 NM_033661
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR4
Cluster EST : UnigeneHs.711744 [ NCBI ]
CGAP (NCI)Hs.711744
Alternative Splicing GalleryENSG00000160193
Gene ExpressionWDR4 [ NCBI-GEO ]   WDR4 [ EBI - ARRAY_EXPRESS ]   WDR4 [ SEEK ]   WDR4 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10785
GTEX Portal (Tissue expression)WDR4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57081   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57081  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57081
Splice isoforms : SwissVarP57081
PhosPhoSitePlusP57081
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Trm82    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR4
DMDM Disease mutations10785
Blocks (Seattle)WDR4
SuperfamilyP57081
Human Protein AtlasENSG00000160193
Peptide AtlasP57081
HPRD09330
IPIIPI00025718   IPI00929723   IPI00929688   
Protein Interaction databases
DIP (DOE-UCLA)P57081
IntAct (EBI)P57081
FunCoupENSG00000160193
BioGRIDWDR4
STRING (EMBL)WDR4
ZODIACWDR4
Ontologies - Pathways
QuickGOP57081
Ontology : AmiGOprotein binding  nucleus  nucleoplasm  cytosol  cytosol  tRNA modification  tRNA (guanine-N7-)-methyltransferase activity  RNA (guanine-N7)-methylation  tRNA methyltransferase complex  
Ontology : EGO-EBIprotein binding  nucleus  nucleoplasm  cytosol  cytosol  tRNA modification  tRNA (guanine-N7-)-methyltransferase activity  RNA (guanine-N7)-methylation  tRNA methyltransferase complex  
NDEx NetworkWDR4
Atlas of Cancer Signalling NetworkWDR4
Wikipedia pathwaysWDR4
Orthology - Evolution
OrthoDB10785
GeneTree (enSembl)ENSG00000160193
Phylogenetic Trees/Animal Genes : TreeFamWDR4
HOVERGENP57081
HOGENOMP57081
Homologs : HomoloGeneWDR4
Homology/Alignments : Family Browser (UCSC)WDR4
Gene fusions - Rearrangements
Fusion: TCGABRWD1 WDR4
Fusion: TCGAPOFUT2 WDR4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR4
dbVarWDR4
ClinVarWDR4
1000_GenomesWDR4 
Exome Variant ServerWDR4
ExAC (Exome Aggregation Consortium)WDR4 (select the gene name)
Genetic variants : HAPMAP10785
Genomic Variants (DGV)WDR4 [DGVbeta]
DECIPHERWDR4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR4 
Mutations
ICGC Data PortalWDR4 
TCGA Data PortalWDR4 
Broad Tumor PortalWDR4
OASIS PortalWDR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDR4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDR4
DgiDB (Drug Gene Interaction Database)WDR4
DoCM (Curated mutations)WDR4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR4 (select a term)
intoGenWDR4
Cancer3DWDR4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605924   
Orphanet
MedgenWDR4
Genetic Testing Registry WDR4
NextProtP57081 [Medical]
TSGene10785
GENETestsWDR4
Target ValidationWDR4
Huge Navigator WDR4 [HugePedia]
snp3D : Map Gene to Disease10785
BioCentury BCIQWDR4
ClinGenWDR4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10785
Chemical/Pharm GKB GenePA37360
Clinical trialWDR4
Miscellaneous
canSAR (ICR)WDR4 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR4
EVEXWDR4
GoPubMedWDR4
iHOPWDR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:48:56 CEST 2017

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