WDR5 (WD repeat domain 5)

2009-09-01  

Identity

HGNC
WDR5
LOCATION
9q34.2
LOCUSID
11091
ALIAS
BIG-3,CFAP89,SWD3

Other Information

Locus ID:

NCBI: 11091
MIM: 609012
HGNC: 12757
Ensembl: ENSG00000196363

Variants:

dbSNP: 11091
ClinVar: 11091
TCGA: ENSG00000196363
COSMIC: WDR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196363ENST00000358625P61964
ENSG00000196363ENST00000608739V9GZ59
ENSG00000196363ENST00000608937V9GYQ5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
PKMTs methylate histone lysinesREACTOMER-HSA-3214841
RMTs methylate histone argininesREACTOMER-HSA-3214858
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

References

Pubmed IDYearTitleCitations
168781302006Regulation of MLL1 H3K4 methyltransferase activity by its core components.340
159609742005WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.330
168299592006Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.98
168299602006Molecular recognition of histone H3 by the WD40 protein WDR5.97
200188522010Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.97
271475982016LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern.93
169466992006Structural basis for molecular recognition and presentation of histone H3 by WDR5.73
188294572008A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex.70
188294592008Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.70
188406062008WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket.67

Citation

Dessen P

WDR5 (WD repeat domain 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51091/wdr5