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WDR74 (WD repeat domain 74)

Identity

Alias_symbol (synonym)FLJ10439
Other alias-
HGNC (Hugo) WDR74
LocusID (NCBI) 54663
Atlas_Id 75729
Location 11q12.3  [Link to chromosome band 11q12]
Location_base_pair Starts at 62832905 and ends at 62839659 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGEF17 (11q13.4) / WDR74 (11q12.3)NXF1 (11q12.3) / WDR74 (11q12.3)STIP1 (11q13.1) / WDR74 (11q12.3)
STX5 (11q12.3) / WDR74 (11q12.3)WDR74 (11q12.3) / ANKS1B (12q23.1)WDR74 (11q12.3) / DHTKD1 (10p14)
WDR74 (11q12.3) / DOT1L (19p13.3)WDR74 (11q12.3) / GALC (14q31.3)WDR74 (11q12.3) / GLUL (1q25.3)
WDR74 (11q12.3) / GNAI3 (1p13.3)WDR74 (11q12.3) / GTF3C5 (9q34.2)WDR74 (11q12.3) / IMMP2L (7q31.1)
WDR74 (11q12.3) / INTS7 (1q32.3)WDR74 (11q12.3) / KNG1 (3q27.3)WDR74 (11q12.3) / LAMP2 (Xq24)
WDR74 (11q12.3) / LILRB3 (19q13.42)WDR74 (11q12.3) / PAQR6 (1q22)WDR74 (11q12.3) / PITRM1 (10p15.2)
WDR74 (11q12.3) / RALGDS (9q34.2)WDR74 (11q12.3) / RMND5A (2p11.2)WDR74 (11q12.3) / SART3 (12q23.3)
WDR74 (11q12.3) / SEPT8 (5q31.1)WDR74 (11q12.3) / SRGAP2 (1q32.1)WDR74 (11q12.3) / SUGP2 (19p13.11)
WDR74 (11q12.3) / TAPBPL (12p13.31)WDR74 (11q12.3) / TMCC2 (1q32.1)WDR74 (11q12.3) / TMEM25 (11q23.3)
WDR74 (11q12.3) / TRMT12 (8q24.13)WDR74 (11q12.3) / ZNF143 (11p15.4)ARHGEF17 WDR74
STX5 WDR74NXF1 WDR74

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)WDR74   25529
Cards
Entrez_Gene (NCBI)WDR74  54663  WD repeat domain 74
Aliases
GeneCards (Weizmann)WDR74
Ensembl hg19 (Hinxton)ENSG00000133316 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133316 [Gene_View]  chr11:62832905-62839659 [Contig_View]  WDR74 [Vega]
ICGC DataPortalENSG00000133316
TCGA cBioPortalWDR74
AceView (NCBI)WDR74
Genatlas (Paris)WDR74
WikiGenes54663
SOURCE (Princeton)WDR74
Genetics Home Reference (NIH)WDR74
Genomic and cartography
GoldenPath hg38 (UCSC)WDR74  -     chr11:62832905-62839659 -  11q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR74  -     11q12.3   [Description]    (hg19-Feb_2009)
EnsemblWDR74 - 11q12.3 [CytoView hg19]  WDR74 - 11q12.3 [CytoView hg38]
Mapping of homologs : NCBIWDR74 [Mapview hg19]  WDR74 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK001301 AK025383 AK292330 AK303186 AY500828
RefSeq transcript (Entrez)NM_001307977 NM_018093
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR74
Cluster EST : UnigeneHs.654620 [ NCBI ]
CGAP (NCI)Hs.654620
Alternative Splicing GalleryENSG00000133316
Gene ExpressionWDR74 [ NCBI-GEO ]   WDR74 [ EBI - ARRAY_EXPRESS ]   WDR74 [ SEEK ]   WDR74 [ MEM ]
Gene Expression Viewer (FireBrowse)WDR74 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54663
GTEX Portal (Tissue expression)WDR74
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6RFH5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6RFH5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6RFH5
Splice isoforms : SwissVarQ6RFH5
PhosPhoSitePlusQ6RFH5
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR74
DMDM Disease mutations54663
Blocks (Seattle)WDR74
SuperfamilyQ6RFH5
Human Protein AtlasENSG00000133316
Peptide AtlasQ6RFH5
HPRD08548
IPIIPI00018192   IPI00165237   IPI00940461   IPI00984341   IPI01009139   IPI01010061   IPI01009665   
Protein Interaction databases
DIP (DOE-UCLA)Q6RFH5
IntAct (EBI)Q6RFH5
FunCoupENSG00000133316
BioGRIDWDR74
STRING (EMBL)WDR74
ZODIACWDR74
Ontologies - Pathways
QuickGOQ6RFH5
Ontology : AmiGOmolecular_function  protein binding  nucleus  nucleolus  biological_process  preribosome, large subunit precursor  ribosomal large subunit biogenesis  
Ontology : EGO-EBImolecular_function  protein binding  nucleus  nucleolus  biological_process  preribosome, large subunit precursor  ribosomal large subunit biogenesis  
NDEx NetworkWDR74
Atlas of Cancer Signalling NetworkWDR74
Wikipedia pathwaysWDR74
Orthology - Evolution
OrthoDB54663
GeneTree (enSembl)ENSG00000133316
Phylogenetic Trees/Animal Genes : TreeFamWDR74
HOVERGENQ6RFH5
HOGENOMQ6RFH5
Homologs : HomoloGeneWDR74
Homology/Alignments : Family Browser (UCSC)WDR74
Gene fusions - Rearrangements
Fusion: TCGAARHGEF17 WDR74
Fusion: TCGASTX5 WDR74
Fusion: TCGANXF1 WDR74
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR74 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR74
dbVarWDR74
ClinVarWDR74
1000_GenomesWDR74 
Exome Variant ServerWDR74
ExAC (Exome Aggregation Consortium)WDR74 (select the gene name)
Genetic variants : HAPMAP54663
Genomic Variants (DGV)WDR74 [DGVbeta]
DECIPHERWDR74 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR74 
Mutations
ICGC Data PortalWDR74 
TCGA Data PortalWDR74 
Broad Tumor PortalWDR74
OASIS PortalWDR74 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR74  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDWDR74
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WDR74
DgiDB (Drug Gene Interaction Database)WDR74
DoCM (Curated mutations)WDR74 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR74 (select a term)
intoGenWDR74
Cancer3DWDR74(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenWDR74
Genetic Testing Registry WDR74
NextProtQ6RFH5 [Medical]
TSGene54663
GENETestsWDR74
Target ValidationWDR74
Huge Navigator WDR74 [HugePedia]
snp3D : Map Gene to Disease54663
BioCentury BCIQWDR74
ClinGenWDR74
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54663
Chemical/Pharm GKB GenePA142670578
Clinical trialWDR74
Miscellaneous
canSAR (ICR)WDR74 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR74
EVEXWDR74
GoPubMedWDR74
iHOPWDR74
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 31 15:48:59 CEST 2017

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