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WDR53 (WD repeat domain 53)

Identity

Alias_symbol (synonym)MGC64882
MGC12928
Other alias-
HGNC (Hugo) WDR53
LocusID (NCBI) 348793
Atlas_Id 54777
Location 3q29  [Link to chromosome band 3q29]
Location_base_pair Starts at 196554179 and ends at 196568674 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MIR21 (17q23.1) / WDR53 (3q29)SCRN1 (7p14.3) / WDR53 (3q29)WDR53 (3q29) / RNU5E-1 (5q14.1)
SCRN1 7p14.3 / WDR53 3q29

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)WDR53   28786
Cards
Entrez_Gene (NCBI)WDR53  348793  WD repeat domain 53
Aliases
GeneCards (Weizmann)WDR53
Ensembl hg19 (Hinxton)ENSG00000185798 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185798 [Gene_View]  chr3:196554179-196568674 [Contig_View]  WDR53 [Vega]
ICGC DataPortalENSG00000185798
TCGA cBioPortalWDR53
AceView (NCBI)WDR53
Genatlas (Paris)WDR53
WikiGenes348793
SOURCE (Princeton)WDR53
Genetics Home Reference (NIH)WDR53
Genomic and cartography
GoldenPath hg38 (UCSC)WDR53  -     chr3:196554179-196568674 -  3q29   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR53  -     3q29   [Description]    (hg19-Feb_2009)
EnsemblWDR53 - 3q29 [CytoView hg19]  WDR53 - 3q29 [CytoView hg38]
Mapping of homologs : NCBIWDR53 [Mapview hg19]  WDR53 [Mapview hg38]
OMIM615110   
Gene and transcription
Genbank (Entrez)AI803796 AK314105 BC054030 BU186444 EF011620
RefSeq transcript (Entrez)NM_001345906 NM_001345907 NM_001345908 NM_001345909 NM_001345910 NM_001345911 NM_001345912 NM_001345913 NM_001345914 NM_001345915 NM_001345917 NM_001345918 NM_182627
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR53
Cluster EST : UnigeneHs.385865 [ NCBI ]
CGAP (NCI)Hs.385865
Alternative Splicing GalleryENSG00000185798
Gene ExpressionWDR53 [ NCBI-GEO ]   WDR53 [ EBI - ARRAY_EXPRESS ]   WDR53 [ SEEK ]   WDR53 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR53 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)348793
GTEX Portal (Tissue expression)WDR53
Human Protein AtlasENSG00000185798-WDR53 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z5U6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z5U6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z5U6
Splice isoforms : SwissVarQ7Z5U6
PhosPhoSitePlusQ7Z5U6
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Apc4_WD40_dom    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)ANAPC4_WD40 (PF12894)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12894    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR53
DMDM Disease mutations348793
Blocks (Seattle)WDR53
SuperfamilyQ7Z5U6
Human Protein Atlas [tissue]ENSG00000185798-WDR53 [tissue]
Peptide AtlasQ7Z5U6
HPRD14700
IPIIPI00063389   IPI00926260   IPI00926481   IPI00926664   IPI00926902   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z5U6
IntAct (EBI)Q7Z5U6
FunCoupENSG00000185798
BioGRIDWDR53
STRING (EMBL)WDR53
ZODIACWDR53
Ontologies - Pathways
QuickGOQ7Z5U6
Ontology : AmiGOcytoplasm  
Ontology : EGO-EBIcytoplasm  
NDEx NetworkWDR53
Atlas of Cancer Signalling NetworkWDR53
Wikipedia pathwaysWDR53
Orthology - Evolution
OrthoDB348793
GeneTree (enSembl)ENSG00000185798
Phylogenetic Trees/Animal Genes : TreeFamWDR53
HOVERGENQ7Z5U6
HOGENOMQ7Z5U6
Homologs : HomoloGeneWDR53
Homology/Alignments : Family Browser (UCSC)WDR53
Gene fusions - Rearrangements
Fusion : MitelmanMIR21/WDR53 [17q23.1/3q29]  [t(3;17)(q29;q23)]  
Fusion : MitelmanSCRN1/WDR53 [7p14.3/3q29]  [t(3;7)(q29;p14)]  
Fusion: TCGA_MDACCSCRN1 7p14.3 WDR53 3q29 LUSC
Tumor Fusion PortalWDR53
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR53 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR53
dbVarWDR53
ClinVarWDR53
1000_GenomesWDR53 
Exome Variant ServerWDR53
ExAC (Exome Aggregation Consortium)ENSG00000185798
GNOMAD BrowserENSG00000185798
Genetic variants : HAPMAP348793
Genomic Variants (DGV)WDR53 [DGVbeta]
DECIPHERWDR53 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR53 
Mutations
ICGC Data PortalWDR53 
TCGA Data PortalWDR53 
Broad Tumor PortalWDR53
OASIS PortalWDR53 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR53  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDR53
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDR53
DgiDB (Drug Gene Interaction Database)WDR53
DoCM (Curated mutations)WDR53 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR53 (select a term)
intoGenWDR53
Cancer3DWDR53(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615110   
Orphanet
DisGeNETWDR53
MedgenWDR53
Genetic Testing Registry WDR53
NextProtQ7Z5U6 [Medical]
TSGene348793
GENETestsWDR53
Target ValidationWDR53
Huge Navigator WDR53 [HugePedia]
snp3D : Map Gene to Disease348793
BioCentury BCIQWDR53
ClinGenWDR53
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD348793
Chemical/Pharm GKB GenePA134948456
Clinical trialWDR53
Miscellaneous
canSAR (ICR)WDR53 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR53
EVEXWDR53
GoPubMedWDR53
iHOPWDR53
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:41:37 CET 2017

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