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WDR5 (WD repeat domain 5)

Identity

Alias_symbol (synonym)SWD3
CFAP89
Other aliasBIG-3
HGNC (Hugo) WDR5
LocusID (NCBI) 11091
Atlas_Id 51091
Location 9q34.2  [Link to chromosome band 9q34]
Location_base_pair Starts at 134136088 and ends at 134159972 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WDR5   12757
Cards
Entrez_Gene (NCBI)WDR5  11091  WD repeat domain 5
AliasesBIG-3; CFAP89; SWD3
GeneCards (Weizmann)WDR5
Ensembl hg19 (Hinxton)ENSG00000196363 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196363 [Gene_View]  chr9:134136088-134159972 [Contig_View]  WDR5 [Vega]
ICGC DataPortalENSG00000196363
TCGA cBioPortalWDR5
AceView (NCBI)WDR5
Genatlas (Paris)WDR5
WikiGenes11091
SOURCE (Princeton)WDR5
Genetics Home Reference (NIH)WDR5
Genomic and cartography
GoldenPath hg38 (UCSC)WDR5  -     chr9:134136088-134159972 +  9q34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR5  -     9q34.2   [Description]    (hg19-Feb_2009)
EnsemblWDR5 - 9q34.2 [CytoView hg19]  WDR5 - 9q34.2 [CytoView hg38]
Mapping of homologs : NCBIWDR5 [Mapview hg19]  WDR5 [Mapview hg38]
OMIM609012   
Gene and transcription
Genbank (Entrez)AA490313 AJ011376 AK000552 AK024484 AK025810
RefSeq transcript (Entrez)NM_017588 NM_052821
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR5
Cluster EST : UnigeneHs.397638 [ NCBI ]
CGAP (NCI)Hs.397638
Alternative Splicing GalleryENSG00000196363
Gene ExpressionWDR5 [ NCBI-GEO ]   WDR5 [ EBI - ARRAY_EXPRESS ]   WDR5 [ SEEK ]   WDR5 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11091
GTEX Portal (Tissue expression)WDR5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61964   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61964  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61964
Splice isoforms : SwissVarP61964
PhosPhoSitePlusP61964
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR5
DMDM Disease mutations11091
Blocks (Seattle)WDR5
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP61964
Human Protein AtlasENSG00000196363
Peptide AtlasP61964
HPRD10614
IPIIPI00005492   IPI00386309   
Protein Interaction databases
DIP (DOE-UCLA)P61964
IntAct (EBI)P61964
FunCoupENSG00000196363
BioGRIDWDR5
STRING (EMBL)WDR5
ZODIACWDR5
Ontologies - Pathways
QuickGOP61964
Ontology : AmiGOhistone acetyltransferase complex  skeletal system development  protein binding  nucleus  nucleoplasm  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  transcription, DNA-templated  histone-lysine N-methyltransferase activity  neuron projection development  methylated histone binding  histone methyltransferase complex  positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter  ciliary basal body  histone methyltransferase activity (H3-K4 specific)  histone H3 acetylation  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  MLL3/4 complex  histone acetyltransferase activity (H4-K16 specific)  Set1C/COMPASS complex  histone H3-K4 methylation  cilium assembly  MLL1 complex  
Ontology : EGO-EBIhistone acetyltransferase complex  skeletal system development  protein binding  nucleus  nucleoplasm  nucleoplasm  Ada2/Gcn5/Ada3 transcription activator complex  transcription, DNA-templated  histone-lysine N-methyltransferase activity  neuron projection development  methylated histone binding  histone methyltransferase complex  positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter  ciliary basal body  histone methyltransferase activity (H3-K4 specific)  histone H3 acetylation  histone H4-K5 acetylation  histone H4-K8 acetylation  histone H4-K16 acetylation  histone acetyltransferase activity (H4-K5 specific)  histone acetyltransferase activity (H4-K8 specific)  MLL3/4 complex  histone acetyltransferase activity (H4-K16 specific)  Set1C/COMPASS complex  histone H3-K4 methylation  cilium assembly  MLL1 complex  
NDEx NetworkWDR5
Atlas of Cancer Signalling NetworkWDR5
Wikipedia pathwaysWDR5
Orthology - Evolution
OrthoDB11091
GeneTree (enSembl)ENSG00000196363
Phylogenetic Trees/Animal Genes : TreeFamWDR5
HOVERGENP61964
HOGENOMP61964
Homologs : HomoloGeneWDR5
Homology/Alignments : Family Browser (UCSC)WDR5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR5
dbVarWDR5
ClinVarWDR5
1000_GenomesWDR5 
Exome Variant ServerWDR5
ExAC (Exome Aggregation Consortium)WDR5 (select the gene name)
Genetic variants : HAPMAP11091
Genomic Variants (DGV)WDR5 [DGVbeta]
DECIPHERWDR5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR5 
Mutations
ICGC Data PortalWDR5 
TCGA Data PortalWDR5 
Broad Tumor PortalWDR5
OASIS PortalWDR5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDR5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDR5
DgiDB (Drug Gene Interaction Database)WDR5
DoCM (Curated mutations)WDR5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR5 (select a term)
intoGenWDR5
Cancer3DWDR5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609012   
Orphanet
MedgenWDR5
Genetic Testing Registry WDR5
NextProtP61964 [Medical]
TSGene11091
GENETestsWDR5
Huge Navigator WDR5 [HugePedia]
snp3D : Map Gene to Disease11091
BioCentury BCIQWDR5
ClinGenWDR5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11091
Chemical/Pharm GKB GenePA37361
Clinical trialWDR5
Miscellaneous
canSAR (ICR)WDR5 (select the gene name)
Probes
Litterature
PubMed138 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR5
EVEXWDR5
GoPubMedWDR5
iHOPWDR5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:44:05 CEST 2017

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