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WDR4 (WD repeat domain 4)

Identity

Other aliasTRM82
TRMT82
HGNC (Hugo) WDR4
LocusID (NCBI) 10785
Atlas_Id 57078
Location 2p24.1  [Link to chromosome band 2p24]
Location_base_pair Starts at 42843080 and ends at 42879583 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BRWD1 (21q22.2) / WDR4 (21q22.3)DMXL2 (15q21.2) / WDR4 (21q22.3)PIEZO1 (16q24.3) / WDR4 (21q22.3)
POFUT2 (21q22.3) / WDR4 (21q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(21;21)(q22;q22) WDR4/PDE9A


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  BRWD1/WDR4 (21q22)
POFUT2/WDR4 (21q22)


External links

Nomenclature
HGNC (Hugo)WDR4   12756
Cards
Entrez_Gene (NCBI)WDR4  10785  WD repeat domain 4
AliasesTRM82; TRMT82
GeneCards (Weizmann)WDR4
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  chr21:42843080-42879583 [Contig_View]  WDR4 [Vega]
TCGA cBioPortalWDR4
AceView (NCBI)WDR4
Genatlas (Paris)WDR4
WikiGenes10785
SOURCE (Princeton)WDR4
Genetics Home Reference (NIH)WDR4
Genomic and cartography
GoldenPath hg38 (UCSC)WDR4  -     chr21:42843080-42879583 -  2p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR4  -     2p24.1   [Description]    (hg19-Feb_2009)
EnsemblWDR4 - 2p24.1 [CytoView hg19]  WDR4 - 2p24.1 [CytoView hg38]
Mapping of homologs : NCBIWDR4 [Mapview hg19]  WDR4 [Mapview hg38]
OMIM605924   
Gene and transcription
Genbank (Entrez)AJ243912 AJ243913 AK056343 AK292923 AK298015
RefSeq transcript (Entrez)NM_001260474 NM_001260475 NM_001260476 NM_001260477 NM_018669 NM_033661
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR4
Cluster EST : UnigeneHs.711744 [ NCBI ]
CGAP (NCI)Hs.711744
Gene ExpressionWDR4 [ NCBI-GEO ]   WDR4 [ EBI - ARRAY_EXPRESS ]   WDR4 [ SEEK ]   WDR4 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10785
GTEX Portal (Tissue expression)WDR4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57081   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57081  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57081
Splice isoforms : SwissVarP57081
PhosPhoSitePlusP57081
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Trm82    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR4
DMDM Disease mutations10785
Blocks (Seattle)WDR4
SuperfamilyP57081
Peptide AtlasP57081
IPIIPI00025718   IPI00929723   IPI00929688   
Protein Interaction databases
DIP (DOE-UCLA)P57081
IntAct (EBI)P57081
BioGRIDWDR4
STRING (EMBL)WDR4
ZODIACWDR4
Ontologies - Pathways
QuickGOP57081
Ontology : AmiGOprotein binding  nucleus  nucleus  nucleoplasm  cytosol  cytosol  tRNA modification  tRNA (guanine-N7-)-methyltransferase activity  tRNA (guanine-N7-)-methyltransferase activity  tRNA methyltransferase complex  tRNA methyltransferase complex  tRNA (guanine-N7)-methylation  
Ontology : EGO-EBIprotein binding  nucleus  nucleus  nucleoplasm  cytosol  cytosol  tRNA modification  tRNA (guanine-N7-)-methyltransferase activity  tRNA (guanine-N7-)-methyltransferase activity  tRNA methyltransferase complex  tRNA methyltransferase complex  tRNA (guanine-N7)-methylation  
NDEx NetworkWDR4
Atlas of Cancer Signalling NetworkWDR4
Wikipedia pathwaysWDR4
Orthology - Evolution
OrthoDB10785
Phylogenetic Trees/Animal Genes : TreeFamWDR4
HOVERGENP57081
HOGENOMP57081
Homologs : HomoloGeneWDR4
Homology/Alignments : Family Browser (UCSC)WDR4
Gene fusions - Rearrangements
Fusion : QuiverWDR4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR4
dbVarWDR4
ClinVarWDR4
1000_GenomesWDR4 
Exome Variant ServerWDR4
Varsome BrowserWDR4
Genetic variants : HAPMAP10785
Genomic Variants (DGV)WDR4 [DGVbeta]
DECIPHERWDR4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR4 
Mutations
ICGC Data PortalWDR4 
TCGA Data PortalWDR4 
Broad Tumor PortalWDR4
OASIS PortalWDR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDR4
BioMutasearch WDR4
DgiDB (Drug Gene Interaction Database)WDR4
DoCM (Curated mutations)WDR4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR4 (select a term)
intoGenWDR4
Cancer3DWDR4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605924   
Orphanet
DisGeNETWDR4
MedgenWDR4
Genetic Testing Registry WDR4
NextProtP57081 [Medical]
TSGene10785
GENETestsWDR4
Target ValidationWDR4
Huge Navigator WDR4 [HugePedia]
snp3D : Map Gene to Disease10785
BioCentury BCIQWDR4
ClinGenWDR4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10785
Chemical/Pharm GKB GenePA37360
Clinical trialWDR4
Miscellaneous
canSAR (ICR)WDR4 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR4
EVEXWDR4
GoPubMedWDR4
iHOPWDR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 11:41:37 CEST 2018

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