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WDR74 (WD repeat domain 74)

Identity

Alias (NCBI)Nsa1
HGNC (Hugo) WDR74
HGNC Alias symbFLJ10439
LocusID (NCBI) 54663
Atlas_Id 75729
Location 11q12.3  [Link to chromosome band 11q12]
Location_base_pair Starts at 62832905 and ends at 62840156 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF17 (11q13.4) / WDR74 (11q12.3)NXF1 (11q12.3) / WDR74 (11q12.3)STIP1 (11q13.1) / WDR74 (11q12.3)
STX5 (11q12.3) / WDR74 (11q12.3)WDR74 (11q12.3) / ANKS1B (12q23.1)WDR74 (11q12.3) / DHTKD1 (10p14)
WDR74 (11q12.3) / DOT1L (19p13.3)WDR74 (11q12.3) / GALC (14q31.3)WDR74 (11q12.3) / GLUL (1q25.3)
WDR74 (11q12.3) / GNAI3 (1p13.3)WDR74 (11q12.3) / GTF3C5 (9q34.2)WDR74 (11q12.3) / IMMP2L (7q31.1)
WDR74 (11q12.3) / INTS7 (1q32.3)WDR74 (11q12.3) / KNG1 (3q27.3)WDR74 (11q12.3) / LAMP2 (Xq24)
WDR74 (11q12.3) / LILRB3 (19q13.42)WDR74 (11q12.3) / PAQR6 (1q22)WDR74 (11q12.3) / PITRM1 (10p15.2)
WDR74 (11q12.3) / RALGDS (9q34.2)WDR74 (11q12.3) / RMND5A (2p11.2)WDR74 (11q12.3) / SART3 (12q23.3)
WDR74 (11q12.3) / SEPT8 (5q31.1)WDR74 (11q12.3) / SRGAP2 (1q32.1)WDR74 (11q12.3) / SUGP2 (19p13.11)
WDR74 (11q12.3) / TAPBPL (12p13.31)WDR74 (11q12.3) / TMCC2 (1q32.1)WDR74 (11q12.3) / TMEM25 (11q23.3)
WDR74 (11q12.3) / TRMT12 (8q24.13)WDR74 (11q12.3) / ZNF143 (11p15.4)ARHGEF17 WDR74
STX5 WDR74NXF1 WDR74

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)WDR74   25529
Cards
Entrez_Gene (NCBI)WDR74    WD repeat domain 74
AliasesNsa1
GeneCards (Weizmann)WDR74
Ensembl hg19 (Hinxton)ENSG00000133316 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133316 [Gene_View]  ENSG00000133316 [Sequence]  chr11:62832905-62840156 [Contig_View]  WDR74 [Vega]
ICGC DataPortalENSG00000133316
TCGA cBioPortalWDR74
AceView (NCBI)WDR74
Genatlas (Paris)WDR74
SOURCE (Princeton)WDR74
Genetics Home Reference (NIH)WDR74
Genomic and cartography
GoldenPath hg38 (UCSC)WDR74  -     chr11:62832905-62840156 -  11q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR74  -     11q12.3   [Description]    (hg19-Feb_2009)
GoldenPathWDR74 - 11q12.3 [CytoView hg19]  WDR74 - 11q12.3 [CytoView hg38]
ImmunoBaseENSG00000133316
Genome Data Viewer NCBIWDR74 [Mapview hg19]  
OMIM617947   
Gene and transcription
Genbank (Entrez)AK001301 AK025383 AK292330 AK303186 AY500828
RefSeq transcript (Entrez)NM_001307977 NM_001369447 NM_001369448 NM_001369449 NM_001369450 NM_001369451 NM_001369453 NM_018093
Consensus coding sequences : CCDS (NCBI)WDR74
Gene ExpressionWDR74 [ NCBI-GEO ]   WDR74 [ EBI - ARRAY_EXPRESS ]   WDR74 [ SEEK ]   WDR74 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR74 [ Firebrowse - Broad ]
GenevisibleExpression of WDR74 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54663
GTEX Portal (Tissue expression)WDR74
Human Protein AtlasENSG00000133316-WDR74 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6RFH5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6RFH5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6RFH5
PhosPhoSitePlusQ6RFH5
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom_sf    WDR74/Nsa1   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR74
SuperfamilyQ6RFH5
AlphaFold pdb e-kbQ6RFH5   
Human Protein Atlas [tissue]ENSG00000133316-WDR74 [tissue]
HPRD08548
Protein Interaction databases
DIP (DOE-UCLA)Q6RFH5
IntAct (EBI)Q6RFH5
BioGRIDWDR74
STRING (EMBL)WDR74
ZODIACWDR74
Ontologies - Pathways
QuickGOQ6RFH5
Ontology : AmiGOblastocyst formation  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  nucleolus  nucleolus  nucleolus  rRNA processing  RNA metabolic process  preribosome, large subunit precursor  ribosomal large subunit biogenesis  ribosomal large subunit biogenesis  
Ontology : EGO-EBIblastocyst formation  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  nucleolus  nucleolus  nucleolus  rRNA processing  RNA metabolic process  preribosome, large subunit precursor  ribosomal large subunit biogenesis  ribosomal large subunit biogenesis  
NDEx NetworkWDR74
Atlas of Cancer Signalling NetworkWDR74
Wikipedia pathwaysWDR74
Orthology - Evolution
OrthoDB54663
GeneTree (enSembl)ENSG00000133316
Phylogenetic Trees/Animal Genes : TreeFamWDR74
Homologs : HomoloGeneWDR74
Homology/Alignments : Family Browser (UCSC)WDR74
Gene fusions - Rearrangements
Fusion : QuiverWDR74
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR74 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR74
dbVarWDR74
ClinVarWDR74
MonarchWDR74
1000_GenomesWDR74 
Exome Variant ServerWDR74
GNOMAD BrowserENSG00000133316
Varsome BrowserWDR74
ACMGWDR74 variants
VarityQ6RFH5
Genomic Variants (DGV)WDR74 [DGVbeta]
DECIPHERWDR74 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR74 
Mutations
ICGC Data PortalWDR74 
TCGA Data PortalWDR74 
Broad Tumor PortalWDR74
OASIS PortalWDR74 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR74  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWDR74
Mutations and Diseases : HGMDWDR74
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaWDR74
DgiDB (Drug Gene Interaction Database)WDR74
DoCM (Curated mutations)WDR74
CIViC (Clinical Interpretations of Variants in Cancer)WDR74
Cancer3DWDR74
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617947   
Orphanet
DisGeNETWDR74
MedgenWDR74
Genetic Testing Registry WDR74
NextProtQ6RFH5 [Medical]
GENETestsWDR74
Target ValidationWDR74
Huge Navigator WDR74 [HugePedia]
ClinGenWDR74
Clinical trials, drugs, therapy
MyCancerGenomeWDR74
Protein Interactions : CTDWDR74
Pharm GKB GenePA142670578
PharosQ6RFH5
Clinical trialWDR74
Miscellaneous
canSAR (ICR)WDR74
HarmonizomeWDR74
DataMed IndexWDR74
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXWDR74
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 16:28:29 CEST 2021

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