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WDR6 (WD repeat domain 6)

Identity

Other alias-
HGNC (Hugo) WDR6
LocusID (NCBI) 11180
Atlas_Id 56110
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49007062 and ends at 49015953 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AD_1 () / WDR6 (3p21.31)RPS14 (5q33.1) / WDR6 (3p21.31)WDR6 (3p21.31) / CRK (17p13.3)
WDR6 (3p21.31) / DEFA1 (8p23.1)WDR6 (3p21.31) / MXI1 (10q25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WDR6   12758
Cards
Entrez_Gene (NCBI)WDR6  11180  WD repeat domain 6
Aliases
GeneCards (Weizmann)WDR6
Ensembl hg19 (Hinxton)ENSG00000178252 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178252 [Gene_View]  chr3:49007062-49015953 [Contig_View]  WDR6 [Vega]
ICGC DataPortalENSG00000178252
TCGA cBioPortalWDR6
AceView (NCBI)WDR6
Genatlas (Paris)WDR6
WikiGenes11180
SOURCE (Princeton)WDR6
Genetics Home Reference (NIH)WDR6
Genomic and cartography
GoldenPath hg38 (UCSC)WDR6  -     chr3:49007062-49015953 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR6  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblWDR6 - 3p21.31 [CytoView hg19]  WDR6 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIWDR6 [Mapview hg19]  WDR6 [Mapview hg38]
OMIM606031   
Gene and transcription
Genbank (Entrez)AF099100 AI357001 AI636120 AK001080 AK022719
RefSeq transcript (Entrez)NM_001320546 NM_001320547 NM_018031
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR6
Cluster EST : UnigeneHs.654815 [ NCBI ]
CGAP (NCI)Hs.654815
Alternative Splicing GalleryENSG00000178252
Gene ExpressionWDR6 [ NCBI-GEO ]   WDR6 [ EBI - ARRAY_EXPRESS ]   WDR6 [ SEEK ]   WDR6 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11180
GTEX Portal (Tissue expression)WDR6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NNW5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NNW5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NNW5
Splice isoforms : SwissVarQ9NNW5
PhosPhoSitePlusQ9NNW5
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Gal_Oxase/kelch_b-propeller    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR6
DMDM Disease mutations11180
Blocks (Seattle)WDR6
SuperfamilyQ9NNW5
Human Protein AtlasENSG00000178252
Peptide AtlasQ9NNW5
HPRD06912
IPIIPI00019714   IPI00797612   IPI00927196   IPI00927338   IPI00013953   IPI00926928   IPI00924672   IPI00927558   IPI01012533   
Protein Interaction databases
DIP (DOE-UCLA)Q9NNW5
IntAct (EBI)Q9NNW5
FunCoupENSG00000178252
BioGRIDWDR6
STRING (EMBL)WDR6
ZODIACWDR6
Ontologies - Pathways
QuickGOQ9NNW5
Ontology : AmiGORNA binding  protein binding  cytoplasm  cytosol  plasma membrane  cell cycle arrest  COP9 signalosome  negative regulation of cell proliferation  negative regulation of autophagy  
Ontology : EGO-EBIRNA binding  protein binding  cytoplasm  cytosol  plasma membrane  cell cycle arrest  COP9 signalosome  negative regulation of cell proliferation  negative regulation of autophagy  
NDEx NetworkWDR6
Atlas of Cancer Signalling NetworkWDR6
Wikipedia pathwaysWDR6
Orthology - Evolution
OrthoDB11180
GeneTree (enSembl)ENSG00000178252
Phylogenetic Trees/Animal Genes : TreeFamWDR6
HOVERGENQ9NNW5
HOGENOMQ9NNW5
Homologs : HomoloGeneWDR6
Homology/Alignments : Family Browser (UCSC)WDR6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR6
dbVarWDR6
ClinVarWDR6
1000_GenomesWDR6 
Exome Variant ServerWDR6
ExAC (Exome Aggregation Consortium)WDR6 (select the gene name)
Genetic variants : HAPMAP11180
Genomic Variants (DGV)WDR6 [DGVbeta]
DECIPHERWDR6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR6 
Mutations
ICGC Data PortalWDR6 
TCGA Data PortalWDR6 
Broad Tumor PortalWDR6
OASIS PortalWDR6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDR6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDR6
DgiDB (Drug Gene Interaction Database)WDR6
DoCM (Curated mutations)WDR6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR6 (select a term)
intoGenWDR6
Cancer3DWDR6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606031   
Orphanet
MedgenWDR6
Genetic Testing Registry WDR6
NextProtQ9NNW5 [Medical]
TSGene11180
GENETestsWDR6
Huge Navigator WDR6 [HugePedia]
snp3D : Map Gene to Disease11180
BioCentury BCIQWDR6
ClinGenWDR6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11180
Chemical/Pharm GKB GenePA37362
Clinical trialWDR6
Miscellaneous
canSAR (ICR)WDR6 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR6
EVEXWDR6
GoPubMedWDR6
iHOPWDR6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:44:06 CEST 2017

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