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WDR6 (WD repeat domain 6)

Identity

Alias (NCBI)-
HGNC (Hugo) WDR6
LocusID (NCBI) 11180
Atlas_Id 56110
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49007391 and ends at 49015951 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AD_1 () / WDR6 (3p21.31)RPS14 (5q33.1) / WDR6 (3p21.31)WDR6 (3p21.31) / CRK (17p13.3)
WDR6 (3p21.31) / DEFA1 (8p23.1)WDR6 (3p21.31) / MXI1 (10q25.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)WDR6   12758
Cards
Entrez_Gene (NCBI)WDR6    WD repeat domain 6
Aliases
GeneCards (Weizmann)WDR6
Ensembl hg19 (Hinxton)ENSG00000178252 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178252 [Gene_View]  ENSG00000178252 [Sequence]  chr3:49007391-49015951 [Contig_View]  WDR6 [Vega]
ICGC DataPortalENSG00000178252
TCGA cBioPortalWDR6
AceView (NCBI)WDR6
Genatlas (Paris)WDR6
SOURCE (Princeton)WDR6
Genetics Home Reference (NIH)WDR6
Genomic and cartography
GoldenPath hg38 (UCSC)WDR6  -     chr3:49007391-49015951 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR6  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathWDR6 - 3p21.31 [CytoView hg19]  WDR6 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000178252
Genome Data Viewer NCBIWDR6 [Mapview hg19]  
OMIM606031   
Gene and transcription
Genbank (Entrez)AF099100 AI357001 AI636120 AK001080 AK022719
RefSeq transcript (Entrez)NM_001320546 NM_001320547 NM_018031
Consensus coding sequences : CCDS (NCBI)WDR6
Gene ExpressionWDR6 [ NCBI-GEO ]   WDR6 [ EBI - ARRAY_EXPRESS ]   WDR6 [ SEEK ]   WDR6 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR6 [ Firebrowse - Broad ]
GenevisibleExpression of WDR6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11180
GTEX Portal (Tissue expression)WDR6
Human Protein AtlasENSG00000178252-WDR6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NNW5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NNW5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NNW5
PhosPhoSitePlusQ9NNW5
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Gal_Oxase/kelch_b-propeller    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR6
SuperfamilyQ9NNW5
AlphaFold pdb e-kbQ9NNW5   
Human Protein Atlas [tissue]ENSG00000178252-WDR6 [tissue]
HPRD06912
Protein Interaction databases
DIP (DOE-UCLA)Q9NNW5
IntAct (EBI)Q9NNW5
BioGRIDWDR6
STRING (EMBL)WDR6
ZODIACWDR6
Ontologies - Pathways
QuickGOQ9NNW5
Ontology : AmiGORNA binding  protein binding  cytoplasm  cytoplasm  cytosol  plasma membrane  cell cycle  negative regulation of cell population proliferation  negative regulation of autophagy  tRNA methylation  insulin receptor substrate binding  regulation of cell cycle  tRNA (guanosine 32-2'-O)-methyltransferase activity  
Ontology : EGO-EBIRNA binding  protein binding  cytoplasm  cytoplasm  cytosol  plasma membrane  cell cycle  negative regulation of cell population proliferation  negative regulation of autophagy  tRNA methylation  insulin receptor substrate binding  regulation of cell cycle  tRNA (guanosine 32-2'-O)-methyltransferase activity  
NDEx NetworkWDR6
Atlas of Cancer Signalling NetworkWDR6
Wikipedia pathwaysWDR6
Orthology - Evolution
OrthoDB11180
GeneTree (enSembl)ENSG00000178252
Phylogenetic Trees/Animal Genes : TreeFamWDR6
Homologs : HomoloGeneWDR6
Homology/Alignments : Family Browser (UCSC)WDR6
Gene fusions - Rearrangements
Fusion : QuiverWDR6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR6
dbVarWDR6
ClinVarWDR6
MonarchWDR6
1000_GenomesWDR6 
Exome Variant ServerWDR6
GNOMAD BrowserENSG00000178252
Varsome BrowserWDR6
ACMGWDR6 variants
VarityQ9NNW5
Genomic Variants (DGV)WDR6 [DGVbeta]
DECIPHERWDR6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR6 
Mutations
ICGC Data PortalWDR6 
TCGA Data PortalWDR6 
Broad Tumor PortalWDR6
OASIS PortalWDR6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWDR6
Mutations and Diseases : HGMDWDR6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaWDR6
DgiDB (Drug Gene Interaction Database)WDR6
DoCM (Curated mutations)WDR6
CIViC (Clinical Interpretations of Variants in Cancer)WDR6
Cancer3DWDR6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606031   
Orphanet
DisGeNETWDR6
MedgenWDR6
Genetic Testing Registry WDR6
NextProtQ9NNW5 [Medical]
GENETestsWDR6
Target ValidationWDR6
Huge Navigator WDR6 [HugePedia]
ClinGenWDR6
Clinical trials, drugs, therapy
MyCancerGenomeWDR6
Protein Interactions : CTDWDR6
Pharm GKB GenePA37362
PharosQ9NNW5
Clinical trialWDR6
Miscellaneous
canSAR (ICR)WDR6
HarmonizomeWDR6
DataMed IndexWDR6
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWDR6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:38:19 CEST 2021

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