WDR76 (WD repeat domain 76)

2007-02-01  

Identity

HGNC
WDR76
LOCATION
15q15.3
LOCUSID
79968
ALIAS
CDW14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79968
HGNC: 25773
Ensembl: ENSG00000092470

Variants:

dbSNP: 79968
ClinVar: 79968
TCGA: ENSG00000092470
COSMIC: WDR76

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092470ENST00000263795Q9H967
ENSG00000092470ENST00000381246A0A0C4DFX7
ENSG00000092470ENST00000452115C9JE56

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
272484962016WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.9
306556112019WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation.5
313627612019WDR76 degrades RAS and suppresses cancer stem cell activation in colorectal cancer.2
128602912003Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer.1

Citation

Dessen P

WDR76 (WD repeat domain 76)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45581/wdr76