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WDR4 (WD repeat domain 4)

Identity

Alias (NCBI)GAMOS6
MIGSB
TRM82
TRMT82
Wuho
hWH
HGNC (Hugo) WDR4
HGNC Alias symbTRM82
TRMT82
Wuho
HGNC Alias nameTRM82 tRNA methyltransferase 82 homolog (S. cerevisiae)
LocusID (NCBI) 10785
Atlas_Id 57078
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 42843080 and ends at 42879583 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRWD1 (21q22.2) / WDR4 (21q22.3)DMXL2 (15q21.2) / WDR4 (21q22.3)PIEZO1 (16q24.3) / WDR4 (21q22.3)
POFUT2 (21q22.3) / WDR4 (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(21;21)(q22;q22) WDR4/PDE9A


External links

 

Nomenclature
HGNC (Hugo)WDR4   12756
Cards
Entrez_Gene (NCBI)WDR4    WD repeat domain 4
AliasesGAMOS6; MIGSB; TRM82; TRMT82; 
Wuho; hWH
GeneCards (Weizmann)WDR4
Ensembl hg19 (Hinxton)ENSG00000160193 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160193 [Gene_View]  ENSG00000160193 [Sequence]  chr21:42843080-42879583 [Contig_View]  WDR4 [Vega]
ICGC DataPortalENSG00000160193
TCGA cBioPortalWDR4
AceView (NCBI)WDR4
Genatlas (Paris)WDR4
SOURCE (Princeton)WDR4
Genetics Home Reference (NIH)WDR4
Genomic and cartography
GoldenPath hg38 (UCSC)WDR4  -     chr21:42843080-42879583 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR4  -     21q22.3   [Description]    (hg19-Feb_2009)
GoldenPathWDR4 - 21q22.3 [CytoView hg19]  WDR4 - 21q22.3 [CytoView hg38]
ImmunoBaseENSG00000160193
Genome Data Viewer NCBIWDR4 [Mapview hg19]  
OMIM605924   618346   618347   
Gene and transcription
Genbank (Entrez)AJ243912 AJ243913 AK056343 AK292923 AK298015
RefSeq transcript (Entrez)NM_001260474 NM_001260475 NM_001260476 NM_001260477 NM_018669 NM_033661
Consensus coding sequences : CCDS (NCBI)WDR4
Gene ExpressionWDR4 [ NCBI-GEO ]   WDR4 [ EBI - ARRAY_EXPRESS ]   WDR4 [ SEEK ]   WDR4 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR4 [ Firebrowse - Broad ]
GenevisibleExpression of WDR4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10785
GTEX Portal (Tissue expression)WDR4
Human Protein AtlasENSG00000160193-WDR4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57081   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57081  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57081
PhosPhoSitePlusP57081
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Trm82    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR4
SuperfamilyP57081
AlphaFold pdb e-kbP57081   
Human Protein Atlas [tissue]ENSG00000160193-WDR4 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P57081
IntAct (EBI)P57081
BioGRIDWDR4
STRING (EMBL)WDR4
ZODIACWDR4
Ontologies - Pathways
QuickGOP57081
Ontology : AmiGOprotein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  chromosome  cytosol  cytosol  tRNA modification  cellular response to DNA damage stimulus  tRNA (guanine-N7-)-methyltransferase activity  tRNA (guanine-N7-)-methyltransferase activity  tRNA methyltransferase complex  tRNA methyltransferase complex  tRNA (guanine-N7)-methylation  
Ontology : EGO-EBIprotein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  chromosome  cytosol  cytosol  tRNA modification  cellular response to DNA damage stimulus  tRNA (guanine-N7-)-methyltransferase activity  tRNA (guanine-N7-)-methyltransferase activity  tRNA methyltransferase complex  tRNA methyltransferase complex  tRNA (guanine-N7)-methylation  
NDEx NetworkWDR4
Atlas of Cancer Signalling NetworkWDR4
Wikipedia pathwaysWDR4
Orthology - Evolution
OrthoDB10785
GeneTree (enSembl)ENSG00000160193
Phylogenetic Trees/Animal Genes : TreeFamWDR4
Homologs : HomoloGeneWDR4
Homology/Alignments : Family Browser (UCSC)WDR4
Gene fusions - Rearrangements
Fusion : QuiverWDR4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR4
dbVarWDR4
ClinVarWDR4
MonarchWDR4
1000_GenomesWDR4 
Exome Variant ServerWDR4
GNOMAD BrowserENSG00000160193
Varsome BrowserWDR4
ACMGWDR4 variants
VarityP57081
Genomic Variants (DGV)WDR4 [DGVbeta]
DECIPHERWDR4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR4 
Mutations
ICGC Data PortalWDR4 
TCGA Data PortalWDR4 
Broad Tumor PortalWDR4
OASIS PortalWDR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWDR4
Mutations and Diseases : HGMDWDR4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaWDR4
DgiDB (Drug Gene Interaction Database)WDR4
DoCM (Curated mutations)WDR4
CIViC (Clinical Interpretations of Variants in Cancer)WDR4
Cancer3DWDR4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605924    618346    618347   
Orphanet
DisGeNETWDR4
MedgenWDR4
Genetic Testing Registry WDR4
NextProtP57081 [Medical]
GENETestsWDR4
Target ValidationWDR4
Huge Navigator WDR4 [HugePedia]
ClinGenWDR4
Clinical trials, drugs, therapy
MyCancerGenomeWDR4
Protein Interactions : CTDWDR4
Pharm GKB GenePA37360
PharosP57081
Clinical trialWDR4
Miscellaneous
canSAR (ICR)WDR4
HarmonizomeWDR4
DataMed IndexWDR4
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWDR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:38:18 CEST 2021

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